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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein PLAG1''' is a [[protein]] that in humans is encoded by the ''PLAG1'' [[gene]].<ref name="pmid9268638">{{cite journal | vauthors = Kas K, Röijer E, Voz M, Meyen E, Stenman G, Van de Ven WJ | title = A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands | journal = Genomics | volume = 43 | issue = 3 | pages = 349–58  | date = Nov 1997 | pmid = 9268638 | pmc =  | doi = 10.1006/geno.1997.4819 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLAG1 pleiomorphic adenoma gene 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5324| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pleiomorphic adenoma gene 1
| HGNCid = 9045
| Symbol = PLAG1
| AltSymbols =; PSA; SGPA
| OMIM = 603026
| ECnumber = 
| Homologene = 1993
| MGIid = 1891916
| GeneAtlas_image1 = PBB_GE_PLAG1_205372_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5324
    | Hs_Ensembl = ENSG00000181690
    | Hs_RefseqProtein = XP_001126483
    | Hs_RefseqmRNA = XM_001126483
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 57236037
    | Hs_GenLoc_end = 57286392
    | Hs_Uniprot = 
    | Mm_EntrezGene = 56711
    | Mm_Ensembl = ENSMUSG00000003282
    | Mm_RefseqmRNA = NM_019969
    | Mm_RefseqProtein = NP_064353
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 3829756
    | Mm_GenLoc_end = 3865529
    | Mm_Uniprot = 
  }}
}}
'''Pleiomorphic adenoma gene 1''', also known as '''PLAG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLAG1 pleiomorphic adenoma gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5324| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals.  PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands.  PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals.  PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands.  PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.<ref name="entrez">{{cite web | title = Entrez Gene: PLAG1 pleiomorphic adenoma gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5324| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PLAG1 has been shown to [[Protein-protein interaction|interact]] with [[Karyopherin alpha 2]].<ref name=pmid11882654>{{cite journal | vauthors = Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML | title = Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19673–8  | date = May 2002 | pmid = 11882654 | doi = 10.1074/jbc.M112112200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Van Dyck F, Declercq J, Braem CV, Van de Ven WJ | title = PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review) | journal = Int. J. Oncol. | volume = 30 | issue = 4 | pages = 765–74 | year = 2007 | pmid = 17332914 | doi = 10.3892/ijo.30.4.765 }}
| citations =
* {{cite journal | vauthors = Kas K, Voz ML, Röijer E, Aström AK, Meyen E, Stenman G, Van de Ven WJ | title = Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations | journal = Nat. Genet. | volume = 15 | issue = 2 | pages = 170–4 | year = 1997 | pmid = 9020842 | doi = 10.1038/ng0297-170 }}
*{{cite journal | author=Van Dyck F, Declercq J, Braem CV, Van de Ven WJ |title=PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review). |journal=Int. J. Oncol. |volume=30 |issue= 4 |pages= 765-74 |year= 2007 |pmid= 17332914 |doi= }}
* {{cite journal | vauthors = Voz ML, Aström AK, Kas K, Mark J, Stenman G, Van de Ven WJ | title = The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter | journal = Oncogene | volume = 16 | issue = 11 | pages = 1409–16 | year = 1998 | pmid = 9525740 | doi = 10.1038/sj.onc.1201660 }}
*{{cite journal | author=Kas K, Voz ML, Röijer E, ''et al.'' |title=Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. |journal=Nat. Genet. |volume=15 |issue= 2 |pages= 170-4 |year= 1997 |pmid= 9020842 |doi= 10.1038/ng0297-170 }}
