Liver X receptor beta
Nuclear receptor subfamily 1, group H, member 2 | |||||||||||||
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File:PBB Protein NR1H2 image.jpg PDB rendering based on 1p8d. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | NR1H2 ; UNR; LXR-b; LXRB; NER; NER-I; RIP15 | ||||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 21397 | ||||||||||||
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RNA expression pattern | |||||||||||||
File:PBB GE NR1H2 218215 s at tn.png | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Template:GNF Ortholog box | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | n/a | n/a | |||||||||||
Ensembl | n/a | n/a | |||||||||||
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RefSeq (mRNA) | n/a | n/a | |||||||||||
RefSeq (protein) | n/a | n/a | |||||||||||
Location (UCSC) | n/a | n/a | |||||||||||
PubMed search | n/a | n/a |
Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[1]
The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM][1]
References
Further reading
- Song C, Hiipakka RA, Kokontis JM, Liao S (1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones". Ann. N. Y. Acad. Sci. 761: 38–49. PMID 7625741.
- Seol W, Choi HS, Moore DD (1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Mol. Endocrinol. 9 (1): 72–85. PMID 7760852.
- Le Beau MM, Song C, Davis EM; et al. (1995). "Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization". Genomics. 26 (1): 166–8. PMID 7782080.
- Shinar DM, Endo N, Rutledge SJ; et al. (1994). "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor". Gene. 147 (2): 273–6. PMID 7926814.
- Song C, Kokontis JM, Hiipakka RA, Liao S (1994). "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10809–13. PMID 7971966.
- Janowski BA, Grogan MJ, Jones SA; et al. (1999). "Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 266–71. PMID 9874807.
- Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA (1999). "Identification of a novel DNA binding site for nuclear orphan receptor OR1". J. Biol. Chem. 274 (15): 10421–9. PMID 10187832.
- Lee SK, Jung SY, Kim YS; et al. (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. PMID 11158331.
- Whitney KD, Watson MA, Goodwin B; et al. (2001). "Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages". J. Biol. Chem. 276 (47): 43509–15. doi:10.1074/jbc.M106155200. PMID 11546778.
- Whitney KD, Watson MA, Collins JL; et al. (2003). "Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system". Mol. Endocrinol. 16 (6): 1378–85. PMID 12040022.
- Brendel C, Schoonjans K, Botrugno OA; et al. (2003). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. PMID 12198243.
- Mo J, Fang SJ, Chen W, Blobe GC (2003). "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta". J. Biol. Chem. 277 (52): 50788–94. doi:10.1074/jbc.M210376200. PMID 12393874.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Williams S, Bledsoe RK, Collins JL; et al. (2003). "X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch". J. Biol. Chem. 278 (29): 27138–43. doi:10.1074/jbc.M302260200. PMID 12736258.
- Färnegårdh M, Bonn T, Sun S; et al. (2003). "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands". J. Biol. Chem. 278 (40): 38821–8. doi:10.1074/jbc.M304842200. PMID 12819202.
- Fukuchi J, Song C, Ko AL, Liao S (2004). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors". Steroids. 68 (7–8): 685–91. PMID 12957674.
- Hoerer S, Schmid A, Heckel A; et al. (2004). "Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist". J. Mol. Biol. 334 (5): 853–61. PMID 14643652.
- Walczak R, Joseph SB, Laffitte BA; et al. (2004). "Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors". J. Biol. Chem. 279 (11): 9905–11. doi:10.1074/jbc.M310587200. PMID 14699103.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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