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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeodomain-only protein''' is a [[protein]] that in humans is encoded by the ''HOPX'' [[gene]].<ref name="pmid12297045">{{cite journal | vauthors = Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA | title = Hop is an unusual homeobox gene that modulates cardiac development | journal = Cell | volume = 110 | issue = 6 | pages = 713–23 | date = September 2002 | pmid = 12297045 | pmc =  | doi = 10.1016/S0092-8674(02)00932-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOP homeodomain-only protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84525| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HOP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hi3.
| PDB = {{PDB2|2hi3}}
| Name = Homeodomain-only protein
| HGNCid = 
| Symbol = HOP
| AltSymbols =; Cameo; LAGY; MGC20820; NECC1; OB1; SMAP31; Toto
| OMIM = 607275
| ECnumber = 
| Homologene = 15859
| MGIid = 1916782
| GeneAtlas_image1 = PBB_GE_HOP_211597_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84525
    | Hs_Ensembl = ENSG00000171476
    | Hs_RefseqProtein = NP_115884
    | Hs_RefseqmRNA = NM_032495
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 57208921
    | Hs_GenLoc_end = 57242627
    | Hs_Uniprot = Q9BPY8
    | Mm_EntrezGene = 74318
    | Mm_Ensembl = ENSMUSG00000059325
    | Mm_RefseqmRNA = NM_175606
    | Mm_RefseqProtein = NP_783199
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 78161763
    | Mm_GenLoc_end = 78189898
    | Mm_Uniprot = Q8R1H0
  }}
}}
'''Homeodomain-only protein''', also known as '''HOP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOP homeodomain-only protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84525| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a [[Homeodomain|homeodomain]] protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HOP homeodomain-only protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84525| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kook H, Epstein JA | title = Hopping to the beat. Hop regulation of cardiac gene expression | journal = Trends in Cardiovascular Medicine | volume = 13 | issue = 7 | pages = 261–4 | date = October 2003 | pmid = 14522464 | doi = 10.1016/S1050-1738(03)00107-5 }}
| citations =
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Kook H, Epstein JA |title=Hopping to the beat. Hop regulation of cardiac gene expression. |journal=Trends Cardiovasc. Med. |volume=13 |issue= 7 |pages= 261-4 |year= 2004 |pmid= 14522464 |doi= }}
* {{cite journal | vauthors = Asanoma K, Matsuda T, Kondo H, Kato K, Kishino T, Niikawa N, Wake N, Kato H | title = NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif | journal = Genomics | volume = 81 | issue = 1 | pages = 15–25 | date = January 2003 | pmid = 12573257 | doi = 10.1016/S0888-7543(02)00011-3 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
* {{cite journal | vauthors = Chen Y, Petersen S, Pacyna-Gengelbach M, Pietas A, Petersen I | title = Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer | journal = Oncology | volume = 64 | issue = 4 | pages = 450–8 | year = 2003 | pmid = 12759545 | doi = 10.1159/000070306 }}
*{{cite journal  | author=Chen F, Kook H, Milewski R, ''et al.'' |title=Hop is an unusual homeobox gene that modulates cardiac development. |journal=Cell |volume=110 |issue= 6 |pages= 713-23 |year= 2002 |pmid= 12297045 |doi=  }}
* {{cite journal | vauthors = Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA | title = Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop | journal = The Journal of Clinical Investigation | volume = 112 | issue = 6 | pages = 863–71 | date = September 2003 | pmid = 12975471 | pmc = 193673 | doi = 10.1172/JCI19137 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Adu J, Leong FT, Smith NR, Leek JP, Markham AF, Robinson PA, Mighell AJ | title = Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development | journal = Mechanisms of Development | volume = 119 Suppl 1 | issue =  | pages = S43-7 | date = December 2002 | pmid = 14516659 | doi = 10.1016/S0925-4773(03)00090-X | series = 119 }}
*{{cite journal | author=Asanoma K, Matsuda T, Kondo H, ''et al.'' |title=NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. |journal=Genomics |volume=81 |issue= 1 |pages= 15-25 |year= 2003 |pmid= 12573257 |doi= }}
* {{cite journal | vauthors = Lemaire F, Millon R, Muller D, Rabouel Y, Bracco L, Abecassis J, Wasylyk B | title = Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma | journal = British Journal of Cancer | volume = 91 | issue = 2 | pages = 258–61 | date = July 2004 | pmid = 15213722 | pmc = 2409811 | doi = 10.1038/sj.bjc.6601952 }}
*{{cite journal | author=Chen Y, Petersen S, Pacyna-Gengelbach M, ''et al.'' |title=Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. |journal=Oncology |volume=64 |issue= 4 |pages= 450-8 |year= 2003 |pmid= 12759545 |doi= 10.1159/000070306 }}
