Sandbox chemo1

Chemotherapeutic Agents by Category

Cytotoxic Chemotherapy

Alkylating agents

Nitrogen mustards

• Chlorambucil (Leukeran)

• Cyclophosphamide (Cytoxan)

• Ifosfamide (Iflex)

• Melphalan (Alkeran)

• Mechlorethamine (Mustargen)

Ethylenimines

• Thiotepa (Tepadina)

Methylhydrazine derivative

• Procarbazine (Matulane)

Alkyl sulfonate

• Busulfan (Myleran)

Nitrosoureas

• Bendamustine (Treanda)

• Carmustine (BiCNU)
• Lomustine (CeeNU)

• Streptozocin (Zanosar)

Triazenes

• Altretamine (Hexalen)
• Dacarbazine (Dtic-Dome)
• Temozolomide (Temodar)

Platinum coordination complexes

• Carboplatin (Paraplatin)
• Cisplatin (Platinol)
• Oxaliplatin (Eloxatin)

---

Anthracyclines

• Daunorubicin (Daunoxome)
• Doxorubicin (Adriamycin,Rubex)
• Epirubicin (Ellence)
• Idarubicin (Idamycin)

Antimetabolites

• Capecitabine (Xeloda)
• Fluorouracil (Adrucil, Efudex)
• Floxuridine (FUDR)
• Fludarabine (Fludara)
• Gemcitabine (Gemzar)
• Hydroxyurea (Hydrea)
• Mercaptopurine (Purinethol)
• Methotrexate (Mexate,Folex)

Antimitotic agent

• Docetaxel (Taxotere)
• Eribulin (Halaven)
• Etoposide (Vespid)
• Ixabepilone (Ixempra)
• Vinblastine (Velban,Velsar)
• Vincristine (Oncovin,Vincasar)
• Vinorelbine (Navelbine)

DNA synthesis inhibitors

• Streptozocin (Zanosar)

Microtubule inhibitors

• Ixabepilone (Ixempra)

Nitrogen mustards

• Estramustine (Emcyt)
• Mechlorethamine (Mustargen)

Nitrosureas

• Lomustine (CeeNU)

Proteasome inhibitors

• Carfilzomib (Kyprolis)

Topoisomerase inhibitors

• Irinotecan (Camptosar)

Vinca alkaloids

• Vinblastine (Velban,Velsar)
• Vincristine (Oncovin,Vincasar)

---

Endocrine therapy

Antiandrogens

• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Dutasteride (Avodart)
• Enzalutamide (Xtandi)
• Finasteride (Proscar)
• Flutamide (Eulexin)
• Ketoconazole (Nizoral)
• Leuprolide (Lupron)
• Nilutamide (Nilandron)
• Triptorelin (Trelstar)

Steroid synthesis inhibitors

• Abiraterone (Zytiga)
• Aminoglutethimide (Cytadren)
• Anastrozole (Arimidex)
• Exemestane (Aromasin)
• Letrozole (Femara)
• Mitotane (Lysodren)

Androgen receptor inhibitors

• Nilutamide (Nilandron)

GnRH agonists

• Buserelin (Superfact)
• Goserelin Acetate (Zoladex)
• Leuprolide (Lupron)

GnRH antagonists

• Degarelix (Firmagon)

Aromatase inhibitors

• Anastrozole (Arimidex)
• Exemestane (Aromasin))
• Letrozole (Femara)

Selective estrogen receptor modulators

---

Biologics

Antibody medications

• Cetuximab (Erbitux)
• Denosumab (Xgeva)
• Ibritumomab tiuxetan (Zevalin)
• Ipilimumab (Yervoy)
• Nivolumab (Opdivo)
• Obinutuzumab (Gazyva)
• Ofatumumab (Arzerra)
• Pembrolizumab (KEYTRUDA)

Antibody-drug conjugates

• Ado-trastuzumab emtansine (Kadcyla)
• Brentuximab vedotin (Adcetris)
• Gemtuzumab ozogamicin (Mylotarg)

Anti-HER2 medications

• Ado-trastuzumab emtansine (Kadcyla)
• Trastuzumab (Herceptin)

Enzymes

• Pegaspargase (Oncaspar)
• Glucarpidase (Voraxaze)

IL-6 inhibitors

• Siltuximab (Sylvant)

IL-2 inhibitors

• Denileukin diftitox (Ontak)

Immunotherapy

• Interferon alfa-2b (Intron A)

Immunomodulatory drugs (IMiDs)

• Everolimus (Afinitor)
• Lenalidomide (Revlimid)
• Pomalidomide (Pomalyst)

---

Hematopoietic Growth Factors

Erythrocyte growth factors

• Erythropoietin (Procrit)

Granulocyte growth factors

• Filgrastim (Granix)
• Sargramostin (Leukine)
• Tbo-filgrastim (Granix)

Megakaryocyte growth factors

• Eltrombopag (Promacta)
• Romiplostim (Nplate)

---

Supportive Medications

Chemotherapy protective agents

• Amifostine (Ethyol)
• Cyanocobalamin
• Dexrazoxane (Zinecard)
• Folinic acid (Leucovorin)
• Glucarpidase (Voraxaze)
• Levoleucovorin (Fusilev)
• Mesna (Mesnex)

Antiemetic agents

• Netupitant and palonosetron (Akynzeo)

RANK ligand inhibitors

• Denosumab (Xgeva)

---

Miscellaneous

Antibiotic

• Mitomycin C (Mutamycin)

Bisphosphonate

• Zoledronic Acid (Zometa)

Endocrine-Metabolic agents

• Fluoxymesterone (Halotestin)
• Medroxyprogesterone acetate (Provera)
• Megestrol (Megace)

HDAC inhibitors

• Belinostat (Beleodaq)
• Romidepsin (Istodax)
• Vorinostat (Zolinza)

Hedgehog pathway inhibitors

• Vismodegib (Erivedge)

Kinase inhibitors

• Afatinib (Gliotrif)
• Cabozantinib (Cometriq)
• Crizotinib (Xalkori)
• Dasatinib (Sprycel)
• Erlotinib (Tarceva)
• Ibrutinib (Imbruvica)
• Idelalisib (Zydelig)
• Lapatinib (Tykerb)
• Nilotinib (Tasigna)
• Palbociclib (Ibrance)

Radioactive agents

• Radium-223 chloride (Xofigo)

Somatostatin analogues

• Octreotide (Octreotide)

VEGF receptor-2 antagonists

• Ramucirumab (Cyramza)

---