HOXB8: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-B8''' is a [[protein]] that in humans is encoded by the ''HOXB8'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB8 homeobox B8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox B8
| HGNCid = 5119
| Symbol = HOXB8
| AltSymbols =; HOX2; HOX2D; Hox-2.4
| OMIM = 142963
| ECnumber = 
| Homologene = 7768
| MGIid = 96189
| GeneAtlas_image1 = PBB_GE_HOXB8_221278_at_tn.png
| GeneAtlas_image2 = PBB_GE_HOXB8_204778_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3218
    | Hs_Ensembl = ENSG00000120068
    | Hs_RefseqProtein = NP_076921
    | Hs_RefseqmRNA = NM_024016
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 44044707
    | Hs_GenLoc_end = 44047300
    | Hs_Uniprot = P17481
    | Mm_EntrezGene = 15416
    | Mm_Ensembl = ENSMUSG00000056648
    | Mm_RefseqmRNA = NM_010461
    | Mm_RefseqProtein = NP_034591
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96099053
    | Mm_GenLoc_end = 96100560
    | Mm_Uniprot = P09632
  }}
}}
'''Homeobox B8''', also known as '''HOXB8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXB8 homeobox B8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a [[homeobox]] DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see {{section link|Homology (biology)|Orthology}}) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB8 homeobox B8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB8 homeobox B8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3218| accessdate = }}</ref>
}}


==See also==
[[Organ transplantation|Transplantation]] of normal (wild-type) [[bone marrow]] into a ''Hoxb8'' [[mutant]] mouse results in a reduction of compulsive grooming.<ref>{{cite journal | vauthors = Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR | title = Hematopoietic origin of pathological grooming in Hoxb8 mutant mice | journal = Cell | volume = 141 | issue = 5 | pages = 775–85 | date = May 2010 | pmid = 20510925 | pmc = 2894573 | doi = 10.1016/j.cell.2010.03.055 }}</ref>
 
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation; Research in Biological Diversity | volume = 45 | issue = 1 | pages = 61–9 | date = Oct 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
| citations =
* {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation; Research in Biological Diversity | volume = 40 | issue = 3 | pages = 191–7 | date = Jun 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal | author=Peverali FA, D'Esposito M, Acampora D, ''et al.'' |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61-9 |year= 1991 |pmid= 1981366 |doi= }}
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenetics and Cell Genetics | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
*{{cite journal | author=Giampaolo A, Acampora D, Zappavigna V, ''et al.'' |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191-7 |year= 1989 |pmid= 2570724 |doi= }}
* {{cite journal | vauthors = Vider BZ, Zimber A, Hirsch D, Estlein D, Chastre E, Prevot S, Gespach C, Yaniv A, Gazit A | title = Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression | journal = Biochemical and Biophysical Research Communications | volume = 232 | issue = 3 | pages = 742–8 | date = Mar 1997 | pmid = 9126347 | doi = 10.1006/bbrc.1997.6364 }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = Mar 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T | title = Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes | journal = Experimental Hematology | volume = 29 | issue = 7 | pages = 856–63 | date = Jul 2001 | pmid = 11438208 | doi = 10.1016/S0301-472X(01)00655-5 }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Knoepfler PS, Sykes DB, Pasillas M, Kamps MP | title = HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation | journal = Oncogene | volume = 20 | issue = 39 | pages = 5440–8 | date = Sep 2001 | pmid = 11571641 | doi = 10.1038/sj.onc.1204710 }}
*{{cite journal | author=Vider BZ, Zimber A, Hirsch D, ''et al.'' |title=Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 3 |pages= 742-8 |year= 1997 |pmid= 9126347 |doi= 10.1006/bbrc.1997.6364 }}
* {{cite journal | vauthors = Greer JM, Capecchi MR | title = Hoxb8 is required for normal grooming behavior in mice | journal = Neuron | volume = 33 | issue = 1 | pages = 23–34 | date = Jan 2002 | pmid = 11779477 | doi = 10.1016/S0896-6273(01)00564-5 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Fujino T, Yamazaki Y, Largaespada DA, ''et al.'' |title=Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. |journal=Exp. Hematol. |volume=29 |issue= 7 |pages= 856-63 |year= 2001 |pmid= 11438208 |doi= }}
*{{cite journal | author=Knoepfler PS, Sykes DB, Pasillas M, Kamps MP |title=HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. |journal=Oncogene |volume=20 |issue= 39 |pages= 5440-8 |year= 2001 |pmid= 11571641 |doi= 10.1038/sj.onc.1204710 }}
*{{cite journal | author=Greer JM, Capecchi MR |title=Hoxb8 is required for normal grooming behavior in mice. |journal=Neuron |volume=33 |issue= 1 |pages= 23-34 |year= 2002 |pmid= 11779477 |doi= }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
{{Transcription factors|g3}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-17-stub}}

Latest revision as of 07:39, 19 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.[3]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results in a reduction of compulsive grooming.[4]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXB8 homeobox B8".
  4. ↑ Chen SK, Tvrdik P, Peden E, Cho S, Wu S, Spangrude G, Capecchi MR (May 2010). "Hematopoietic origin of pathological grooming in Hoxb8 mutant mice". Cell. 141 (5): 775–85. doi:10.1016/j.cell.2010.03.055. PMC 2894573. PMID 20510925.

Further reading

  • Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity. 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
  • Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
  • Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
  • Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
  • Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
  • Vider BZ, Zimber A, Hirsch D, Estlein D, Chastre E, Prevot S, Gespach C, Yaniv A, Gazit A (Mar 1997). "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression". Biochemical and Biophysical Research Communications. 232 (3): 742–8. doi:10.1006/bbrc.1997.6364. PMID 9126347.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T (Jul 2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
  • Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (Sep 2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene. 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.
  • Greer JM, Capecchi MR (Jan 2002). "Hoxb8 is required for normal grooming behavior in mice". Neuron. 33 (1): 23–34. doi:10.1016/S0896-6273(01)00564-5. PMID 11779477.
  • Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=HOXB8&oldid=1529227"