* {{cite journal | vauthors = Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C | title = A novel homeobox gene overexpressed in thyroid carcinoma | journal = Thyroid | volume = 14 | issue = 7 | pages = 500–5 | date = July 2004 | pmid = 15307938 | doi = 10.1089/1050725041517020 }}
*{{cite journal | author=Kook H, Lepore JJ, Gitler AD, ''et al.'' |title=Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. |journal=J. Clin. Invest. |volume=112 |issue= 6 |pages= 863-71 |year= 2003 |pmid= 12975471 |doi= 10.1172/JCI200319137 }}
* {{cite journal | vauthors = Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ | title = Association between gene expression profile and tumor invasion in oral squamous cell carcinoma | journal = Cancer Genetics and Cytogenetics | volume = 154 | issue = 1 | pages = 27–35 | date = October 2004 | pmid = 15381369 | doi = 10.1016/j.cancergencyto.2004.01.026 }}
*{{cite journal | author=Adu J, Leong FT, Smith NR, ''et al.'' |title=Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development. |journal=Mech. Dev. |volume=119 Suppl 1 |issue=  |pages= S43-7 |year= |pmid= 14516659 |doi= }}
* {{cite journal | vauthors = Asanoma K, Kato H, Inoue T, Matsuda T, Wake N | title = Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts | journal = The Journal of Reproductive Medicine | volume = 49 | issue = 8 | pages = 617–26 | date = August 2004 | pmid = 15457851 | doi =  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Lemaire F, Millon R, Muller D, ''et al.'' |title=Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. |journal=Br. J. Cancer |volume=91 |issue= 2 |pages= 258-61 |year= 2004 |pmid= 15213722 |doi= 10.1038/sj.bjc.6601952 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal | author=Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C |title=A novel homeobox gene overexpressed in thyroid carcinoma. |journal=Thyroid |volume=14 |issue= 7 |pages= 500-5 |year= 2005 |pmid= 15307938 |doi= 10.1089/1050725041517020 }}
* {{cite journal | vauthors = Kook H, Yung WW, Simpson RJ, Kee HJ, Shin S, Lowry JA, Loughlin FE, Yin Z, Epstein JA, Mackay JP | title = Analysis of the structure and function of the transcriptional coregulator HOP | journal = Biochemistry | volume = 45 | issue = 35 | pages = 10584–90 | date = September 2006 | pmid = 16939210 | doi = 10.1021/bi060641s }}
*{{cite journal | author=Toruner GA, Ulger C, Alkan M, ''et al.'' |title=Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 27-35 |year= 2004 |pmid= 15381369 |doi= 10.1016/j.cancergencyto.2004.01.026 }}
* {{cite journal | vauthors = Kee HJ, Kim JR, Nam KI, Park HY, Shin S, Kim JC, Shimono Y, Takahashi M, Jeong MH, Kim N, Kim KK, Kook H | title = Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 10 | pages = 7700–9 | date = March 2007 | pmid = 17192267 | doi = 10.1074/jbc.M611198200 }}
*{{cite journal | author=Asanoma K, Kato H, Inoue T, ''et al.'' |title=Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. |journal=The Journal of reproductive medicine |volume=49 |issue= 8 |pages= 617-26 |year= 2004 |pmid= 15457851 |doi=  }}
* {{cite journal | vauthors = Americo TA, Chiarini LB, Linden R | title = Signaling induced by hop/STI-1 depends on endocytosis | journal = Biochemical and Biophysical Research Communications | volume = 358 | issue = 2 | pages = 620–5 | date = June 2007 | pmid = 17498662 | doi = 10.1016/j.bbrc.2007.04.202 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Kook H, Yung WW, Simpson RJ, ''et al.'' |title=Analysis of the structure and function of the transcriptional coregulator HOP. |journal=Biochemistry |volume=45 |issue= 35 |pages= 10584-90 |year= 2006 |pmid= 16939210 |doi= 10.1021/bi060641s }}
*{{cite journal | author=Kee HJ, Kim JR, Nam KI, ''et al.'' |title=Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. |journal=J. Biol. Chem. |volume=282 |issue= 10 |pages= 7700-9 |year= 2007 |pmid= 17192267 |doi= 10.1074/jbc.M611198200 }}
*{{cite journal | author=Americo TA, Chiarini LB, Linden R |title=Signaling induced by hop/STI-1 depends on endocytosis. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 2 |pages= 620-5 |year= 2007 |pmid= 17498662 |doi= 10.1016/j.bbrc.2007.04.202 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|HOPX+protein,+human}}
* {{MeshName|HOPX+protein,+human}}


{{PDB Gallery|geneid=84525}}
{{Transcription factors|g3}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-4-stub}}

Latest revision as of 12:04, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.[1][2]

Function

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[2]

References

  1. ↑ Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA (September 2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell. 110 (6): 713–23. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045.
  2. ↑ 2.0 2.1 "Entrez Gene: HOP homeodomain-only protein".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=HOPX&oldid=1526287"