Liver X receptor beta

Nuclear receptor subfamily 1, group H, member 2
File:PBB Protein NR1H2 image.jpg PDB rendering based on 1p8d.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1p8d​, 1pq6​, 1pq9​, 1pqc​, 1upv​, 1upw​
Identifiers
Symbols	NR1H2 ; UNR; LXR-b; LXRB; NER; NER-I; RIP15
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21397
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NR1H2 218215 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).

The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM]

Further reading

• Song C, Hiipakka RA, Kokontis JM, Liao S (1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones". Ann. N. Y. Acad. Sci. 761: 38–49. PMID 7625741.CS1 maint: Multiple names: authors list (link)
• Seol W, Choi HS, Moore DD (1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Mol. Endocrinol. 9 (1): 72–85. PMID 7760852.CS1 maint: Multiple names: authors list (link)
• Le Beau MM, Song C, Davis EM; et al. (1995). "Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization". Genomics. 26 (1): 166–8. PMID 7782080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shinar DM, Endo N, Rutledge SJ; et al. (1994). "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor". Gene. 147 (2): 273–6. PMID 7926814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song C, Kokontis JM, Hiipakka RA, Liao S (1994). "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10809–13. PMID 7971966.CS1 maint: Multiple names: authors list (link)
• Janowski BA, Grogan MJ, Jones SA; et al. (1999). "Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 266–71. PMID 9874807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA (1999). "Identification of a novel DNA binding site for nuclear orphan receptor OR1". J. Biol. Chem. 274 (15): 10421–9. PMID 10187832.CS1 maint: Multiple names: authors list (link)
• Lee SK, Jung SY, Kim YS; et al. (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. PMID 11158331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitney KD, Watson MA, Goodwin B; et al. (2001). "Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages". J. Biol. Chem. 276 (47): 43509–15. doi:10.1074/jbc.M106155200. PMID 11546778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitney KD, Watson MA, Collins JL; et al. (2003). "Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system". Mol. Endocrinol. 16 (6): 1378–85. PMID 12040022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brendel C, Schoonjans K, Botrugno OA; et al. (2003). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. PMID 12198243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mo J, Fang SJ, Chen W, Blobe GC (2003). "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta". J. Biol. Chem. 277 (52): 50788–94. doi:10.1074/jbc.M210376200. PMID 12393874.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams S, Bledsoe RK, Collins JL; et al. (2003). "X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch". J. Biol. Chem. 278 (29): 27138–43. doi:10.1074/jbc.M302260200. PMID 12736258.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Färnegårdh M, Bonn T, Sun S; et al. (2003). "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands". J. Biol. Chem. 278 (40): 38821–8. doi:10.1074/jbc.M304842200. PMID 12819202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuchi J, Song C, Ko AL, Liao S (2004). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors". Steroids. 68 (7–8): 685–91. PMID 12957674.CS1 maint: Multiple names: authors list (link)
• Hoerer S, Schmid A, Heckel A; et al. (2004). "Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist". J. Mol. Biol. 334 (5): 853–61. PMID 14643652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walczak R, Joseph SB, Laffitte BA; et al. (2004). "Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors". J. Biol. Chem. 279 (11): 9905–11. doi:10.1074/jbc.M310587200. PMID 14699103.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.