RUNX1T1

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
File:PBB Protein RUNX1T1 image.jpg PDB rendering based on 1wq6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wq6​, 2dj8​, 2h7b​
Identifiers
Symbols	RUNX1T1 ; AML1T1; CBFA2T1; CDR; ETO; MGC2796; MTG8; MTG8b; ZMYND2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3801
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RUNX1T1 205529 s at tn.png
File:PBB GE RUNX1T1 205528 s at tn.png
File:PBB GE RUNX1T1 216831 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related), also known as RUNX1T1, is a human gene.

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Further reading

• Ferrara F, Del Vecchio L (2002). "Acute myeloid leukemia with t(8;21)/AML1/ETO: a distinct biological and clinical entity". Haematologica. 87 (3): 306–19. PMID 11869944.
• Erickson P, Gao J, Chang KS; et al. (1992). "Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt". Blood. 80 (7): 1825–31. PMID 1391946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nisson PE, Watkins PC, Sacchi N (1992). "Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells". Cancer Genet. Cytogenet. 63 (2): 81–8. PMID 1423235.CS1 maint: Multiple names: authors list (link)
• Era T, Asou N, Kunisada T; et al. (1995). "Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells". Genes Chromosomes Cancer. 13 (1): 25–33. PMID 7541640.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tighe JE, Calabi F (1994). "Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2". Blood. 84 (7): 2115–21. PMID 7919324.
• Erickson PF, Robinson M, Owens G, Drabkin HA (1994). "The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor". Cancer Res. 54 (7): 1782–6. PMID 8137293.CS1 maint: Multiple names: authors list (link)
• Miyoshi H, Kozu T, Shimizu K; et al. (1993). "The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript". EMBO J. 12 (7): 2715–21. PMID 8334990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozu T, Miyoshi H, Shimizu K; et al. (1993). "Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction". Blood. 82 (4): 1270–6. PMID 8353289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Niwa-Kawakita M, Miyoshi H, Gotoh O; et al. (1996). "Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia". Genomics. 29 (3): 755–9. doi:10.1006/geno.1995.9941. PMID 8575770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Erickson PF, Dessev G, Lasher RS; et al. (1996). "ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease". Blood. 88 (5): 1813–23. PMID 8781439.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolford JK, Bogardus C, Prochazka M (1998). "Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males". Biochem. Biophys. Res. Commun. 246 (3): 624–6. doi:10.1006/bbrc.1998.8683. PMID 9618262.CS1 maint: Multiple names: authors list (link)
• Sacchi N, Tamanini F, Willemsen R; et al. (1998). "Subcellular localization of the oncoprotein MTG8 (CDR/ETO) in neural cells". Oncogene. 16 (20): 2609–15. doi:10.1038/sj.onc.1201824. PMID 9632137.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wolford JK, Prochazka M (1998). "Structure and expression of the human MTG8/ETO gene". Gene. 212 (1): 103–9. PMID 9661669.
• Calabi F, Cilli V (1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics. 52 (3): 332–41. doi:10.1006/geno.1998.5429. PMID 9790752.
• Komori A, Sueoka E, Fujiki H; et al. (1999). "Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines". Jpn. J. Cancer Res. 90 (1): 60–8. PMID 10076566.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morohoshi F, Mitani S, Mitsuhashi N; et al. (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95. PMID 10675041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Melnick AM, Westendorf JJ, Polinger A; et al. (2000). "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. PMID 10688654.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyamoto T, Weissman IL, Akashi K (2000). "AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7521–6. PMID 10861016.CS1 maint: Multiple names: authors list (link)
• Odaka Y, Mally A, Elliott LT, Meyers S (2000). "Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)". Oncogene. 19 (32): 3584–97. doi:10.1038/sj.onc.1203689. PMID 10951564.CS1 maint: Multiple names: authors list (link)
• Wood JD, Nucifora FC, Duan K; et al. (2000). "Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription". J. Cell Biol. 150 (5): 939–48. PMID 10973986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)