HOXC13: Difference between revisions

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Latest revision as of 02:26, 27 October 2017

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.^[1]^[2]^[3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.^[3]

References

↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
↑ ^3.0 ^3.1 "Entrez Gene: HOXC13 homeobox C13".

Godwin AR, Capecchi MR (Dec 1999). "Hair defects in Hoxc13 mutant mice". The Journal of Investigative Dermatology. Symposium Proceedings. 4 (3): 244–7. doi:10.1038/sj.jidsp.5640221. PMID 10674376.
Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B (Jan 2003). "Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)". Genes, Chromosomes & Cancer. 36 (1): 107–12. doi:10.1002/gcc.10139. PMID 12461755.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (Oct 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G (Jun 2000). "Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology. 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276.
Kulessa H, Turk G, Hogan BL (Dec 2000). "Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle". The EMBO Journal. 19 (24): 6664–74. doi:10.1093/emboj/19.24.6664. PMC 305899. PMID 11118201.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Pruett ND, Tkatchenko TV, Jave-Suarez L, Jacobs DF, Potter CS, Tkatchenko AV, Schweizer J, Awgulewitsch A (Dec 2004). "Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13". The Journal of Biological Chemistry. 279 (49): 51524–33. doi:10.1074/jbc.M404331200. PMID 15385554.

External links

HOXC13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[pmid1973146-1] McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[pmid1358459-2] Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.

[entrez-3] 3.0 ^3.1 "Entrez Gene: HOXC13 homeobox C13".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Homeobox protein Hox-C13''' is a [[protein]] that in humans is encoded by the ''HOXC13'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc =  | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXC13 homeobox C13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3229| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Homeobox C13
- | HGNCid = 5125
- | Symbol = HOXC13
- | AltSymbols =; HOX3; HOX3G
- | OMIM = 142976
- | ECnumber =
- | Homologene = 7770
- | MGIid = 99560
- | GeneAtlas_image1 = PBB_GE_HOXC13_219832_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3229
-    | Hs_Ensembl = ENSG00000123364
-    | Hs_RefseqProtein = NP_059106
-    | Hs_RefseqmRNA = NM_017410
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 52618843
-    | Hs_GenLoc_end = 52626594
-    | Hs_Uniprot = P31276
-    | Mm_EntrezGene = 15422
-    | Mm_Ensembl = ENSMUSG00000001655
-    | Mm_RefseqmRNA = NM_010464
-    | Mm_RefseqProtein = NP_034594
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 102749165
-    | Mm_GenLoc_end = 102756848
-    | Mm_Uniprot = P50207
-  }}
-}}
-'''Homeobox C13''', also known as '''HOXC13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXC13 homeobox C13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3229| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.<ref name="entrez">{{cite web | title = Entrez Gene: HOXC13 homeobox C13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3229| accessdate = }}</ref>
-}}
-==See also==
+== See also ==
 * [[Homeobox]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Godwin AR, Capecchi MR | title = Hair defects in Hoxc13 mutant mice | journal = The Journal of Investigative Dermatology. Symposium Proceedings | volume = 4 | issue = 3 | pages = 244–7 | date = Dec 1999 | pmid = 10674376 | doi = 10.1038/sj.jidsp.5640221 }}
-| citations =
+* {{cite journal | vauthors = Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B | title = Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13) | journal = Genes, Chromosomes & Cancer | volume = 36 | issue = 1 | pages = 107–12 | date = Jan 2003 | pmid = 12461755 | doi = 10.1002/gcc.10139 }}
-*{{cite journal  | author=Godwin AR, Capecchi MR |title=Hair defects in Hoxc13 mutant mice. |journal=J. Investig. Dermatol. Symp. Proc. |volume=4 |issue= 3 |pages= 244-7 |year= 2000 |pmid= 10674376 |doi=  }}
+* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
-*{{cite journal  | author=Panagopoulos I, Isaksson M, Billström R, ''et al.'' |title=Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13). |journal=Genes Chromosomes Cancer |volume=36 |issue= 1 |pages= 107-12 |year= 2003 |pmid= 12461755 |doi= 10.1002/gcc.10139 }}
+* {{cite journal | vauthors = Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH | title = Cognate homeo-box loci mapped on homologous human and mouse chromosomes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 23 | pages = 9104–8 | date = Dec 1986 | pmid = 2878432 | pmc = 387083 | doi = 10.1073/pnas.83.23.9104 }}
-*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
+* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenetics and Cell Genetics | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
-*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
+* {{cite journal | vauthors = Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B | title = Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines | journal = FEBS Letters | volume = 415 | issue = 3 | pages = 263–7 | date = Oct 1997 | pmid = 9357979 | doi = 10.1016/S0014-5793(97)01118-6 }}
-*{{cite journal  | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
+* {{cite journal | vauthors = de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G | title = Selection of homeotic proteins for binding to a human DNA replication origin | journal = Journal of Molecular Biology | volume = 299 | issue = 3 | pages = 667–80 | date = Jun 2000 | pmid = 10835276 | doi = 10.1006/jmbi.2000.3782 }}
-*{{cite journal  | author=Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH |title=Cognate homeo-box loci mapped on homologous human and mouse chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9104-8 |year= 1987 |pmid= 2878432 |doi=  }}
+* {{cite journal | vauthors = Kulessa H, Turk G, Hogan BL | title = Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle | journal = The EMBO Journal | volume = 19 | issue = 24 | pages = 6664–74 | date = Dec 2000 | pmid = 11118201 | pmc = 305899 | doi = 10.1093/emboj/19.24.6664 }}
-*{{cite journal  | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi=  }}
+* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
-*{{cite journal  | author=Flagiello D, Gibaud A, Dutrillaux B, ''et al.'' |title=Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. |journal=FEBS Lett. |volume=415 |issue= 3 |pages= 263-7 |year= 1997 |pmid= 9357979 |doi=  }}
+* {{cite journal | vauthors = Pruett ND, Tkatchenko TV, Jave-Suarez L, Jacobs DF, Potter CS, Tkatchenko AV, Schweizer J, Awgulewitsch A | title = Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 49 | pages = 51524–33 | date = Dec 2004 | pmid = 15385554 | doi = 10.1074/jbc.M404331200 }}
-*{{cite journal  | author=de Stanchina E, Gabellini D, Norio P, ''et al.'' |title=Selection of homeotic proteins for binding to a human DNA replication origin. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 667-80 |year= 2000 |pmid= 10835276 |doi= 10.1006/jmbi.2000.3782 }}
-*{{cite journal  | author=Kulessa H, Turk G, Hogan BL |title=Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6664-74 |year= 2001 |pmid= 11118201 |doi= 10.1093/emboj/19.24.6664 }}
-*{{cite journal  | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Pruett ND, Tkatchenko TV, Jave-Suarez L, ''et al.'' |title=Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51524-33 |year= 2005 |pmid= 15385554 |doi= 10.1074/jbc.M404331200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-}}
 {{refend}}
@@ Line 86: / Line 30: @@
 {{NLM content}}
-{{protein-stub}}
-{{Transcription factors}}
+{{Transcription factors|g3}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-12-stub}}

HOXC13: Difference between revisions

Latest revision as of 02:26, 27 October 2017

Contents

Function

See also

References

Further reading

External links

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