Sexcord/ stromal ovarian tumors history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

The majority of patients with [disease name] are asymptomatic.

OR

The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History and Symptoms

  • Patients with ovarian sex cord-stromal tumors present in a much similar way as epithelial ovarian neoplasms, although a few sub-types do vary in their presentation[1][2][3][4][5][6][7]
  • Broadly we can categorize them as acute and subacute presentations

Subacute presentations

  • Adnexal mass:
    • This is the most common presentation of ovarian cancer
    • It may be discovered due to symptoms of pelvic pain or pressure, or sometimes may be found on a routine pelvic examination or an imaging study performed for detecting another medical condition
  • Abdominal & pelvic symptoms:
    • Bloating
    • Urinary urgency or frequency
    • Dysphagia(difficulty eating) or feeling full quickly
    • Pelvic or abdominal pain
  • Other less common symptoms include palpable lymphadenopathy and postmenopausal bleeding

Acute presentations

They can manifest themselves as bowel obstruction, pleural effusion and even venous thromboembolism

  • Pleural effusions:
    • They usually present with shortness of breath
    • We should proceed with a chest x-ray, followed by thoracentesis which reveals a malignant pleural effusion
  • Bowel obstruction:
    • Patients usually present with typical features of bowel obstruction like nausea, vomiting, abdominal pain and distention

History

Patients with [disease name]] may have a positive history of:

  • [History finding 1]
  • [History finding
  • [History finding 3]

Common Symptoms

Common symptoms of [disease] include:

  • [Symptom 1]
  • [Symptom 2]
  • [Symptom 3]

Less Common Symptoms

Less common symptoms of [disease name] include

  • [Symptom 1]
  • [Symptom 2]
  • [Symptom 3]

References

  1. Zheng G, Yu H, Kanerva A, Försti A, Sundquist K, Hemminki K (2018). "Familial risks of ovarian cancer by age at diagnosis, proband type and histology". PLoS ONE. 13 (10): e0205000. doi:10.1371/journal.pone.0205000. PMC 6169923. PMID 30281663.
  2. Olson SH, Mignone L, Nakraseive C, Caputo TA, Barakat RR, Harlap S (August 2001). "Symptoms of ovarian cancer". Obstet Gynecol. 98 (2): 212–7. PMID 11506835.
  3. Vine MF, Ness RB, Calingaert B, Schildkraut JM, Berchuck A (December 2001). "Types and duration of symptoms prior to diagnosis of invasive or borderline ovarian tumor". Gynecol. Oncol. 83 (3): 466–71. doi:10.1006/gyno.2001.6411. PMID 11733956.
  4. Yawn BP, Barrette BA, Wollan PC (October 2004). "Ovarian cancer: the neglected diagnosis". Mayo Clin. Proc. 79 (10): 1277–82. doi:10.4065/79.10.1277. PMID 15473410.
  5. Goff BA, Mandel LS, Melancon CH, Muntz HG (June 2004). "Frequency of symptoms of ovarian cancer in women presenting to primary care clinics". JAMA. 291 (22): 2705–12. doi:10.1001/jama.291.22.2705. PMID 15187051.
  6. Goff BA, Mandel LS, Drescher CW, Urban N, Gough S, Schurman KM, Patras J, Mahony BS, Andersen MR (January 2007). "Development of an ovarian cancer symptom index: possibilities for earlier detection". Cancer. 109 (2): 221–7. doi:10.1002/cncr.22371. PMID 17154394.
  7. Goff B (March 2012). "Symptoms associated with ovarian cancer". Clin Obstet Gynecol. 55 (1): 36–42. doi:10.1097/GRF.0b013e3182480523. PMID 22343227.

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