NEUROD2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Neurogenic differentiation factor 2''' is a [[protein]] that in humans is encoded by the ''NEUROD2'' [[gene]].<ref name="pmid9119405">{{cite journal | vauthors = Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ | title = NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively | journal = Genomics | volume = 40 | issue = 2 | pages = 355–7 | date = Mar 1997 | pmid = 9119405 | pmc =  | doi = 10.1006/geno.1996.4578 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NEUROD2 neurogenic differentiation 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4761| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Neurogenic differentiation 2
| HGNCid = 7763
| Symbol = NEUROD2
| AltSymbols =; MGC26304; NDRF
| OMIM = 601725
| ECnumber = 
| Homologene = 4489
| MGIid = 107755
| GeneAtlas_image1 = PBB_GE_NEUROD2_210271_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001662 |text = behavioral fear response}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008306 |text = associative learning}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0048666 |text = neuron development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4761
    | Hs_Ensembl = ENSG00000171532
    | Hs_RefseqProtein = NP_006151
    | Hs_RefseqmRNA = NM_006160
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 35014577
    | Hs_GenLoc_end = 35017699
    | Hs_Uniprot = Q15784
    | Mm_EntrezGene = 18013
    | Mm_Ensembl = ENSMUSG00000038255
    | Mm_RefseqmRNA = NM_010895
    | Mm_RefseqProtein = NP_035025
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 98142680
    | Mm_GenLoc_end = 98145738
    | Mm_Uniprot = Q3TYB2
  }}
}}
'''Neurogenic differentiation 2''', also known as '''NEUROD2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NEUROD2 neurogenic differentiation 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4761| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.<ref name="entrez">{{cite web | title = Entrez Gene: NEUROD2 neurogenic differentiation 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4761| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
NEUROD2 has been shown to [[Protein-protein interaction|interact]] with [[Protein kinase N1]].<ref name=pmid10640683>{{cite journal | vauthors = Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y | title = Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 | journal = Brain Research. Molecular Brain Research | volume = 74 | issue = 1-2 | pages = 126–34 | date = Dec 1999 | pmid = 10640683 | doi = 10.1016/S0169-328X(99)00273-9 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ | title = NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family | journal = Molecular and Cellular Biology | volume = 16 | issue = 10 | pages = 5792–800 | date = Oct 1996 | pmid = 8816493 | pmc = 231580 | doi = 10.1128/mcb.16.10.5792}}
| citations =
* {{cite journal | vauthors = Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K | title = Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein | journal = Brain Research. Molecular Brain Research | volume = 60 | issue = 1 | pages = 107–14 | date = Sep 1998 | pmid = 9748526 | doi = 10.1016/S0169-328X(98)00176-4 }}
*{{cite journal | author=McCormick MB, Tamimi RM, Snider L, ''et al.'' |title=NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5792-800 |year= 1996 |pmid= 8816493 |doi=  }}
* {{cite journal | vauthors = Kitamura T, Miyachi T, Nakamura S, Kawakami H | title = Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1 | journal = Biochimica et Biophysica Acta | volume = 1445 | issue = 1 | pages = 142–7 | date = Apr 1999 | pmid = 10209266 | doi = 10.1016/s0167-4781(99)00038-x }}
*{{cite journal  | author=Tamimi RM, Steingrimsson E, Montgomery-Dyer K, ''et al.'' |title=NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. |journal=Genomics |volume=40 |issue= 2 |pages= 355-7 |year= 1997 |pmid= 9119405 |doi= 10.1006/geno.1996.4578 }}
* {{cite journal | vauthors = Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y | title = Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 | journal = Brain Research. Molecular Brain Research | volume = 74 | issue = 1-2 | pages = 126–34 | date = Dec 1999 | pmid = 10640683 | doi = 10.1016/S0169-328X(99)00273-9 }}
