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{{Infobox_gene}}
{{PBB_Controls
'''Hairy/enhancer-of-split related with YRPW motif protein 2''' (HEY2) also known as '''cardiovascular helix-loop-helix factor 1''' (CHF1) is a [[protein]] that in humans is encoded by the ''HEY2'' [[gene]].<ref name="pmid10415358">{{cite journal | vauthors = Leimeister C, Externbrink A, Klamt B, Gessler M | title = Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis | journal = Mech. Dev. | volume = 85 | issue = 1-2 | pages = 173–7  | date = Sep 1999 | pmid = 10415358 | pmc =  | doi = 10.1016/S0925-4773(99)00080-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23493| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Hairy/enhancer-of-split related with YRPW motif 2
| HGNCid = 4881
| Symbol = HEY2
| AltSymbols =; GRL; CHF1; HERP1; HESR2; HRT2; MGC10720
| OMIM = 604674
| ECnumber = 
| Homologene = 22705
| MGIid = 1341884
| GeneAtlas_image1 = PBB_GE_HEY2_219743_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23493
    | Hs_Ensembl = ENSG00000135547
    | Hs_RefseqProtein = NP_036391
    | Hs_RefseqmRNA = NM_012259
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 126110503
    | Hs_GenLoc_end = 126124108
    | Hs_Uniprot = Q9UBP5
    | Mm_EntrezGene = 15214
    | Mm_Ensembl = ENSMUSG00000019789
    | Mm_RefseqmRNA = NM_013904
    | Mm_RefseqProtein = NP_038932
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 30521775
    | Mm_GenLoc_end = 30532199
    | Mm_Uniprot = Q0VGJ1
  }}
}}
'''Hairy/enhancer-of-split related with YRPW motif 2''', also known as '''HEY2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23493| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
CHF1 is a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix ([[basic helix-loop-helix|bHLH]])-type [[transcription factor]]s. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a [[histone deacetylase]] complex to repress [[transcription (genetics)|transcription]]. Expression of this gene is induced by the [[Notch signaling pathway]]. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in [[neurogenesis]] and [[somitogenesis]]. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23493| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Common variants of [[SCN5A]], [[SCN10A]], and HEY2 (this gene) are associated with [[Brugada syndrome]].<ref name="Bezzina_Barc_2013">{{cite journal | vauthors = Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R | title = Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death | journal = Nat. Genet. | volume = 45 | issue = 9 | pages = 1044–9 | year = 2013 | pmid = 23872634 | pmc = 3869788 | doi = 10.1038/ng.2712 }}</ref>
 
== Interactions ==
 
HEY2 has been shown to [[Protein-protein interaction|interact]] with [[Sirtuin 1]]<ref name="pmid12535671">{{cite journal | vauthors = Takata T, Ishikawa F | title = Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression | journal = Biochem. Biophys. Res. Commun. | volume = 301 | issue = 1 | pages = 250–7  | date = January 2003 | pmid = 12535671 | doi = 10.1016/S0006-291X(02)03020-6 }}</ref> and [[Nuclear receptor co-repressor 1]].<ref name="pmid11486045">{{cite journal | vauthors = Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y | title = HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling | journal = Mol. Cell. Biol. | volume = 21 | issue = 17 | pages = 6080–9  | date = September 2001 | pmid = 11486045 | pmc = 87325 | doi = 10.1128/MCB.21.17.6080-6089.2001 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Iso T, Kedes L, Hamamori Y | title = HES and HERP families: multiple effectors of the Notch signaling pathway | journal = J. Cell. Physiol. | volume = 194 | issue = 3 | pages = 237–55 | year = 2003 | pmid = 12548545 | doi = 10.1002/jcp.10208 }}
| citations =
* {{cite journal | vauthors = Kokubo H, Miyagawa-Tomita S, Johnson RL | title = Hesr, a mediator of the Notch signaling, functions in heart and vessel development | journal = Trends Cardiovasc. Med. | volume = 15 | issue = 5 | pages = 190–4 | year = 2005 | pmid = 16165016 | doi = 10.1016/j.tcm.2005.05.005 }}
