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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Metal regulatory transcription factor 1''' is a [[protein]] that in humans is encoded by the ''MTF1'' [[gene]].<ref name="pmid8065932">{{cite journal | vauthors = Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W | title = Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1 | journal = Nucleic Acids Research | volume = 22 | issue = 15 | pages = 3167–73 | date = Aug 1994 | pmid = 8065932 | pmc = 310292 | doi = 10.1093/nar/22.15.3167 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Metal-regulatory transcription factor 1
| HGNCid = 7428
| Symbol = MTF1
| AltSymbols =; MGC23036; MTF-1; ZRF
| OMIM = 600172
| ECnumber = 
| Homologene = 4347
| MGIid = 101786
| GeneAtlas_image1 = PBB_GE_MTF1_205323_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MTF1_205322_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0042156 |text = zinc-mediated transcriptional activator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0010038 |text = response to metal ion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4520
    | Hs_Ensembl = ENSG00000188786
    | Hs_RefseqProtein = NP_005946
    | Hs_RefseqmRNA = NM_005955
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 38052438
    | Hs_GenLoc_end = 38097879
    | Hs_Uniprot = Q14872
    | Mm_EntrezGene = 17764
    | Mm_Ensembl = ENSMUSG00000028890
    | Mm_RefseqmRNA = XM_622562
    | Mm_RefseqProtein = XP_622562
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 124304876
    | Mm_GenLoc_end = 124349954
    | Mm_Uniprot = Q80W60
  }}
}}
'''Metal-regulatory transcription factor 1''', also known as '''MTF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a [[metal-responsive element]] (MRE).<ref name="entrez">{{cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).<ref name="entrez">{{cite web | title = Entrez Gene: MTF1 metal-regulatory transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4520| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Westin G, Schaffner W | title = A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene | journal = The EMBO Journal | volume = 7 | issue = 12 | pages = 3763–70 | date = Dec 1988 | pmid = 3208749 | pmc = 454951 | doi =  }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Westin G, Schaffner W |title=A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. |journal=EMBO J. |volume=7 |issue= 12 |pages= 3763-70 |year= 1989 |pmid= 3208749 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Brugnera E, Georgiev O, Radtke F, ''et al.'' |title=Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. |journal=Nucleic Acids Res. |volume=22 |issue= 15 |pages= 3167-73 |year= 1994 |pmid= 8065932 |doi=  }}
* {{cite journal | vauthors = Chen X, Chu M, Giedroc DP | title = MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex | journal = Biochemistry | volume = 38 | issue = 39 | pages = 12915–25 | date = Sep 1999 | pmid = 10504263 | doi = 10.1021/bi9913000 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Otsuka F, Okugaito I, Ohsawa M, Iwamatsu A, Suzuki K, Koizumi S | title = Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals | journal = Biochimica et Biophysica Acta | volume = 1492 | issue = 2-3 | pages = 330–40 | date = Jul 2000 | pmid = 11004505 | doi = 10.1016/s0167-4781(00)00110-x }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Saydam N, Georgiev O, Nakano MY, Greber UF, Schaffner W | title = Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals | journal = The Journal of Biological Chemistry | volume = 276 | issue = 27 | pages = 25487–95 | date = Jul 2001 | pmid = 11306562 | doi = 10.1074/jbc.M009154200 }}
*{{cite journal | author=Chen X, Chu M, Giedroc DP |title=MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex. |journal=Biochemistry |volume=38 |issue= 39 |pages= 12915-25 |year= 1999 |pmid= 10504263 |doi= }}
* {{cite journal | vauthors = Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH | title = Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20438–45 | date = Jun 2002 | pmid = 11923282 | doi = 10.1074/jbc.M110631200 }}
*{{cite journal | author=Otsuka F, Okugaito I, Ohsawa M, ''et al.'' |title=Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 2-3 |pages= 330-40 |year= 2000 |pmid= 11004505 |doi= }}
* {{cite journal | vauthors = Majumder S, Ghoshal K, Summers D, Bai S, Datta J, Jacob ST | title = Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 26216–26 | date = Jul 2003 | pmid = 12716893 | pmc = 2365495 | doi = 10.1074/jbc.M302887200 }}
*{{cite journal | author=Saydam N, Georgiev O, Nakano MY, ''et al.'' |title=Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25487-95 |year= 2001 |pmid= 11306562 |doi= 10.1074/jbc.M009154200 }}
* {{cite journal | vauthors = Saydam N, Steiner F, Georgiev O, Schaffner W | title = Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | pages = 31879–83 | date = Aug 2003 | pmid = 12805380 | doi = 10.1074/jbc.M302138200 }}
*{{cite journal | author=Saydam N, Adams TK, Steiner F, ''et al.'' |title=Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20438-45 |year= 2002 |pmid= 11923282 |doi= 10.1074/jbc.M110631200 }}
* {{cite journal | vauthors = Chen X, Zhang B, Harmon PM, Schaffner W, Peterson DO, Giedroc DP | title = A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4515–22 | date = Feb 2004 | pmid = 14610091 | doi = 10.1074/jbc.M308924200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W | title = Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison | journal = Biological Chemistry | volume = 385 | issue = 7 | pages = 597–603 | date = Jul 2004 | pmid = 15318808 | doi = 10.1515/BC.2004.074 }}
*{{cite journal  | author=Majumder S, Ghoshal K, Summers D, ''et al.'' |title=Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26216-26 |year= 2003 |pmid= 12716893 |doi= 10.1074/jbc.M302887200 }}
* {{cite journal | vauthors = Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S | title = Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors | journal = Oncogene | volume = 24 | issue = 13 | pages = 2204–17 | date = Mar 2005 | pmid = 15735762 | doi = 10.1038/sj.onc.1208206 }}
*{{cite journal | author=Saydam N, Steiner F, Georgiev O, Schaffner W |title=Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 31879-83 |year= 2003 |pmid= 12805380 |doi= 10.1074/jbc.M302138200 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Chen X, Zhang B, Harmon PM, ''et al.'' |title=A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4515-22 |year= 2004 |pmid= 14610091 |doi= 10.1074/jbc.M308924200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Balamurugan K, Egli D, Selvaraj A, ''et al.'' |title=Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison. |journal=Biol. Chem. |volume=385 |issue= 7 |pages= 597-603 |year= 2005 |pmid= 15318808 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S |title=Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. |journal=Oncogene |volume=24 |issue= 13 |pages= 2204-17 |year= 2005 |pmid= 15735762 |doi= 10.1038/sj.onc.1208206 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|MTF1+protein,+human}}
* {{MeshName|MTF1+protein,+human}}


