NFIA

Nuclear factor I/A
Identifiers
Symbols	NFIA ; DKFZp434L0422; KIAA1439; NFI-L
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4086
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nuclear factor I/A, also known as NFIA, is a human gene.

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM]

Further reading

• Qian F, Kruse U, Lichter P, Sippel AE (1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.CS1 maint: Multiple names: authors list (link)
• Leahy P, Crawford DR, Grossman G; et al. (1999). "CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription". J. Biol. Chem. 274 (13): 8813–22. PMID 10085123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• das Neves L, Duchala CS, Tolentino-Silva F; et al. (1999). "Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11946–51. PMID 10518556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu H, Uno JK, Inouye M; et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81. doi:10.1152/ajpgi.00396.2004. PMID 15458926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang W, Stock RE, Gronostajski RM; et al. (2005). "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression". J. Biol. Chem. 279 (51): 53491–7. doi:10.1074/jbc.M410370200. PMID 15466411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Champ PC, Maurice S, Vargason JM; et al. (2005). "Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation". Nucleic Acids Res. 32 (22): 6501–10. doi:10.1093/nar/gkh988. PMID 15598822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berry FB, O'Neill MA, Coca-Prados M, Walter MA (2005). "FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner". Mol. Cell. Biol. 25 (4): 1415–24. doi:10.1128/MCB.25.4.1415-1424.2005. PMID 15684392.CS1 maint: Multiple names: authors list (link)
• Fazi F, Rosa A, Fatica A; et al. (2006). "A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis". Cell. 123 (5): 819–31. doi:10.1016/j.cell.2005.09.023. PMID 16325577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin YL, Wang YH, Lee HJ (2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochem. Biophys. Res. Commun. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu W, Quintero-Rivera F, Fan Y; et al. (2007). "NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects". PLoS Genet. 3 (5): e80. doi:10.1371/journal.pgen.0030080. PMID 17530927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• NFIA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.