SOX5: Difference between revisions

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Latest revision as of 06:51, 11 September 2017

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.^[1]^[2]

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[2]

References

↑ Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Sep 1996). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics. 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465.
↑ ^2.0 ^2.1 "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5".

Kamachi Y, Uchikawa M, Kondoh H (Apr 2000). "Pairing SOX off: with partners in the regulation of embryonic development". Trends in Genetics. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.
Bowles J, Schepers G, Koopman P (Nov 2000). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Developmental Biology. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.
Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (Jun 1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.
Connor F, Cary PD, Read CM, Preston NS, Driscoll PC, Denny P, Crane-Robinson C, Ashworth A (Aug 1994). "DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5". Nucleic Acids Research. 22 (16): 3339–46. doi:10.1093/nar/22.16.3339. PMC 523727. PMID 8078769.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lefebvre V, Li P, de Crombrugghe B (Oct 1998). "A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene". The EMBO Journal. 17 (19): 5718–33. doi:10.1093/emboj/17.19.5718. PMC 1170900. PMID 9755172.
Uusitalo H, Hiltunen A, Ahonen M, Gao TJ, Lefebvre V, Harley V, Kähäri VM, Vuorio E (Oct 2001). "Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing". Journal of Bone and Mineral Research. 16 (10): 1837–45. doi:10.1359/jbmr.2001.16.10.1837. PMID 11585348.
Zafarana G, Gillis AJ, van Gurp RJ, Olsson PG, Elstrodt F, Stoop H, Millán JL, Oosterhuis JW, Looijenga LH (Mar 2002). "Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation". Cancer Research. 62 (6): 1822–31. PMID 11912161.
Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S (Sep 2002). "Identification and characterization of the human long form of Sox5 (L-SOX5) gene". Gene. 298 (1): 59–68. doi:10.1016/S0378-1119(02)00927-7. PMID 12406576.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[pmid8812465-1] Wunderle VM, Critcher R, Ashworth A, Goodfellow PN (Sep 1996). "Cloning and characterization of SOX5, a new member of the human SOX gene family". Genomics. 36 (2): 354–8. doi:10.1006/geno.1996.0474. PMID 8812465.