*{{cite journal | author=Kume H, Maruyama K, Shinozaki K, ''et al.'' |title=Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein. |journal=Brain Res. Mol. Brain Res. |volume=60 |issue= 1 |pages= 107-14 |year= 1998 |pmid= 9748526 |doi= }}
* {{cite journal | vauthors = Cousin P, Billotte J, Chaubert P, Shaw P | title = Physical map of 17p13 and the genes adjacent to p53 | journal = Genomics | volume = 63 | issue = 1 | pages = 60–8 | date = Jan 2000 | pmid = 10662545 | doi = 10.1006/geno.1999.6062 }}
*{{cite journal | author=Kitamura T, Miyachi T, Nakamura S, Kawakami H |title=Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1. |journal=Biochim. Biophys. Acta |volume=1445 |issue= 1 |pages= 142-7 |year= 1999 |pmid= 10209266 |doi= }}
* {{cite journal | vauthors = Franklin A, Kao A, Tapscott S, Unis A | title = NeuroD homologue expression during cortical development in the human brain | journal = Journal of Child Neurology | volume = 16 | issue = 11 | pages = 849–53 | date = Nov 2001 | pmid = 11732772 | doi = 10.1177/08830738010160111201 }}
*{{cite journal | author=Shibata H, Oda H, Mukai H, ''et al.'' |title=Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2. |journal=Brain Res. Mol. Brain Res. |volume=74 |issue= 1-2 |pages= 126-34 |year= 2000 |pmid= 10640683 |doi= }}
* {{cite journal | vauthors = Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB | title = The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion | journal = Mechanisms of Development | volume = 113 | issue = 1 | pages = 85–90 | date = Apr 2002 | pmid = 11900979 | doi = 10.1016/S0925-4773(01)00665-7 }}
*{{cite journal | author=Cousin P, Billotte J, Chaubert P, Shaw P |title=Physical map of 17p13 and the genes adjacent to p53. |journal=Genomics |volume=63 |issue= 1 |pages= 60-8 |year= 2000 |pmid= 10662545 |doi= 10.1006/geno.1999.6062 }}
* {{cite journal | vauthors = Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB | title = NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells | journal = Biochimica et Biophysica Acta | volume = 1676 | issue = 1 | pages = 96–103 | date = Jan 2004 | pmid = 14732494 | doi = 10.1016/j.bbaexp.2003.10.002 }}
*{{cite journal | author=Franklin A, Kao A, Tapscott S, Unis A |title=NeuroD homologue expression during cortical development in the human brain. |journal=J. Child Neurol. |volume=16 |issue= 11 |pages= 849-53 |year= 2002 |pmid= 11732772 |doi= }}
* {{cite journal | vauthors = Zill P, Büttner A, Eisenmenger W, Bondy B | title = A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior | journal = Molecular Psychiatry | volume = 11 | issue = 6 | pages = 525–7 | date = Jun 2006 | pmid = 16607387 | doi = 10.1038/sj.mp.4001825 }}
*{{cite journal | author=Westerman BA, Poutsma A, Maruyama K, ''et al.'' |title=The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion. |journal=Mech. Dev. |volume=113 |issue= 1 |pages= 85-90 |year= 2002 |pmid= 11900979 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Westerman BA, Chhatta A, Poutsma A, ''et al.'' |title=NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells. |journal=Biochim. Biophys. Acta |volume=1676 |issue= 1 |pages= 96-103 |year= 2004 |pmid= 14732494 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Zill P, Büttner A, Eisenmenger W, Bondy B |title=A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior. |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 525-7 |year= 2006 |pmid= 16607387 |doi= 10.1038/sj.mp.4001825 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|NEUROD2+protein,+human}}
* {{MeshName|NEUROD2+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
 
{{NLM content}}
{{DEFAULTSORT:Neurod2}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Human proteins]]
 
{{gene-17-stub}}

Latest revision as of 03:17, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.[1][2]

Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.[2]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.[3]

References

  1. ↑ Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
  2. ↑ 2.0 2.1 "Entrez Gene: NEUROD2 neurogenic differentiation 2".
  3. ↑ Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research. 74 (1–2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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