Sexcord/ stromal ovarian tumors epidemiology and demographics: Difference between revisions
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{{Sexcord/ stromal ovarian tumors}} | {{Sexcord/ stromal ovarian tumors}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} ; {{M.N}} | ||
==Overview== | ==Overview== | ||
The [[Year|yearly]] adjusted [[incidence rate]] is approximately 2 per 1,000,000 [[women]] for sexcord-stromal ovarian tumors(SCSTs). The [[mortality rate]] has gradually been declining from1976 (10.0 per 100,000) and 2015 (6.7 per 100,000) by 33%. The [[age]] at presentation varies depending on the subtypes of sexcord-stromal ovarian tumors. Sexcord-stromal ovarian tumors(SCSTs) have more predilection in [[women]] of Caucasian background. Rates are highest among Whites, intermediate for Hispanics, and lowest among Blacks, and Asian people. Intrestingly there has been increases in [[incidence]] and [[Mortality rate|mortality rates]] in less [[Developed country|developed countries]] with recent economic growth and [[lifestyle]] changes. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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===Case-fatality rate/Mortality rate=== | ===Case-fatality rate/Mortality rate=== | ||
*The [[mortality rate]] has gradually been declining from1976 (10.0 per 100,000) and 2015 (6.7 per 100,000) by 33%<ref name="pmid29809280">{{cite journal |vauthors=Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL |title=Ovarian cancer statistics, 2018 |journal=CA Cancer J Clin |volume=68 |issue=4 |pages=284–296 |date=July 2018 |pmid=29809280 |doi=10.3322/caac.21456 |url=}}</ref><ref name="pmid26086565">{{cite journal |vauthors=Sopik V, Rosen B, Giannakeas V, Narod SA |title=Why have ovarian cancer mortality rates declined? Part III. Prospects for the future |journal=Gynecol. Oncol. |volume=138 |issue=3 |pages=757–61 |date=September 2015 |pmid=26086565 |doi=10.1016/j.ygyno.2015.06.019 |url=}}</ref><ref name="pmid26080287">{{cite journal |vauthors=Sopik V, Iqbal J, Rosen B, Narod SA |title=Why have ovarian cancer mortality rates declined? Part I. Incidence |journal=Gynecol. Oncol. |volume=138 |issue=3 |pages=741–9 |date=September 2015 |pmid=26080287 |doi=10.1016/j.ygyno.2015.06.017 |url=}}</ref><ref name="pmid26080288">{{cite journal |vauthors=Sopik V, Iqbal J, Rosen B, Narod SA |title=Why have ovarian cancer mortality rates declined? Part II. Case-fatality |journal=Gynecol. Oncol. |volume=138 |issue=3 |pages=750–6 |date=September 2015 |pmid=26080288 |doi=10.1016/j.ygyno.2015.06.016 |url=}}</ref> | *The [[mortality rate]] has gradually been declining from1976 (10.0 per 100,000) and 2015 (6.7 per 100,000) by 33%<ref name="pmid29809280">{{cite journal |vauthors=Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL |title=Ovarian cancer statistics, 2018 |journal=CA Cancer J Clin |volume=68 |issue=4 |pages=284–296 |date=July 2018 |pmid=29809280 |doi=10.3322/caac.21456 |url=}}</ref><ref name="pmid26086565">{{cite journal |vauthors=Sopik V, Rosen B, Giannakeas V, Narod SA |title=Why have ovarian cancer mortality rates declined? Part III. Prospects for the future |journal=Gynecol. Oncol. |volume=138 |issue=3 |pages=757–61 |date=September 2015 |pmid=26086565 |doi=10.1016/j.ygyno.2015.06.019 |url=}}</ref><ref name="pmid26080287">{{cite journal |vauthors=Sopik V, Iqbal J, Rosen B, Narod SA |title=Why have ovarian cancer mortality rates declined? Part I. Incidence |journal=Gynecol. Oncol. |volume=138 |issue=3 |pages=741–9 |date=September 2015 |pmid=26080287 |doi=10.1016/j.ygyno.2015.06.017 |url=}}</ref><ref name="pmid26080288">{{cite journal |vauthors=Sopik V, Iqbal J, Rosen B, Narod SA |title=Why have ovarian cancer mortality rates declined? Part II. Case-fatality |journal=Gynecol. Oncol. |volume=138 |issue=3 |pages=750–6 |date=September 2015 |pmid=26080288 |doi=10.1016/j.ygyno.2015.06.016 |url=}}</ref> | ||
