Liver X receptor beta: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Liver X receptor beta''' ('''LXR-β''') is a member of the [[nuclear receptor]] family of [[transcription factors]].  LXR-β is encoded by the {{gene|NR1H2}} gene (nuclear receptor subfamily 1, group H, member 2).<ref name="entrez">{{cite web | title = Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1H2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p8d.
| PDB = {{PDB2|1p8d}}, {{PDB2|1pq6}}, {{PDB2|1pq9}}, {{PDB2|1pqc}}, {{PDB2|1upv}}, {{PDB2|1upw}}
| Name = Nuclear receptor subfamily 1, group H, member 2
| HGNCid = 7965
| Symbol = NR1H2
| AltSymbols =; UNR; LXR-b; LXRB; NER; NER-I; RIP15
| OMIM = 600380
| ECnumber = 
| Homologene = 21397
| MGIid = 1352463
| GeneAtlas_image1 = PBB_GE_NR1H2_218215_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7376
    | Hs_Ensembl = ENSG00000131408
    | Hs_RefseqProtein = NP_009052
    | Hs_RefseqmRNA = NM_007121
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 55571515
    | Hs_GenLoc_end = 55578030
    | Hs_Uniprot = P55055
    | Mm_EntrezGene = 22260
    | Mm_Ensembl = ENSMUSG00000060601
    | Mm_RefseqmRNA = XM_001002072
    | Mm_RefseqProtein = XP_001002072
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 44417659
    | Mm_GenLoc_end = 44421965
    | Mm_Uniprot = Q8BP65
  }}
}}
'''Liver X receptor beta''' ('''LXR-β''') is a member of the [[nuclear receptor]] family of [[transcription factors]].  LXR-β is encoded by the {{gene|NR1H2}} gene (nuclear receptor subfamily 1, group H, member 2).<ref name="entrez">{{cite web | title = Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
The [[liver X receptor]]s (LXRs) were originally identified as [[orphan receptor|orphan]] members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with [[retinoid X receptor]] and bind to specific [[response element]]s (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha ([[Liver X receptor alpha|LXRA]]) and beta, are known to encode LXR proteins.<ref name="entrez"/><ref name="pmid7625741">{{cite journal | vauthors = Song C, Hiipakka RA, Kokontis JM, Liao S | title = Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones | journal = Annals of the New York Academy of Sciences | volume = 761 | issue =  | pages = 38–49 | date = Jun 1995 | pmid = 7625741 | doi = 10.1111/j.1749-6632.1995.tb31367.x }}</ref>
| section_title =  
| summary_text = The LX receptors (LXRs) were originally identified as [[orphan receptor|orphan]] members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with [[retinoid X receptor]] (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376| accessdate = }}</ref>
}}


==References==
==Structure==
{{reflist|2}}
Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.<ref name="pmid24561505">{{cite journal | vauthors = Lou X, Toresson G, Benod C, Suh JH, Philips KJ, Webb P, Gustafsson JA | title = Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA | journal = Nature Structural & Molecular Biology | volume = 21 | issue = 3 | pages = 277–81 | date = Mar 2014 | pmid = 24561505 | doi = 10.1038/nsmb.2778 }}</ref>