 
{{gene-1-stub}}
{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors|g2}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 02:12, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Metal regulatory transcription factor 1 is a protein that in humans is encoded by the MTF1 gene.[1][2]

Function

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).[2]

References

  1. ↑ Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W (Aug 1994). "Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1". Nucleic Acids Research. 22 (15): 3167–73. doi:10.1093/nar/22.15.3167. PMC 310292. PMID 8065932.
  2. ↑ 2.0 2.1 "Entrez Gene: MTF1 metal-regulatory transcription factor 1".

Further reading

  • Westin G, Schaffner W (Dec 1988). "A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene". The EMBO Journal. 7 (12): 3763–70. PMC 454951. PMID 3208749.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Chen X, Chu M, Giedroc DP (Sep 1999). "MRE-Binding transcription factor-1: weak zinc-binding finger domains 5 and 6 modulate the structure, affinity, and specificity of the metal-response element complex". Biochemistry. 38 (39): 12915–25. doi:10.1021/bi9913000. PMID 10504263.
  • Otsuka F, Okugaito I, Ohsawa M, Iwamatsu A, Suzuki K, Koizumi S (Jul 2000). "Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals". Biochimica et Biophysica Acta. 1492 (2–3): 330–40. doi:10.1016/s0167-4781(00)00110-x. PMID 11004505.
  • Saydam N, Georgiev O, Nakano MY, Greber UF, Schaffner W (Jul 2001). "Nucleo-cytoplasmic trafficking of metal-regulatory transcription factor 1 is regulated by diverse stress signals". The Journal of Biological Chemistry. 276 (27): 25487–95. doi:10.1074/jbc.M009154200. PMID 11306562.
  • Saydam N, Adams TK, Steiner F, Schaffner W, Freedman JH (Jun 2002). "Regulation of metallothionein transcription by the metal-responsive transcription factor MTF-1: identification of signal transduction cascades that control metal-inducible transcription". The Journal of Biological Chemistry. 277 (23): 20438–45. doi:10.1074/jbc.M110631200. PMID 11923282.
  • Majumder S, Ghoshal K, Summers D, Bai S, Datta J, Jacob ST (Jul 2003). "Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1". The Journal of Biological Chemistry. 278 (28): 26216–26. doi:10.1074/jbc.M302887200. PMC 2365495. PMID 12716893.
  • Saydam N, Steiner F, Georgiev O, Schaffner W (Aug 2003). "Heat and heavy metal stress synergize to mediate transcriptional hyperactivation by metal-responsive transcription factor MTF-1". The Journal of Biological Chemistry. 278 (34): 31879–83. doi:10.1074/jbc.M302138200. PMID 12805380.
  • Chen X, Zhang B, Harmon PM, Schaffner W, Peterson DO, Giedroc DP (Feb 2004). "A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo". The Journal of Biological Chemistry. 279 (6): 4515–22. doi:10.1074/jbc.M308924200. PMID 14610091.
  • Balamurugan K, Egli D, Selvaraj A, Zhang B, Georgiev O, Schaffner W (Jul 2004). "Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison". Biological Chemistry. 385 (7): 597–603. doi:10.1515/BC.2004.074. PMID 15318808.
  • Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (Mar 2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene. 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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