[entrez-2] 2.0 ^2.1 "Entrez Gene: SOX5 SRY (sex determining region Y)-box 5".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Transcription factor SOX-5''' is a [[protein]] that in humans is encoded by the ''SOX5'' [[gene]].<ref name="pmid8812465">{{cite journal | vauthors = Wunderle VM, Critcher R, Ashworth A, Goodfellow PN | title = Cloning and characterization of SOX5, a new member of the human SOX gene family | journal = Genomics | volume = 36 | issue = 2 | pages = 354–8 | date = Sep 1996 | pmid = 8812465 | pmc =  | doi = 10.1006/geno.1996.0474 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SOX5 SRY (sex determining region Y)-box 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6660| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_SOX5_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i11.
- | PDB = {{PDB2|1i11}}
- | Name = SRY (sex determining region Y)-box 5
- | HGNCid = 11201
- | Symbol = SOX5
- | AltSymbols =; L-SOX5; MGC35153
- | OMIM = 604975
- | ECnumber =
- | Homologene = 21378
- | MGIid = 98367
- | GeneAtlas_image1 = PBB_GE_SOX5_207336_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}} {{GNF_GO|id=GO:0051216 |text = cartilage development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6660
-    | Hs_Ensembl = ENSG00000134532
-    | Hs_RefseqProtein = NP_008871
-    | Hs_RefseqmRNA = NM_006940
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 23576499
-    | Hs_GenLoc_end = 23993904
-    | Hs_Uniprot = P35711
-    | Mm_EntrezGene = 20678
-    | Mm_Ensembl = ENSMUSG00000041540
-    | Mm_RefseqmRNA = NM_011444
-    | Mm_RefseqProtein = NP_035574
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 143790486
-    | Mm_GenLoc_end = 144161586
-    | Mm_Uniprot = Q3TVF9
-  }}
-}}
-'''SRY (sex determining region Y)-box 5''', also known as '''SOX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOX5 SRY (sex determining region Y)-box 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6660| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
-| summary_text = This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SOX5 SRY (sex determining region Y)-box 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6660| accessdate = }}</ref>
-}}
-==See also==
+== See also ==
 * [[SOX genes]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Kondoh H | title = Pairing SOX off: with partners in the regulation of embryonic development | journal = Trends in Genetics | volume = 16 | issue = 4 | pages = 182–7 | date = Apr 2000 | pmid = 10729834 | doi = 10.1016/S0168-9525(99)01955-1 }}
-| citations =
+* {{cite journal | vauthors = Bowles J, Schepers G, Koopman P | title = Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators | journal = Developmental Biology | volume = 227 | issue = 2 | pages = 239–55 | date = Nov 2000 | pmid = 11071752 | doi = 10.1006/dbio.2000.9883 }}
-*{{cite journal  | author=Kamachi Y, Uchikawa M, Kondoh H |title=Pairing SOX off: with partners in the regulation of embryonic development. |journal=Trends Genet. |volume=16 |issue= 4 |pages= 182-7 |year= 2000 |pmid= 10729834 |doi=  }}
+* {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Current Opinion in Genetics & Development | volume = 12 | issue = 4 | pages = 441–6 | date = Aug 2002 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }}
-*{{cite journal  | author=Bowles J, Schepers G, Koopman P |title=Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. |journal=Dev. Biol. |volume=227 |issue= 2 |pages= 239-55 |year= 2001 |pmid= 11071752 |doi= 10.1006/dbio.2000.9883 }}
+* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = Aug 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }}
-*{{cite journal  | author=Wilson M, Koopman P |title=Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 4 |pages= 441-6 |year= 2003 |pmid= 12100890 |doi=  }}
+* {{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Research | volume = 20 | issue = 11 | pages = 2887 | date = Jun 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }}
-*{{cite journal  | author=Schepers GE, Teasdale RD, Koopman P |title=Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. |journal=Dev. Cell |volume=3 |issue= 2 |pages= 167-70 |year= 2002 |pmid= 12194848 |doi=  }}
+* {{cite journal | vauthors = Connor F, Cary PD, Read CM, Preston NS, Driscoll PC, Denny P, Crane-Robinson C, Ashworth A | title = DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5 | journal = Nucleic Acids Research | volume = 22 | issue = 16 | pages = 3339–46 | date = Aug 1994 | pmid = 8078769 | pmc = 523727 | doi = 10.1093/nar/22.16.3339 }}
-*{{cite journal  | author=Denny P, Swift S, Brand N, ''et al.'' |title=A conserved family of genes related to the testis determining gene, SRY. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2887 |year= 1992 |pmid= 1614875 |doi=  }}
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-*{{cite journal  | author=Connor F, Cary PD, Read CM, ''et al.'' |title=DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5. |journal=Nucleic Acids Res. |volume=22 |issue= 16 |pages= 3339-46 |year= 1994 |pmid= 8078769 |doi=  }}
+* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-*{{cite journal  | author=Wunderle VM, Critcher R, Ashworth A, Goodfellow PN |title=Cloning and characterization of SOX5, a new member of the human SOX gene family. |journal=Genomics |volume=36 |issue= 2 |pages= 354-8 |year= 1997 |pmid= 8812465 |doi= 10.1006/geno.1996.0474 }}
+* {{cite journal | vauthors = Lefebvre V, Li P, de Crombrugghe B | title = A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene | journal = The EMBO Journal | volume = 17 | issue = 19 | pages = 5718–33 | date = Oct 1998 | pmid = 9755172 | pmc = 1170900 | doi = 10.1093/emboj/17.19.5718 }}
-*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
+* {{cite journal | vauthors = Uusitalo H, Hiltunen A, Ahonen M, Gao TJ, Lefebvre V, Harley V, Kähäri VM, Vuorio E | title = Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing | journal = Journal of Bone and Mineral Research | volume = 16 | issue = 10 | pages = 1837–45 | date = Oct 2001 | pmid = 11585348 | doi = 10.1359/jbmr.2001.16.10.1837 }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal | vauthors = Zafarana G, Gillis AJ, van Gurp RJ, Olsson PG, Elstrodt F, Stoop H, Millán JL, Oosterhuis JW, Looijenga LH | title = Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation | journal = Cancer Research | volume = 62 | issue = 6 | pages = 1822–31 | date = Mar 2002 | pmid = 11912161 | doi =  }}
-*{{cite journal  | author=Lefebvre V, Li P, de Crombrugghe B |title=A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. |journal=EMBO J. |volume=17 |issue= 19 |pages= 5718-33 |year= 1998 |pmid= 9755172 |doi= 10.1093/emboj/17.19.5718 }}
+* {{cite journal | vauthors = Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S | title = Identification and characterization of the human long form of Sox5 (L-SOX5) gene | journal = Gene | volume = 298 | issue = 1 | pages = 59–68 | date = Sep 2002 | pmid = 12406576 | doi = 10.1016/S0378-1119(02)00927-7 }}
-*{{cite journal  | author=Uusitalo H, Hiltunen A, Ahonen M, ''et al.'' |title=Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing. |journal=J. Bone Miner. Res. |volume=16 |issue= 10 |pages= 1837-45 |year= 2002 |pmid= 11585348 |doi=  }}
-*{{cite journal  | author=Zafarana G, Gillis AJ, van Gurp RJ, ''et al.'' |title=Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. |journal=Cancer Res. |volume=62 |issue= 6 |pages= 1822-31 |year= 2002 |pmid= 11912161 |doi=  }}
-*{{cite journal  | author=Ikeda T, Zhang J, Chano T, ''et al.'' |title=Identification and characterization of the human long form of Sox5 (L-SOX5) gene. |journal=Gene |volume=298 |issue= 1 |pages= 59-68 |year= 2003 |pmid= 12406576 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-}}
 {{refend}}
+{{PDB Gallery|geneid=6660}}
+{{Transcription factors|g4}}
-{{protein-stub}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-12-stub}}

SOX5: Difference between revisions

Latest revision as of 06:51, 11 September 2017

Contents

Function

See also

References

Further reading

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