IKZF2

IKAROS family zinc finger 2 (Helios)
Identifiers
Symbols	IKZF2 ; HELIOS; MGC34330; ZNF1A2; ZNFN1A2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22659
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

IKAROS family zinc finger 2 (Helios), also known as IKZF2, is a human gene.

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Further reading

• Rebollo A, Schmitt C (2004). "Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies". Immunol. Cell Biol. 81 (3): 171–5. PMID 12752680.
• Sridharan R, Smale ST (2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes". J. Biol. Chem. 282 (41): 30227–38. doi:10.1074/jbc.M702541200. PMID 17681952.
• Tabayashi T, Ishimaru F, Takata M; et al. (2007). "Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies". Cancer Sci. 98 (2): 182–8. PMID 17297655.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun L, Kerawalla H, Wu X; et al. (2002). "Expression of a unique helios isoform in human leukemia cells". Leuk. Lymphoma. 43 (4): 841–9. PMID 12153174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Durand C, Kerfourn F, Charlemagne J, Fellah JS (2002). "Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors". Eur. J. Immunol. 32 (6): 1748–52. doi:10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B. PMID 12115658.CS1 maint: Multiple names: authors list (link)
• Nakase K, Ishimaru F, Fujii K; et al. (2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Exp. Hematol. 30 (4): 313–7. PMID 11937265.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perdomo J, Holmes M, Chong B, Crossley M (2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J. Biol. Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.CS1 maint: Multiple names: authors list (link)
• Hosokawa Y, Maeda Y, Seto M (1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern". Immunogenetics. 50 (1–2): 106–8. PMID 10541817.CS1 maint: Multiple names: authors list (link)
• Kelley CM, Ikeda T, Koipally J; et al. (1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Curr. Biol. 8 (9): 508–15. PMID 9560339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hahm K, Cobb BS, McCarty AS; et al. (1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes Dev. 12 (6): 782–96. PMID 9512513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IKZF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.