SPI1

Spleen focus forming virus (SFFV) proviral integration oncogene spi1
File:PBB Protein SPI1 image.jpg PDB rendering based on 1pue.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1pue​
Identifiers
Symbols	SPI1 ; OF; PU.1; SFPI1; SPI-1; SPI-A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2346
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SPI1 205312 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Spleen focus forming virus (SFFV) proviral integration oncogene spi1, also known as SPI1, is a human gene.

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Ray D, Culine S, Tavitain A, Moreau-Gachelin F (1990). "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663–8. PMID 1693183.CS1 maint: Multiple names: authors list (link)
• Klemsz MJ, McKercher SR, Celada A; et al. (1990). "The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene". Cell. 61 (1): 113–24. PMID 2180582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen VC, Ray D, Gross MS; et al. (1990). "Localization of the human oncogene SPI1 on chromosome 11, region p11.22". Hum. Genet. 84 (6): 542–6. PMID 2338340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Ray-Gallet D, Zhang P; et al. (1995). "PU.1 (Spi-1) autoregulates its expression in myeloid cells". Oncogene. 11 (8): 1549–60. PMID 7478579.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". J. Immunol. 155 (9): 4330–8. PMID 7594592.CS1 maint: Multiple names: authors list (link)
• Pongubala JM, Atchison ML (1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer". J. Biol. Chem. 270 (17): 10304–13. PMID 7730336.
• Hromas R, Orazi A, Neiman RS; et al. (1993). "Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1". Blood. 82 (10): 2998–3004. PMID 8219191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hagemeier C, Bannister AJ, Cook A, Kouzarides T (1993). "The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1580–4. PMID 8434021.CS1 maint: Multiple names: authors list (link)
• Hallier M, Tavitian A, Moreau-Gachelin F (1996). "The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb". J. Biol. Chem. 271 (19): 11177–81. PMID 8626664.CS1 maint: Multiple names: authors list (link)
• Bassuk AG, Anandappa RT, Leiden JM (1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". J. Virol. 71 (5): 3563–73. PMID 9094628.CS1 maint: Multiple names: authors list (link)
• Li SL, Valente AJ, Zhao SJ, Clark RA (1997). "PU.1 is essential for p47(phox) promoter activity in myeloid cells". J. Biol. Chem. 272 (28): 17802–9. PMID 9211934.CS1 maint: Multiple names: authors list (link)
• Tsukada J, Misago M, Serino Y; et al. (1997). "Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1". Blood. 90 (8): 3142–53. PMID 9376596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hallier M, Lerga A, Barnache S; et al. (1998). "The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS". J. Biol. Chem. 273 (9): 4838–42. PMID 9478924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki S, Kumatori A, Haagen IA; et al. (1998). "PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6085–90. PMID 9600921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carrère S, Verger A, Flourens A; et al. (1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains". Oncogene. 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato M, Morii E, Takebayashi-Suzuki K; et al. (1999). "Microphthalmia-associated transcription factor interacts with PU.1 and c-Fos: determination of their subcellular localization". Biochem. Biophys. Res. Commun. 254 (2): 384–7. doi:10.1006/bbrc.1998.9918. PMID 9918847.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMID 10022840.CS1 maint: Multiple names: authors list (link)
• Yamamoto H, Kihara-Negishi F, Yamada T; et al. (1999). "Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP". Oncogene. 18 (7): 1495–501. doi:10.1038/sj.onc.1202427. PMID 10050886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". J. Biol. Chem. 274 (16): 11115–24. PMID 10196196.CS1 maint: Multiple names: authors list (link)
• Mao S, Frank RC, Zhang J; et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–44. PMID 10207087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)