NFE2L2

Nuclear factor (erythroid-derived 2)-like 2
Identifiers
Symbols	NFE2L2 ; NRF2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2412
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NFE2L2 201146 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2, is a human gene.

NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995).[supplied by OMIM]

Further reading

• Alam J, Cook JL (2003). "Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway". Curr. Pharm. Des. 9 (30): 2499–511. PMID 14529549.
• Zhang DD (2007). "Mechanistic studies of the Nrf2-Keap1 signaling pathway". Drug Metab. Rev. 38 (4): 769–89. doi:10.1080/03602530600971974. PMID 17145701.
• Aleksunes LM, Manautou JE (2007). "Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease". Toxicologic pathology. 35 (4): 459–73. doi:10.1080/01926230701311344. PMID 17562481.
• Chan JY, Cheung MC, Moi P; et al. (1995). "Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization". Hum. Genet. 95 (3): 265–9. PMID 7868116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moi P, Chan K, Asunis I; et al. (1994). "Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region". Proc. Natl. Acad. Sci. U.S.A. 91 (21): 9926–30. PMID 7937919.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toki T, Itoh J, Kitazawa J; et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene. 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene. 17 (24): 3145–56. doi:10.1038/sj.onc.1202237. PMID 9872330.
• Itoh K, Wakabayashi N, Katoh Y; et al. (1999). "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain". Genes Dev. 13 (1): 76–86. PMID 9887101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Devereux W, Stewart TM, Casero RA (1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". J. Biol. Chem. 274 (31): 22095–101. PMID 10419538.CS1 maint: Multiple names: authors list (link)
• Ohtsubo T, Kamada S, Mikami T; et al. (2000). "Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases". Cell Death Differ. 6 (9): 865–72. doi:10.1038/sj.cdd.4400566. PMID 10510468.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen T, Huang HC, Pickett CB (2000). "Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK". J. Biol. Chem. 275 (20): 15466–73. doi:10.1074/jbc.M000361200. PMID 10747902.CS1 maint: Multiple names: authors list (link)
• Ikeda Y, Sugawara A, Taniyama Y; et al. (2000). "Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2". J. Biol. Chem. 275 (42): 33142–50. doi:10.1074/jbc.M002319200. PMID 10930400.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dhakshinamoorthy S, Jaiswal AK (2001). "Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene". J. Biol. Chem. 275 (51): 40134–41. doi:10.1074/jbc.M003531200. PMID 11013233.
• Huang HC, Nguyen T, Pickett CB (2001). "Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2". Proc. Natl. Acad. Sci. U.S.A. 97 (23): 12475–80. doi:10.1073/pnas.220418997. PMID 11035812.CS1 maint: Multiple names: authors list (link)
• Wang Y, Devereux W, Stewart TM, Casero RA (2001). "Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene". Biochem. J. 355 (Pt 1): 45–9. PMID 11256947.CS1 maint: Multiple names: authors list (link)
• He CH, Gong P, Hu B; et al. (2001). "Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation". J. Biol. Chem. 276 (24): 20858–65. doi:10.1074/jbc.M101198200. PMID 11274184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dhakshinamoorthy S, Jaiswal AK (2001). "Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene". Oncogene. 20 (29): 3906–17. doi:10.1038/sj.onc.1204506. PMID 11439354.
• Katoh Y, Itoh K, Yoshida E; et al. (2002). "Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription". Genes Cells. 6 (10): 857–68. PMID 11683914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Devereux W, Stewart TM, Casero RA (2002). "Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression". Biochem. J. 366 (Pt 1): 79–86. doi:10.1042/BJ20020211. PMID 12020345.CS1 maint: Multiple names: authors list (link)
• Tirumalai R, Rajesh Kumar T, Mai KH, Biswal S (2002). "Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells". Toxicol. Lett. 132 (1): 27–36. PMID 12084617.CS1 maint: Multiple names: authors list (link)

External links

• NFE2L2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.