Hypertriglyceridemia omega-3 fatty acids: Difference between revisions

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{{Hypertriglyceridemia}}
__NOTOC__
{{Hyperlipoproteinemia}}


'''For full Omega-3 fatty acid drug info click [[Omega-3 fatty acid|here]]'''
'''For full Omega-3 fatty acid drug info click [[Omega-3 fatty acid|here]]'''


{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh@perfuse.org]
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com]


==Overview==
==Overview==
Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the [[diet (nutrition)|diet]], as well as with [[niacin]], [[fibrate]]s and [[statin]]s (three classes of drugs).  Increased [[fish oil]] intake may substantially lower an individual's triglycerides.<ref>{{cite web |url=http://www.lipidsonline.org/slides/slide01.cfm?q=hypertriglyceridemia&dpg=13 |title=Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin | format= |work=}}</ref><ref name="pmid2035283">{{cite journal |author=Terres W, Beil U, Reimann B, Tiede S, Bleifeld W |title=[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study] |language=German |journal=Zeitschrift für Kardiologie |volume=80 |issue=1 |pages=20-4 |year=1991 |pmid=2035283 |doi=}}</ref><ref>{{cite web |url=http://www.findarticles.com/p/articles/mi_m0887/is_n4_v9/ai_8960077 |title=Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles |format= |work=}}</ref>.  
Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the [[diet (nutrition)|diet]], as well as with [[niacin]], [[fibrate]]s and [[statin]]s (three classes of drugs).  Increased [[fish oil]] intake may substantially lower an individual's triglycerides.<ref>{{cite web |url=http://www.lipidsonline.org/slides/slide01.cfm?q=hypertriglyceridemia&dpg=13 |title=Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin | format= |work=}}</ref><ref name="pmid2035283">{{cite journal |author=Terres W, Beil U, Reimann B, Tiede S, Bleifeld W |title=[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study] |language=German |journal=Zeitschrift für Kardiologie |volume=80 |issue=1 |pages=20-4 |year=1991 |pmid=2035283 |doi=}}</ref><ref>{{cite web |url=http://www.findarticles.com/p/articles/mi_m0887/is_n4_v9/ai_8960077 |title=Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles |format= |work=}}</ref>.  


===Trial supportive data===
===Trial Supportive Data===


{|border="1" align="center" style="background:lightskyblue"
{|border="1" align="center" style="background:light gray"
|-
|-
| bgcolor="CadetBlue" |'''Study name'''
| bgcolor="Gray" |'''Study name'''
| bgcolor="CadetBlue" |'''Source & year'''
| bgcolor="Gray" |'''Source & year'''
| bgcolor="CadetBlue" |'''Study question'''
| bgcolor="Gray" |'''Study question'''
| bgcolor="CadetBlue" |'''Study Design'''
| bgcolor="Gray" |'''Study Design'''
| bgcolor="CadetBlue" |'''Study Population'''
| bgcolor="Gray" |'''Study Population'''
| bgcolor="CadetBlue" |'''Time period'''
| bgcolor="Gray" |'''Time period'''
| bgcolor="CadetBlue" |'''Intervention'''
| bgcolor="Gray" |'''Intervention'''
| bgcolor="CadetBlue" |'''Results'''
| bgcolor="Gray" |'''Results'''
| bgcolor="CadetBlue" |'''Conclusions'''
| bgcolor="Gray" |'''Conclusions'''
|-
|-
| Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }} </ref>
| Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }} </ref>
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*Decrease in very low-density lipoprotein ([[VLDL]]) cholesterol by 30-40% (p<0.005)
*Decrease in very low-density lipoprotein ([[VLDL]]) cholesterol by 30-40% (p<0.005)
|  
|  
* [[Omacor]] combination with [[simvastatin]] (concentrated source of [[omega-3 fatty acid]]s) was found to be a safe and effective in decreasing serum [[triglycerides]] level in a study over one year in [[coronary heart disease]] patients and [[hypertriglyceridemia]]
* [[Omacor]] combination with [[simvastatin]] was found to be a safe and effective in decreasing serum [[triglycerides]] in [[coronary heart disease]]  
|-
|-
|}
|}


==External links==
 
 
{{#ev:youtube|9l94Nm241GI}}
 
===Researchers say diets rich in Omega-3 fatty acids can help people with heart disease live longer, but why these oils are so beneficial remains unclear. A new study looks at how higher fish oil levels in the blood may protect the caps on chromosomes, which help measure biological aging===
 
==External Links==
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184


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{{Reflist|2}}
{{Reflist|2}}


[[fr:Hypertriglycéridémie]]
{{Lipopedia}}
[[pt:Hipertrigliceridemia]]


[[Category:Lipopedia]]
[[Category:Cardiology]]
[[Category:Cardiology]]
[[Category:Dermatology]]
[[Category:Dermatology]]

Latest revision as of 19:58, 23 November 2016

Lipoprotein Disorders Main Page

Hyperlipoproteinemia Microchapters

Hypercholesterolemia Patient Information

Hypertriglyceridemia Patient Information

Overview

Classification

Familial hyperchylomicronemia
Familial hypercholesterolemia
Familial combined hyperlipidemia
Dysbetalipoproteinemia
Primary hypertriglyceridemia
Mixed hyperlipoproteinemia

Differential Diagnosis

Screening

ACC/AHA Guideline Recommendations

Summary

Treatment

Major recommendations for statin therapy

Therapeutic response to statin therapy

Blood cholesterol LDL and non-HDL treatment goals

Treatment in heart failure and hemodialysis

Primary prevention

Secondary prevention

Intensity of statin therapy in primary and secondary prevention

Safety Recommendations

Guideline on Lifestyle Management

For full Omega-3 fatty acid drug info click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].

Trial Supportive Data

Study name Source & year Study question Study Design Study Population Time period Intervention Results Conclusions
Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia [4] Heart, 2001 To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia Double blinded randomized controlled trial 59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l 1 year Omacor (84% omega-3 fatty acid) 2 g BD or placebo
  • Decrease in serum triglycerides by 20-30% (p<0.005)
  • Decrease in very low-density lipoprotein (VLDL) cholesterol by 30-40% (p<0.005)


{{#ev:youtube|9l94Nm241GI}}

Researchers say diets rich in Omega-3 fatty acids can help people with heart disease live longer, but why these oils are so beneficial remains unclear. A new study looks at how higher fish oil levels in the blood may protect the caps on chromosomes, which help measure biological aging

External Links

http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184

References

  1. ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
  2. ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
  3. ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
  4. ↑ Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.


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