* {{cite journal | vauthors = Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ | title = Transcriptional activation capacity of the novel PLAG family of zinc finger proteins | journal = J. Biol. Chem. | volume = 273 | issue = 36 | pages = 23026–32 | year = 1998 | pmid = 9722527 | doi = 10.1074/jbc.273.36.23026 }}
*{{cite journal | author=Kas K, Röijer E, Voz M, ''et al.'' |title=A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands. |journal=Genomics |volume=43 |issue= 3 |pages= 349-58 |year= 1997 |pmid= 9268638 |doi= 10.1006/geno.1997.4819 }}
* {{cite journal | vauthors = Aström AK, Voz ML, Kas K, Röijer E, Wedell B, Mandahl N, Van de Ven W, Mark J, Stenman G | title = Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene | journal = Cancer Res. | volume = 59 | issue = 4 | pages = 918–23 | year = 1999 | pmid = 10029085 | doi =  }}
*{{cite journal | author=Voz ML, Aström AK, Kas K, ''et al.'' |title=The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. |journal=Oncogene |volume=16 |issue= 11 |pages= 1409-16 |year= 1998 |pmid= 9525740 |doi= 10.1038/sj.onc.1201660 }}
* {{cite journal | vauthors = Voz ML, Agten NS, Van de Ven WJ, Kas K | title = PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II | journal = Cancer Res. | volume = 60 | issue = 1 | pages = 106–13 | year = 2000 | pmid = 10646861 | doi =  }}
*{{cite journal | author=Kas K, Voz ML, Hensen K, ''et al.'' |title=Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23026-32 |year= 1998 |pmid= 9722527 |doi=  }}
* {{cite journal | vauthors = Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML | title = Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19673–8 | year = 2002 | pmid = 11882654 | doi = 10.1074/jbc.M112112200 }}
*{{cite journal | author=Aström AK, Voz ML, Kas K, ''et al.'' |title=Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. |journal=Cancer Res. |volume=59 |issue= 4 |pages= 918-23 |year= 1999 |pmid= 10029085 |doi=  }}
* {{cite journal | vauthors = Hensen K, Van Valckenborgh IC, Kas K, Van de Ven WJ, Voz ML | title = The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities | journal = Cancer Res. | volume = 62 | issue = 5 | pages = 1510–7 | year = 2002 | pmid = 11888928 | doi = }}
*{{cite journal | author=Voz ML, Agten NS, Van de Ven WJ, Kas K |title=PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 106-13 |year= 2000 |pmid= 10646861 |doi= }}
* {{cite journal | vauthors = Enlund F, Nordkvist A, Sahlin P, Mark J, Stenman G | title = Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas | journal = Int. J. Oncol. | volume = 20 | issue = 4 | pages = 713–6 | year = 2002 | pmid = 11894114 | doi = 10.3892/ijo.20.4.713 }}
*{{cite journal | author=Braem CV, Kas K, Meyen E, ''et al.'' |title=Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19673-8 |year= 2002 |pmid= 11882654 |doi= 10.1074/jbc.M112112200 }}
* {{cite journal | vauthors = Zatkova A, Rouillard JM, Hartmann W, Lamb BJ, Kuick R, Eckart M, von Schweinitz D, Koch A, Fonatsch C, Pietsch T, Hanash SM, Wimmer K | title = Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma | journal = Genes Chromosomes Cancer | volume = 39 | issue = 2 | pages = 126–37 | year = 2004 | pmid = 14695992 | doi = 10.1002/gcc.10307 }}
*{{cite journal | author=Hensen K, Van Valckenborgh IC, Kas K, ''et al.'' |title=The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1510-7 |year= 2002 |pmid= 11888928 |doi= }}
* {{cite journal | vauthors = Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV | title = Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation | journal = J. Biol. Chem. | volume = 279 | issue = 34 | pages = 36121–31 | year = 2004 | pmid = 15208321 | doi = 10.1074/jbc.M401753200 }}
*{{cite journal | author=Enlund F, Nordkvist A, Sahlin P, ''et al.'' |title=Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. |journal=Int. J. Oncol. |volume=20 |issue= 4 |pages= 713-6 |year= 2002 |pmid= 11894114 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tsang YT, Chang YM, Lu X, Rao PH, Lau CC, Wong KK | title = Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification | journal = Cancer Genet. Cytogenet. | volume = 152 | issue = 2 | pages = 124–8 | year = 2004 | pmid = 15262430 | doi = 10.1016/j.cancergencyto.2003.12.001 }}