==Further reading==
== Interactions ==
 
Liver X receptor beta has been shown to [[Protein-protein interaction|interact]] with [[NCOA6]]<ref name="pmid11158331">{{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Molecular Endocrinology | volume = 15 | issue = 2 | pages = 241–54 | date = Feb 2001 | pmid = 11158331 | doi = 10.1210/me.15.2.241 }}</ref> and [[Retinoid X receptor alpha]].<ref name="pmid7760852">{{cite journal | vauthors = Seol W, Choi HS, Moore DD | title = Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors | journal = Molecular Endocrinology | volume = 9 | issue = 1 | pages = 72–85 | date = Jan 1995 | pmid = 7760852 | doi = 10.1210/mend.9.1.7760852 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Seol W, Choi HS, Moore DD | title = Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors | journal = Molecular Endocrinology | volume = 9 | issue = 1 | pages = 72–85 | date = Jan 1995 | pmid = 7760852 | doi = 10.1210/mend.9.1.7760852 }}
| citations =
* {{cite journal | vauthors = Le Beau MM, Song C, Davis EM, Hiipakka RA, Kokontis JM, Liao S | title = Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization | journal = Genomics | volume = 26 | issue = 1 | pages = 166–8 | date = Mar 1995 | pmid = 7782080 | doi = 10.1016/0888-7543(95)80100-Z }}
*{{cite journal  | author=Song C, Hiipakka RA, Kokontis JM, Liao S |title=Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones. |journal=Ann. N. Y. Acad. Sci. |volume=761 |issue=  |pages= 38-49 |year= 1995 |pmid= 7625741 |doi=  }}
* {{cite journal | vauthors = Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A | title = NER, a new member of the gene family encoding the human steroid hormone nuclear receptor | journal = Gene | volume = 147 | issue = 2 | pages = 273–6 | date = Sep 1994 | pmid = 7926814 | doi = 10.1016/0378-1119(94)90080-9 }}
*{{cite journal | author=Seol W, Choi HS, Moore DD |title=Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 72-85 |year= 1995 |pmid= 7760852 |doi= }}
* {{cite journal | vauthors = Song C, Kokontis JM, Hiipakka RA, Liao S | title = Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 23 | pages = 10809–13 | date = Nov 1994 | pmid = 7971966 | pmc = 45115 | doi = 10.1073/pnas.91.23.10809 }}
*{{cite journal | author=Le Beau MM, Song C, Davis EM, ''et al.'' |title=Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization. |journal=Genomics |volume=26 |issue= 1 |pages= 166-8 |year= 1995 |pmid= 7782080 |doi= }}
* {{cite journal | vauthors = Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ | title = Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 1 | pages = 266–71 | date = Jan 1999 | pmid = 9874807 | pmc = 15128 | doi = 10.1073/pnas.96.1.266 }}
*{{cite journal | author=Shinar DM, Endo N, Rutledge SJ, ''et al.'' |title=NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. |journal=Gene |volume=147 |issue= 2 |pages= 273-6 |year= 1994 |pmid= 7926814 |doi= }}
* {{cite journal | vauthors = Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA | title = Identification of a novel DNA binding site for nuclear orphan receptor OR1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 15 | pages = 10421–9 | date = Apr 1999 | pmid = 10187832 | doi = 10.1074/jbc.274.15.10421 }}
*{{cite journal | author=Song C, Kokontis JM, Hiipakka RA, Liao S |title=Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 10809-13 |year= 1994 |pmid= 7971966 |doi= }}
* {{cite journal | vauthors = Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW | title = Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2 | journal = Molecular Endocrinology | volume = 15 | issue = 2 | pages = 241–54 | date = Feb 2001 | pmid = 11158331 | doi = 10.1210/me.15.2.241 }}
*{{cite journal | author=Janowski BA, Grogan MJ, Jones SA, ''et al.'' |title=Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 1 |pages= 266-71 |year= 1999 |pmid= 9874807 |doi= }}
* {{cite journal | vauthors = Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA | title = Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 43509–15 | date = Nov 2001 | pmid = 11546778 | doi = 10.1074/jbc.M106155200 }}
*{{cite journal | author=Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA |title=Identification of a novel DNA binding site for nuclear orphan receptor OR1. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10421-9 |year= 1999 |pmid= 10187832 |doi= }}