*Improvements in either early detection or in [[Treatment groups|treatment]] did not contribute to the decline in [[mortality]] because there was no reduction in [[ovarian cancer]] [[Case-fatality rate|case-fatality]] at 12 years | *Improvements in either early [[Detection and Diagnosis in Adulthood|detection]] or in [[Treatment groups|treatment]] did not contribute to the decline in [[mortality]] because there was no reduction in [[ovarian cancer]] [[Case-fatality rate|case-fatality]] at 12 years | ||
*A decline in the [[incidence rate]] of [[ovarian cancer]] parallels the decline in mortality which in turn may be due to a decreased proportion of ovarian cancer patients who die from their cancer (case-fatality) | *A decline in the [[incidence rate]] of [[ovarian cancer]] parallels the decline in [[mortality]] which in turn may be due to a decreased [[Proportionality (mathematics)|proportion]] of [[ovarian cancer]] [[patients]] who [[Died|die]] from their [[cancer]] ([[Case fatality|case-fatality]]) | ||
===Age=== | ===Age=== | ||
The age at presentation varies depending on the subtypes of sexcord-stromal ovarian tumors:<ref name="pmid26054417">{{cite journal |vauthors=Horta M, Cunha TM |title=Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists |journal=Diagn Interv Radiol |volume=21 |issue=4 |pages=277–86 |date=2015 |pmid=26054417 |pmc=4498422 |doi=10.5152/dir.2015.34414 |url=}}</ref> | The [[age]] at presentation varies depending on the subtypes of sexcord-stromal ovarian tumors:<ref name="pmid26054417">{{cite journal |vauthors=Horta M, Cunha TM |title=Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists |journal=Diagn Interv Radiol |volume=21 |issue=4 |pages=277–86 |date=2015 |pmid=26054417 |pmc=4498422 |doi=10.5152/dir.2015.34414 |url=}}</ref> | ||
'''Fibromas''': | '''[[Fibroma|Fibromas]]''': | ||
*Although they can present at any age, the mean age of occurrence is in the late forties | *Although they can present at any [[age]], the [[mean]] [[age]] of occurrence is in the late forties | ||
'''Thecomas''': | '''[[Thecoma|Thecomas]]''': | ||
*They are more likely to occur in postmenopausal women | *They are more likely to occur in [[postmenopausal]] [[women]] | ||
'''Sclerosing stromal tumor'''(SSTs): | '''Sclerosing stromal tumor'''(SSTs): | ||
*SSTs are more likely to occur in young women | *SSTs are more likely to occur in [[Young adult|young]] [[women]] | ||
*Approximately 80% of the reported cases are under 30 years of age | *Approximately 80% of the reported cases are under 30 years of [[age]] | ||
*A few cases have been reported in premenarchal girls, although SSTs most commonly occur after menarche | *A few cases have been reported in premenarchal girls, although SSTs most commonly occur after [[menarche]] | ||
'''Steroid cell tumors''': | '''Steroid cell tumors''': | ||
*The average age of presentation is 43 years | *The average [[age]] of presentation is 43 [[Year|years]] | ||
'''Adult and juvenile granulosa cell tumors''': | '''[[Granulosa cell tumors|Adult and juvenile granulosa cell tumors]]''': | ||
*The incidence of adult granulosa cell tumors peaks in early postmenopausal women | *The [[incidence]] of [[Granulosa cell tumors|adult granulosa cell tumors]] peaks in early [[postmenopausal]] [[women]] | ||
*The juvenile form occurs predominantly in children and young women (<30 years) | *The juvenile form occurs predominantly in [[children]] and young [[women]] (<30 years) | ||
===Race=== | ===Race=== | ||
