HOXA3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-A3''' is a [[protein]] that in humans is encoded by the ''HOXA3'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = July 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = November 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXA3 homeobox A3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3200| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox A3
| HGNCid = 5104
| Symbol = HOXA3
| AltSymbols =; HOX1; HOX1E; MGC10155
| OMIM = 142954
| ECnumber = 
| Homologene = 40725
| MGIid = 96175
| GeneAtlas_image1 = PBB_GE_HOXA3_208604_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001974 |text = blood vessel remodeling}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3200
    | Hs_Ensembl = ENSG00000105997
    | Hs_RefseqProtein = NP_109377
    | Hs_RefseqmRNA = NM_030661
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 27112334
    | Hs_GenLoc_end = 27133164
    | Hs_Uniprot = O43365
    | Mm_EntrezGene = 15400
    | Mm_Ensembl = ENSMUSG00000059723
    | Mm_RefseqmRNA = NM_010452
    | Mm_RefseqProtein = NP_034582
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 52098645
    | Mm_GenLoc_end = 52142919
    | Mm_Uniprot = P02831
  }}
}}
'''Homeobox A3''', also known as '''HOXA3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXA3 homeobox A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3200| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: HOXA3 homeobox A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3200| accessdate = }}</ref>
}}


==See also==
== Regulation ==
 
The HOXA3 gene is [[Gene regulation|repressed]] by the [[microRNA]] [[MicroRNA mir-10|miR-10a]].<ref name="pmid17660710">{{cite journal | vauthors = Han L, Witmer PD, Casey E, Valle D, Sukumar S | title = DNA methylation regulates MicroRNA expression | journal = Cancer Biology & Therapy | volume = 6 | issue = 8 | pages = 1284–8 | date = August 2007 | pmid = 17660710 }}</ref>
 
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenetics and Cell Genetics | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Manley NR, Capecchi MR | title = Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands | journal = Developmental Biology | volume = 195 | issue = 1 | pages = 1–15 | date = March 1998 | pmid = 9520319 | doi = 10.1006/dbio.1997.8827 }}
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–108 | date = November 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
*{{cite journal  | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Mulder GB, Manley N, Maggio-Price L | title = Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1 | journal = Teratology | volume = 58 | issue = 6 | pages = 263–75 | date = December 1998 | pmid = 9894676 | doi = 10.1002/(SICI)1096-9926(199812)58:6<263::AID-TERA8>3.0.CO;2-A }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Manzanares M, Nardelli J, Gilardi-Hebenstreit P, Marshall H, Giudicelli F, Martínez-Pastor MT, Krumlauf R, Charnay P | title = Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain | journal = The EMBO Journal | volume = 21 | issue = 3 | pages = 365–76 | date = February 2002 | pmid = 11823429 | pmc = 125344 | doi = 10.1093/emboj/21.3.365 }}
*{{cite journal | author=Manley NR, Capecchi MR |title=Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. |journal=Dev. Biol. |volume=195 |issue= 1 |pages= 1-15 |year= 1998 |pmid= 9520319 |doi= 10.1006/dbio.1997.8827 }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = February 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi= }}
* {{cite journal | vauthors = Kim J, Bhinge AA, Morgan XC, Iyer VR | title = Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment | journal = Nature Methods | volume = 2 | issue = 1 | pages = 47–53 | date = January 2005 | pmid = 15782160 | doi = 10.1038/nmeth726 }}
*{{cite journal | author=Mulder GB, Manley N, Maggio-Price L |title=Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. |journal=Teratology |volume=58 |issue= 6 |pages= 263-75 |year= 1999 |pmid= 9894676 |doi= 10.1002/(SICI)1096-9926(199812)58:6<263::AID-TERA8>3.0.CO;2-A }}
* {{cite journal | vauthors = Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M | title = The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors | journal = Nucleic Acids Research | volume = 34 | issue = 6 | pages = 1735–44 | year = 2006 | pmid = 16582099 | pmc = 1421504 | doi = 10.1093/nar/gkl105 }}
*{{cite journal | author=Manzanares M, Nardelli J, Gilardi-Hebenstreit P, ''et al.'' |title=Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. |journal=EMBO J. |volume=21 |issue= 3 |pages= 365-76 |year= 2002 |pmid= 11823429 |doi= 10.1093/emboj/21.3.365 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kim J, Bhinge AA, Morgan XC, Iyer VR |title=Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. |journal=Nat. Methods |volume=2 |issue= 1 |pages= 47-53 |year= 2005 |pmid= 15782160 |doi= 10.1038/nmeth726 }}
*{{cite journal | author=Wissmüller S, Kosian T, Wolf M, ''et al.'' |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735-44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-7-stub}}

Revision as of 14:00, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[1][2][3]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[3]

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a.[4]

See also

References

  1. ↑ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXA3 homeobox A3".
  4. ↑ Han L, Witmer PD, Casey E, Valle D, Sukumar S (August 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. PMID 17660710.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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