Retinoid X receptor gamma

Retinoid X receptor, gamma
File:PBB Protein RXRG image.jpg Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1by4​, 1dsz​, 1r0n​, 1rxr​, 2gl8​, 2nll​
Identifiers
Symbols	RXRG ; NR2B3; RXRC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21373
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RXRG 205954 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor encoded by the RXRG gene.

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

See also

• Retinoid X receptor

Further reading

• Szanto A, Narkar V, Shen Q; et al. (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions". Cell Death Differ. 11 Suppl 2: S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leid M, Kastner P, Lyons R; et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. PMID 1310259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mangelsdorf DJ, Borgmeyer U, Heyman RA; et al. (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid". Genes Dev. 6 (3): 329–44. PMID 1312497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagata T, Weiss EH, Abe K; et al. (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human". Immunogenetics. 41 (2–3): 83–90. PMID 7806300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Almasan A, Mangelsdorf DJ, Ong ES; et al. (1994). "Chromosomal localization of the human retinoid X receptors". Genomics. 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muscat GE, Mynett-Johnson L, Dowhan D; et al. (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. PMID 8127707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamei Y, Xu L, Heinzel T; et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell. 85 (3): 403–14. PMID 8616895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Sanno N, Sugawara A, Teramoto A; et al. (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology. 65 (4): 299–306. PMID 9143002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. PMID 9147069.CS1 maint: Multiple names: authors list (link)
• Xu XC, Sozzi G, Lee JS; et al. (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. PMID 9150186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yusta B, Alarid ET, Gordon DF; et al. (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology. 139 (11): 4476–82. PMID 9794455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito K, Suzuki T, Moriya T; et al. (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. PMID 11397877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim SW, Kim HJ, Jung DJ; et al. (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene. 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brabender J, Danenberg KD, Metzger R; et al. (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103.CS1 maint: Multiple names: authors list (link)
• Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta. 23 (8–9): 661–71. PMID 12361685.CS1 maint: Multiple names: authors list (link)
• Kimura Y, Suzuki T, Kaneko C; et al. (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. doi:10.1042/ . PMID 12444914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alfaro JM, Fraile B, Lobo MV; et al. (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. PMID 12514092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.