HOXD8: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-D8''' is a [[protein]] that in humans is encoded by the ''HOXD8'' [[gene]].<ref name="pmid1973146">{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc =  | doi =10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc =  | doi =10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Homeobox D8
| HGNCid = 5139
| Symbol = HOXD8
| AltSymbols =; HOX4; HOX4E; HOX5.4
| OMIM = 142985
| ECnumber = 
| Homologene = 10473
| MGIid = 96209
  | GeneAtlas_image1 = PBB_GE_HOXD8_gnf1h00326_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008595 |text = determination of anterior/posterior axis, embryo}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3234
    | Hs_Ensembl = ENSG00000175879
    | Hs_RefseqProtein = XP_001132822
    | Hs_RefseqmRNA = XM_001132822
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 176702714
    | Hs_GenLoc_end = 176704977
    | Hs_Uniprot = P13378
    | Mm_EntrezGene = 15437
    | Mm_Ensembl = ENSMUSG00000027102
    | Mm_RefseqmRNA = XM_355338
    | Mm_RefseqProtein = XP_355338
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 74506387
    | Mm_GenLoc_end = 74508093
    | Mm_Uniprot = Q9CUH8
  }}
}}
'''Homeobox D8''', also known as '''HOXD8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD8 homeobox D8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3234| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD8 homeobox D8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3234| accessdate = }}</ref>
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD8 homeobox D8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3234| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Goodman FR |title=Limb malformations and the human HOX genes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256-65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776 }}
*{{cite journal  | author=Goodman FR |title=Limb malformations and the human HOX genes. |journal=Am. J. Med. Genet. |volume=112 |issue= 3 |pages= 256–65 |year= 2003 |pmid= 12357469 |doi= 10.1002/ajmg.10776 }}
*{{cite journal  | author=Redline RW, Williams AJ, Patterson P, Collins T |title=Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. |journal=Genomics |volume=13 |issue= 2 |pages= 425-30 |year= 1992 |pmid= 1351871 |doi= }}
*{{cite journal  |vauthors=Redline RW, Williams AJ, Patterson P, Collins T |title=Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. |journal=Genomics |volume=13 |issue= 2 |pages= 425–30 |year= 1992 |pmid= 1351871 |doi=10.1016/0888-7543(92)90263-R }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
*{{cite journal   |vauthors=Oliver G, Sidell N, Fiske W, etal |title=Complementary homeo protein gradients in developing limb buds. |journal=Genes Dev. |volume=3 |issue= 5 |pages= 641–50 |year= 1989 |pmid= 2568311 |doi=10.1101/gad.3.5.641 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi= }}
*{{cite journal  |vauthors=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34–47 |year= 1996 |pmid= 7501971 |doi=10.1159/000217965 }}
*{{cite journal | author=Oliver G, Sidell N, Fiske W, ''et al.'' |title=Complementary homeo protein gradients in developing limb buds. |journal=Genes Dev. |volume=3 |issue= 5 |pages= 641-50 |year= 1989 |pmid= 2568311 |doi=  }}
*{{cite journal   |vauthors=Guazzi S, Lonigro R, Pintonello L, etal |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi= | pmc=395231 }}
*{{cite journal  | author=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34-47 |year= 1996 |pmid= 7501971 |doi=  }}
*{{cite journal  |vauthors=Rosen DR, Brown RH |title=Dinucleotide repeat polymorphism in the HOX4E locus |journal=Hum. Mol. Genet. |volume=2 |issue= 5 |pages= 617 |year= 1993 |pmid= 8100165 |doi=10.1093/hmg/2.5.617 }}
*{{cite journal | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
*{{cite journal   |vauthors=Del Campo M, Jones MC, Veraksa AN, etal |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=10.1086/302467  | pmc=1378080 }}
*{{cite journal  | author=Rosen DR, Brown RH |title=Dinucleotide repeat polymorphism in the HOX4E locus. |journal=Hum. Mol. Genet. |volume=2 |issue= 5 |pages= 617 |year= 1993 |pmid= 8100165 |doi=  }}
*{{cite journal  |vauthors=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1 |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1–2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=10.1159/000015651 }}
*{{cite journal | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi=  }}
*{{cite journal   |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal  | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
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* {{MeshName|HOXD8+protein,+human}}
* {{MeshName|HOXD8+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}
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Latest revision as of 14:02, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[3]

References

  1. ↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXD8 homeobox D8".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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