* {{cite journal | vauthors = Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, Kliewer SA | title = Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system | journal = Molecular Endocrinology | volume = 16 | issue = 6 | pages = 1378–85 | date = Jun 2002 | pmid = 12040022 | doi = 10.1210/me.16.6.1378 }}
*{{cite journal | author=Lee SK, Jung SY, Kim YS, ''et al.'' |title=Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. |journal=Mol. Endocrinol. |volume=15 |issue= 2 |pages= 241-54 |year= 2001 |pmid= 11158331 |doi= }}
* {{cite journal | vauthors = Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J | title = The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity | journal = Molecular Endocrinology | volume = 16 | issue = 9 | pages = 2065–76 | date = Sep 2002 | pmid = 12198243 | doi = 10.1210/me.2001-0194 }}
*{{cite journal | author=Whitney KD, Watson MA, Goodwin B, ''et al.'' |title=Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43509-15 |year= 2001 |pmid= 11546778 |doi= 10.1074/jbc.M106155200 }}
* {{cite journal | vauthors = Mo J, Fang SJ, Chen W, Blobe GC | title = Regulation of ALK-1 signaling by the nuclear receptor LXRbeta | journal = The Journal of Biological Chemistry | volume = 277 | issue = 52 | pages = 50788–94 | date = Dec 2002 | pmid = 12393874 | doi = 10.1074/jbc.M210376200 }}
*{{cite journal | author=Whitney KD, Watson MA, Collins JL, ''et al.'' |title=Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. |journal=Mol. Endocrinol. |volume=16 |issue= 6 |pages= 1378-85 |year= 2003 |pmid= 12040022 |doi= }}
* {{cite journal | vauthors = Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM | title = X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 27138–43 | date = Jul 2003 | pmid = 12736258 | doi = 10.1074/jbc.M302260200 }}
*{{cite journal | author=Brendel C, Schoonjans K, Botrugno OA, ''et al.'' |title=The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. |journal=Mol. Endocrinol. |volume=16 |issue= 9 |pages= 2065-76 |year= 2003 |pmid= 12198243 |doi= }}
* {{cite journal | vauthors = Färnegårdh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M | title = The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 38821–8 | date = Oct 2003 | pmid = 12819202 | doi = 10.1074/jbc.M304842200 }}
*{{cite journal | author=Mo J, Fang SJ, Chen W, Blobe GC |title=Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50788-94 |year= 2003 |pmid= 12393874 |doi= 10.1074/jbc.M210376200 }}
* {{cite journal | vauthors = Fukuchi J, Song C, Ko AL, Liao S | title = Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors | journal = Steroids | volume = 68 | issue = 7-8 | pages = 685–91 | date = Sep 2003 | pmid = 12957674 | doi = 10.1016/S0039-128X(03)00100-4 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hoerer S, Schmid A, Heckel A, Budzinski RM, Nar H | title = Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist | journal = Journal of Molecular Biology | volume = 334 | issue = 5 | pages = 853–61 | date = Dec 2003 | pmid = 14643652 | doi = 10.1016/j.jmb.2003.10.033 }}
*{{cite journal  | author=Williams S, Bledsoe RK, Collins JL, ''et al.'' |title=X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 27138-43 |year= 2003 |pmid= 12736258 |doi= 10.1074/jbc.M302260200 }}
* {{cite journal | vauthors = Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P | title = Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors | journal = The Journal of Biological Chemistry | volume = 279 | issue = 11 | pages = 9905–11 | date = Mar 2004 | pmid = 14699103 | doi = 10.1074/jbc.M310587200 }}
*{{cite journal | author=Färnegårdh M, Bonn T, Sun S, ''et al.'' |title=The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38821-8 |year= 2003 |pmid= 12819202 |doi= 10.1074/jbc.M304842200 }}
*{{cite journal | author=Fukuchi J, Song C, Ko AL, Liao S |title=Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors. |journal=Steroids |volume=68 |issue= 7-8 |pages= 685-91 |year= 2004 |pmid= 12957674 |doi= }}
*{{cite journal | author=Hoerer S, Schmid A, Heckel A, ''et al.'' |title=Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist. |journal=J. Mol. Biol. |volume=334 |issue= 5 |pages= 853-61 |year= 2004 |pmid= 14643652 |doi= }}
*{{cite journal | author=Walczak R, Joseph SB, Laffitte BA, ''et al.'' |title=Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 9905-11 |year= 2004 |pmid= 14699103 |doi= 10.1074/jbc.M310587200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}
{{-}}