*Racial predilection do exist for sexcord-stromal ovarian tumors<ref name="pmid27798862">{{cite journal |vauthors=Boussios S, Zarkavelis G, Seraj E, Zerdes I, Tatsi K, Pentheroudakis G |title=Non-epithelial Ovarian Cancer: Elucidating Uncommon Gynaecological Malignancies |journal=Anticancer Res. |volume=36 |issue=10 |pages=5031–5042 |date=October 2016 |pmid=27798862 |doi=10.21873/anticanres.11072 |url=}}</ref><ref name="pmid6364995">{{cite journal |vauthors=Anteby SO, Mor Yosef S, Schenker JG |title=Ovarian cancer. Geographical, host and environmental factors. An overview |journal=Arch. Gynecol. |volume=234 |issue=2 |pages=137–48 |date=1983 |pmid=6364995 |doi= |url=}}</ref> | *[[Racial]] predilection do exist for sexcord-stromal ovarian tumors<ref name="pmid27798862">{{cite journal |vauthors=Boussios S, Zarkavelis G, Seraj E, Zerdes I, Tatsi K, Pentheroudakis G |title=Non-epithelial Ovarian Cancer: Elucidating Uncommon Gynaecological Malignancies |journal=Anticancer Res. |volume=36 |issue=10 |pages=5031–5042 |date=October 2016 |pmid=27798862 |doi=10.21873/anticanres.11072 |url=}}</ref><ref name="pmid6364995">{{cite journal |vauthors=Anteby SO, Mor Yosef S, Schenker JG |title=Ovarian cancer. Geographical, host and environmental factors. An overview |journal=Arch. Gynecol. |volume=234 |issue=2 |pages=137–48 |date=1983 |pmid=6364995 |doi= |url=}}</ref> | ||
*Racial differences in incidence and mortality within the United States are similar to the observed international variation | *[[Racial]] differences in [[incidence]] and [[mortality]] within the [[United States]] are similar to the observed international variation | ||
*Sexcord-stromal ovarian tumors(SCSTs) have more predilection in women of Caucasian background | *Sexcord-stromal ovarian tumors(SCSTs) have more predilection in [[women]] of Caucasian background | ||
*Rates are highest among Whites, intermediate for Hispanics, and lowest among Blacks, and Asian people | *Rates are highest among Whites, intermediate for Hispanics, and lowest among Blacks, and Asian people | ||
[[File:USCIS.gif|none]] | [[File:USCIS.gif|none]] | ||
===Developed Countries versus Developing countries=== | ===Developed Countries versus Developing countries=== | ||
*The incidence and mortality has gradually declined since the 1990s in most developed countries, largely including North America and Europe | *The [[incidence]] and [[mortality]] has gradually declined since the 1990s in most [[Developed country|developed countries,]] largely including North America and Europe | ||
*Intrestingly there has been increases in incidence and mortality rates in less developed countries with recent economic growth and lifestyle changes | *Intrestingly there has been increases in [[incidence]] and [[Mortality rate|mortality rates]] in less [[Developed country|developed countries]] with recent economic growth and [[lifestyle]] changes | ||
*In China, this increase is obvious only among rural women rather than those in more developed urban areas | *In China, this increase is obvious only among [[Rurals|rural]] [[women]] rather than those in more [[Developed country|developed]] [[Urban area|urban areas]] | ||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category: | [[Category:Disease]] | ||
[[Category:Types of cancer]] | |||
[[Category:Gynecology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gynecology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 18:42, 5 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Maneesha Nandimandalam, M.B.B.S.[2]
Overview
The yearly adjusted incidence rate is approximately 2 per 1,000,000 women for sexcord-stromal ovarian tumors(SCSTs). The mortality rate has gradually been declining from1976 (10.0 per 100,000) and 2015 (6.7 per 100,000) by 33%. The age at presentation varies depending on the subtypes of sexcord-stromal ovarian tumors. Sexcord-stromal ovarian tumors(SCSTs) have more predilection in women of Caucasian background. Rates are highest among Whites, intermediate for Hispanics, and lowest among Blacks, and Asian people. Intrestingly there has been increases in incidence and mortality rates in less developed countries with recent economic growth and lifestyle changes.