*{{cite journal | author=Zatkova A, Rouillard JM, Hartmann W, ''et al.'' |title=Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. |journal=Genes Chromosomes Cancer |volume=39 |issue= 2 |pages= 126-37 |year= 2004 |pmid= 14695992 |doi= 10.1002/gcc.10307 }}
* {{cite journal | vauthors = Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH | title = Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11 | journal = Blood | volume = 105 | issue = 7 | pages = 2900–7 | year = 2005 | pmid = 15585652 | doi = 10.1182/blood-2004-09-3630 }}
*{{cite journal | author=Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV |title=Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 36121-31 |year= 2005 |pmid= 15208321 |doi= 10.1074/jbc.M401753200 }}
* {{cite journal | vauthors = Morerio C, Rapella A, Rosanda C, Tassano E, Gambini C, Romagnoli G, Panarello C | title = PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement | journal = Cancer Genet. Cytogenet. | volume = 156 | issue = 2 | pages = 183–4 | year = 2005 | pmid = 15642402 | doi = 10.1016/j.cancergencyto.2004.04.017 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J | title = PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry | journal = Mod. Pathol. | volume = 18 | issue = 8 | pages = 1048–55 | year = 2005 | pmid = 15920557 | doi = 10.1038/modpathol.3800386 }}
*{{cite journal | author=Tsang YT, Chang YM, Lu X, ''et al.'' |title=Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification. |journal=Cancer Genet. Cytogenet. |volume=152 |issue= 2 |pages= 124-8 |year= 2004 |pmid= 15262430 |doi= 10.1016/j.cancergencyto.2003.12.001 }}
* {{cite journal | vauthors = Declercq J, Van Dyck F, Braem CV, Van Valckenborgh IC, Voz M, Wassef M, Schoonjans L, Van Damme B, Fiette L, Van de Ven WJ | title = Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression | journal = Cancer Res. | volume = 65 | issue = 11 | pages = 4544–53 | year = 2005 | pmid = 15930271 | doi = 10.1158/0008-5472.CAN-04-4041 }}
*{{cite journal | author=Landrette SF, Kuo YH, Hensen K, ''et al.'' |title=Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. |journal=Blood |volume=105 |issue= 7 |pages= 2900-7 |year= 2005 |pmid= 15585652 |doi= 10.1182/blood-2004-09-3630 }}
* {{cite journal | vauthors = Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z | title = Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice | journal = Int. J. Cancer | volume = 118 | issue = 3 | pages = 643–8 | year = 2006 | pmid = 16108035 | doi = 10.1002/ijc.21400 }}
*{{cite journal | author=Morerio C, Rapella A, Rosanda C, ''et al.'' |title=PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement. |journal=Cancer Genet. Cytogenet. |volume=156 |issue= 2 |pages= 183-4 |year= 2005 |pmid= 15642402 |doi= 10.1016/j.cancergencyto.2004.04.017 }}
*{{cite journal | author=Martins C, Fonseca I, Roque L, ''et al.'' |title=PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. |journal=Mod. Pathol. |volume=18 |issue= 8 |pages= 1048-55 |year= 2005 |pmid= 15920557 |doi= 10.1038/modpathol.3800386 }}
*{{cite journal  | author=Declercq J, Van Dyck F, Braem CV, ''et al.'' |title=Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. |journal=Cancer Res. |volume=65 |issue= 11 |pages= 4544-53 |year= 2005 |pmid= 15930271 |doi= 10.1158/0008-5472.CAN-04-4041 }}
*{{cite journal  | author=Zhao X, Ren W, Yang W, ''et al.'' |title=Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. |journal=Int. J. Cancer |volume=118 |issue= 3 |pages= 643-8 |year= 2006 |pmid= 16108035 |doi= 10.1002/ijc.21400 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|PLAG1+protein,+human}}
* {{MeshName|PLAG1+protein,+human}}