{{NLM content}}  
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{PDB Gallery|geneid=7376}}
{{Transcription factors|g2}}
{{Nuclear receptor ligands}}


[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{gene-19-stub}}

Latest revision as of 00:47, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[1]

Function

The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.[1][2]

Structure

Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.[3]

Interactions

Liver X receptor beta has been shown to interact with NCOA6[4] and Retinoid X receptor alpha.[5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2".
  2. ↑ Song C, Hiipakka RA, Kokontis JM, Liao S (Jun 1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones". Annals of the New York Academy of Sciences. 761: 38–49. doi:10.1111/j.1749-6632.1995.tb31367.x. PMID 7625741.
  3. ↑ Lou X, Toresson G, Benod C, Suh JH, Philips KJ, Webb P, Gustafsson JA (Mar 2014). "Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA". Nature Structural & Molecular Biology. 21 (3): 277–81. doi:10.1038/nsmb.2778. PMID 24561505.
  4. ↑ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (Feb 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Molecular Endocrinology. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331.
  5. ↑ Seol W, Choi HS, Moore DD (Jan 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Molecular Endocrinology. 9 (1): 72–85. doi:10.1210/mend.9.1.7760852. PMID 7760852.

Further reading

  • Seol W, Choi HS, Moore DD (Jan 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Molecular Endocrinology. 9 (1): 72–85. doi:10.1210/mend.9.1.7760852. PMID 7760852.
  • Le Beau MM, Song C, Davis EM, Hiipakka RA, Kokontis JM, Liao S (Mar 1995). "Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization". Genomics. 26 (1): 166–8. doi:10.1016/0888-7543(95)80100-Z. PMID 7782080.
  • Shinar DM, Endo N, Rutledge SJ, Vogel R, Rodan GA, Schmidt A (Sep 1994). "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor". Gene. 147 (2): 273–6. doi:10.1016/0378-1119(94)90080-9. PMID 7926814.
  • Song C, Kokontis JM, Hiipakka RA, Liao S (Nov 1994). "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors". Proceedings of the National Academy of Sciences of the United States of America. 91 (23): 10809–13. doi:10.1073/pnas.91.23.10809. PMC 45115. PMID 7971966.
  • Janowski BA, Grogan MJ, Jones SA, Wisely GB, Kliewer SA, Corey EJ, Mangelsdorf DJ (Jan 1999). "Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 266–71. doi:10.1073/pnas.96.1.266. PMC 15128. PMID 9874807.
  • Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA (Apr 1999). "Identification of a novel DNA binding site for nuclear orphan receptor OR1". The Journal of Biological Chemistry. 274 (15): 10421–9. doi:10.1074/jbc.274.15.10421. PMID 10187832.
  • Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (Feb 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Molecular Endocrinology. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331.
  • Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA (Nov 2001). "Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages". The Journal of Biological Chemistry. 276 (47): 43509–15. doi:10.1074/jbc.M106155200. PMID 11546778.
  • Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, Kliewer SA (Jun 2002). "Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system". Molecular Endocrinology. 16 (6): 1378–85. doi:10.1210/me.16.6.1378. PMID 12040022.
  • Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
  • Mo J, Fang SJ, Chen W, Blobe GC (Dec 2002). "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta". The Journal of Biological Chemistry. 277 (52): 50788–94. doi:10.1074/jbc.M210376200. PMID 12393874.
  • Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM (Jul 2003). "X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch". The Journal of Biological Chemistry. 278 (29): 27138–43. doi:10.1074/jbc.M302260200. PMID 12736258.
  • Färnegårdh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M (Oct 2003). "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands". The Journal of Biological Chemistry. 278 (40): 38821–8. doi:10.1074/jbc.M304842200. PMID 12819202.
  • Fukuchi J, Song C, Ko AL, Liao S (Sep 2003). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors". Steroids. 68 (7–8): 685–91. doi:10.1016/S0039-128X(03)00100-4. PMID 12957674.
  • Hoerer S, Schmid A, Heckel A, Budzinski RM, Nar H (Dec 2003). "Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist". Journal of Molecular Biology. 334 (5): 853–61. doi:10.1016/j.jmb.2003.10.033. PMID 14643652.
  • Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P (Mar 2004). "Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors". The Journal of Biological Chemistry. 279 (11): 9905–11. doi:10.1074/jbc.M310587200. PMID 14699103.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=Liver_X_receptor_beta&oldid=1419346"