Epidemiology and Demographics
Incidence
- Ovarian sex cord-stromal tumors are very uncommon neoplasms that represent only 7% of all ovarian tumors[1][2][3][4]
- The yearly adjusted incidence rate is approximately 2 per 1,000,000 women for sexcord-stromal ovarian tumors(SCSTs)
- Overall ovarian cancer incidence shows declining trends from 1985 (16.6 per 100,000) to 2014 (11.8 per 100,000) by 29%
Case-fatality rate/Mortality rate
- The mortality rate has gradually been declining from1976 (10.0 per 100,000) and 2015 (6.7 per 100,000) by 33%[3][5][6][7]
- Improvements in either early detection or in treatment did not contribute to the decline in mortality because there was no reduction in ovarian cancer case-fatality at 12 years
- A decline in the incidence rate of ovarian cancer parallels the decline in mortality which in turn may be due to a decreased proportion of ovarian cancer patients who die from their cancer (case-fatality)
Age
The age at presentation varies depending on the subtypes of sexcord-stromal ovarian tumors:[8]
- They are more likely to occur in postmenopausal women
Sclerosing stromal tumor(SSTs):
- SSTs are more likely to occur in young women
- Approximately 80% of the reported cases are under 30 years of age
- A few cases have been reported in premenarchal girls, although SSTs most commonly occur after menarche
Steroid cell tumors:
Adult and juvenile granulosa cell tumors:
- The incidence of adult granulosa cell tumors peaks in early postmenopausal women
- The juvenile form occurs predominantly in children and young women (<30 years)
Race
- Racial predilection do exist for sexcord-stromal ovarian tumors[2][9]
- Racial differences in incidence and mortality within the United States are similar to the observed international variation
- Sexcord-stromal ovarian tumors(SCSTs) have more predilection in women of Caucasian background
- Rates are highest among Whites, intermediate for Hispanics, and lowest among Blacks, and Asian people
Developed Countries versus Developing countries
- The incidence and mortality has gradually declined since the 1990s in most developed countries, largely including North America and Europe
- Intrestingly there has been increases in incidence and mortality rates in less developed countries with recent economic growth and lifestyle changes
- In China, this increase is obvious only among rural women rather than those in more developed urban areas
References
- ↑ Reid BM, Permuth JB, Sellers TA (February 2017). "Epidemiology of ovarian cancer: a review". Cancer Biol Med. 14 (1): 9–32. doi:10.20892/j.issn.2095-3941.2016.0084. PMC 5365187. PMID 28443200.
- ↑ 2.0 2.1 Boussios S, Zarkavelis G, Seraj E, Zerdes I, Tatsi K, Pentheroudakis G (October 2016). "Non-epithelial Ovarian Cancer: Elucidating Uncommon Gynaecological Malignancies". Anticancer Res. 36 (10): 5031–5042. doi:10.21873/anticanres.11072. PMID 27798862.
- ↑ 3.0 3.1 Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL (July 2018). "Ovarian cancer statistics, 2018". CA Cancer J Clin. 68 (4): 284–296. doi:10.3322/caac.21456. PMID 29809280.
- ↑ Lowe KA, Chia VM, Taylor A, O'Malley C, Kelsh M, Mohamed M, Mowat FS, Goff B (July 2013). "An international assessment of ovarian cancer incidence and mortality". Gynecol. Oncol. 130 (1): 107–14. doi:10.1016/j.ygyno.2013.03.026. PMID 23558050.
- ↑ Sopik V, Rosen B, Giannakeas V, Narod SA (September 2015). "Why have ovarian cancer mortality rates declined? Part III. Prospects for the future". Gynecol. Oncol. 138 (3): 757–61. doi:10.1016/j.ygyno.2015.06.019. PMID 26086565.
- ↑ Sopik V, Iqbal J, Rosen B, Narod SA (September 2015). "Why have ovarian cancer mortality rates declined? Part I. Incidence". Gynecol. Oncol. 138 (3): 741–9. doi:10.1016/j.ygyno.2015.06.017. PMID 26080287.
- ↑ Sopik V, Iqbal J, Rosen B, Narod SA (September 2015). "Why have ovarian cancer mortality rates declined? Part II. Case-fatality". Gynecol. Oncol. 138 (3): 750–6. doi:10.1016/j.ygyno.2015.06.016. PMID 26080288.
- ↑ Horta M, Cunha TM (2015). "Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists". Diagn Interv Radiol. 21 (4): 277–86. doi:10.5152/dir.2015.34414. PMC 4498422. PMID 26054417.
- ↑ Anteby SO, Mor Yosef S, Schenker JG (1983). "Ovarian cancer. Geographical, host and environmental factors. An overview". Arch. Gynecol. 234 (2): 137–48. PMID 6364995.