{{protein-stub}}
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{{Transcription factors}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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Latest revision as of 17:36, 30 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein PLAG1 is a protein that in humans is encoded by the PLAG1 gene.[1][2]

Function

Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.[2]

Interactions

PLAG1 has been shown to interact with Karyopherin alpha 2.[3]

References

  1. ↑ Kas K, Röijer E, Voz M, Meyen E, Stenman G, Van de Ven WJ (Nov 1997). "A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands". Genomics. 43 (3): 349–58. doi:10.1006/geno.1997.4819. PMID 9268638.
  2. ↑ 2.0 2.1 "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1".
  3. ↑ Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002). "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. doi:10.1074/jbc.M112112200. PMID 11882654.

Further reading

  • Van Dyck F, Declercq J, Braem CV, Van de Ven WJ (2007). "PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review)". Int. J. Oncol. 30 (4): 765–74. doi:10.3892/ijo.30.4.765. PMID 17332914.
  • Kas K, Voz ML, Röijer E, Aström AK, Meyen E, Stenman G, Van de Ven WJ (1997). "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations". Nat. Genet. 15 (2): 170–4. doi:10.1038/ng0297-170. PMID 9020842.
  • Voz ML, Aström AK, Kas K, Mark J, Stenman G, Van de Ven WJ (1998). "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene. 16 (11): 1409–16. doi:10.1038/sj.onc.1201660. PMID 9525740.
  • Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
  • Aström AK, Voz ML, Kas K, Röijer E, Wedell B, Mandahl N, Van de Ven W, Mark J, Stenman G (1999). "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene". Cancer Res. 59 (4): 918–23. PMID 10029085.
  • Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II". Cancer Res. 60 (1): 106–13. PMID 10646861.
  • Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (2002). "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. doi:10.1074/jbc.M112112200. PMID 11882654.
  • Hensen K, Van Valckenborgh IC, Kas K, Van de Ven WJ, Voz ML (2002). "The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities". Cancer Res. 62 (5): 1510–7. PMID 11888928.
  • Enlund F, Nordkvist A, Sahlin P, Mark J, Stenman G (2002). "Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas". Int. J. Oncol. 20 (4): 713–6. doi:10.3892/ijo.20.4.713. PMID 11894114.
  • Zatkova A, Rouillard JM, Hartmann W, Lamb BJ, Kuick R, Eckart M, von Schweinitz D, Koch A, Fonatsch C, Pietsch T, Hanash SM, Wimmer K (2004). "Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma". Genes Chromosomes Cancer. 39 (2): 126–37. doi:10.1002/gcc.10307. PMID 14695992.
  • Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV (2004). "Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation". J. Biol. Chem. 279 (34): 36121–31. doi:10.1074/jbc.M401753200. PMID 15208321.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Tsang YT, Chang YM, Lu X, Rao PH, Lau CC, Wong KK (2004). "Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification". Cancer Genet. Cytogenet. 152 (2): 124–8. doi:10.1016/j.cancergencyto.2003.12.001. PMID 15262430.
  • Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.
  • Morerio C, Rapella A, Rosanda C, Tassano E, Gambini C, Romagnoli G, Panarello C (2005). "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement". Cancer Genet. Cytogenet. 156 (2): 183–4. doi:10.1016/j.cancergencyto.2004.04.017. PMID 15642402.
  • Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J (2005). "PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry". Mod. Pathol. 18 (8): 1048–55. doi:10.1038/modpathol.3800386. PMID 15920557.
  • Declercq J, Van Dyck F, Braem CV, Van Valckenborgh IC, Voz M, Wassef M, Schoonjans L, Van Damme B, Fiette L, Van de Ven WJ (2005). "Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression". Cancer Res. 65 (11): 4544–53. doi:10.1158/0008-5472.CAN-04-4041. PMID 15930271.
  • Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z (2006). "Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice". Int. J. Cancer. 118 (3): 643–8. doi:10.1002/ijc.21400. PMID 16108035.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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