HOPX

Homeodomain-only protein
PDB rendering based on 2hi3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2hi3​
Identifiers
Symbols	HOP ; Cameo; LAGY; MGC20820; NECC1; OB1; SMAP31; Toto
External IDs	Template:OMIM5 Template:MGI HomoloGene: 15859
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Homeodomain-only protein, also known as HOP, is a human gene.

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.

Further reading

• Kook H, Epstein JA (2004). "Hopping to the beat. Hop regulation of cardiac gene expression". Trends Cardiovasc. Med. 13 (7): 261–4. PMID 14522464.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Chen F, Kook H, Milewski R; et al. (2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell. 110 (6): 713–23. PMID 12297045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asanoma K, Matsuda T, Kondo H; et al. (2003). "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics. 81 (1): 15–25. PMID 12573257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Y, Petersen S, Pacyna-Gengelbach M; et al. (2003). "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer". Oncology. 64 (4): 450–8. doi:10.1159/000070306. PMID 12759545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kook H, Lepore JJ, Gitler AD; et al. (2003). "Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop". J. Clin. Invest. 112 (6): 863–71. doi:10.1172/JCI200319137. PMID 12975471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adu J, Leong FT, Smith NR; et al. "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development". Mech. Dev. 119 Suppl 1: S43–7. PMID 14516659.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemaire F, Millon R, Muller D; et al. (2004). "Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma". Br. J. Cancer. 91 (2): 258–61. doi:10.1038/sj.bjc.6601952. PMID 15213722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C (2005). "A novel homeobox gene overexpressed in thyroid carcinoma". Thyroid. 14 (7): 500–5. doi:10.1089/1050725041517020. PMID 15307938.CS1 maint: Multiple names: authors list (link)
• Toruner GA, Ulger C, Alkan M; et al. (2004). "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma". Cancer Genet. Cytogenet. 154 (1): 27–35. doi:10.1016/j.cancergencyto.2004.01.026. PMID 15381369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asanoma K, Kato H, Inoue T; et al. (2004). "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The Journal of reproductive medicine. 49 (8): 617–26. PMID 15457851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kook H, Yung WW, Simpson RJ; et al. (2006). "Analysis of the structure and function of the transcriptional coregulator HOP". Biochemistry. 45 (35): 10584–90. doi:10.1021/bi060641s. PMID 16939210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kee HJ, Kim JR, Nam KI; et al. (2007). "Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation". J. Biol. Chem. 282 (10): 7700–9. doi:10.1074/jbc.M611198200. PMID 17192267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Americo TA, Chiarini LB, Linden R (2007). "Signaling induced by hop/STI-1 depends on endocytosis". Biochem. Biophys. Res. Commun. 358 (2): 620–5. doi:10.1016/j.bbrc.2007.04.202. PMID 17498662.CS1 maint: Multiple names: authors list (link)

External links

• HOPX+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.