*{{cite journal | author=Iso T, Kedes L, Hamamori Y |title=HES and HERP families: multiple effectors of the Notch signaling pathway. |journal=J. Cell. Physiol. |volume=194 |issue= 3 |pages= 237-55 |year= 2003 |pmid= 12548545 |doi= 10.1002/jcp.10208 }}
* {{cite journal | vauthors = Chin MT, Maemura K, Fukumoto S, Jain MK, Layne MD, Watanabe M, Hsieh CM, Lee ME | title = Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system | journal = J. Biol. Chem. | volume = 275 | issue = 9 | pages = 6381–7 | year = 2000 | pmid = 10692439 | doi = 10.1074/jbc.275.9.6381 }}
*{{cite journal | author=Kokubo H, Miyagawa-Tomita S, Johnson RL |title=Hesr, a mediator of the Notch signaling, functions in heart and vessel development. |journal=Trends Cardiovasc. Med. |volume=15 |issue= 5 |pages= 190-4 |year= 2006 |pmid= 16165016 |doi= 10.1016/j.tcm.2005.05.005 }}
* {{cite journal | vauthors = Zhong TP, Rosenberg M, Mohideen MA, Weinstein B, Fishman MC | title = gridlock, an HLH gene required for assembly of the aorta in zebrafish | journal = Science | volume = 287 | issue = 5459 | pages = 1820–4 | year = 2000 | pmid = 10710309 | doi = 10.1126/science.287.5459.1820 }}
*{{cite journal | author=Leimeister C, Externbrink A, Klamt B, Gessler M |title=Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. |journal=Mech. Dev. |volume=85 |issue= 1-2 |pages= 173-7 |year= 1999 |pmid= 10415358 |doi=  }}
* {{cite journal | vauthors = Steidl C, Leimeister C, Klamt B, Maier M, Nanda I, Dixon M, Clarke R, Schmid M, Gessler M | title = Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family | journal = Genomics | volume = 66 | issue = 2 | pages = 195–203 | year = 2000 | pmid = 10860664 | doi = 10.1006/geno.2000.6200 }}
*{{cite journal  | author=Chin MT, Maemura K, Fukumoto S, ''et al.'' |title=Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6381-7 |year= 2000 |pmid= 10692439 |doi= }}
* {{cite journal | vauthors = Firulli BA, Hadzic DB, McDaid JR, Firulli AB | title = The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33567–73 | year = 2000 | pmid = 10924525 | pmc = 2561327 | doi = 10.1074/jbc.M005888200 }}
*{{cite journal | author=Zhong TP, Rosenberg M, Mohideen MA, ''et al.'' |title=gridlock, an HLH gene required for assembly of the aorta in zebrafish. |journal=Science |volume=287 |issue= 5459 |pages= 1820-4 |year= 2000 |pmid= 10710309 |doi= }}
* {{cite journal | vauthors = Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN | title = Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 25 | pages = 13655–60 | year = 2000 | pmid = 11095750 | pmc = 17631 | doi = 10.1073/pnas.250485597 }}
*{{cite journal | author=Steidl C, Leimeister C, Klamt B, ''et al.'' |title=Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. |journal=Genomics |volume=66 |issue= 2 |pages= 195-203 |year= 2000 |pmid= 10860664 |doi= 10.1006/geno.2000.6200 }}
* {{cite journal | vauthors = Iso T, Sartorelli V, Chung G, Shichinohe T, Kedes L, Hamamori Y | title = HERP, a new primary target of Notch regulated by ligand binding | journal = Mol. Cell. Biol. | volume = 21 | issue = 17 | pages = 6071–9 | year = 2001 | pmid = 11486044 | pmc = 87324 | doi = 10.1128/MCB.21.17.6071-6079.2001 }}
*{{cite journal | author=Firulli BA, Hadzic DB, McDaid JR, Firulli AB |title=The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33567-73 |year= 2000 |pmid= 10924525 |doi= 10.1074/jbc.M005888200 }}
* {{cite journal | vauthors = Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y | title = HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling | journal = Mol. Cell. Biol. | volume = 21 | issue = 17 | pages = 6080–9 | year = 2001 | pmid = 11486045 | pmc = 87325 | doi = 10.1128/MCB.21.17.6080-6089.2001 }}
*{{cite journal | author=Nakagawa O, McFadden DG, Nakagawa M, ''et al.'' |title=Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13655-60 |year= 2001 |pmid= 11095750 |doi= 10.1073/pnas.250485597 }}
* {{cite journal | vauthors = Takata T, Ishikawa F | title = Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression | journal = Biochem. Biophys. Res. Commun. | volume = 301 | issue = 1 | pages = 250–7 | year = 2003 | pmid = 12535671 | doi = 10.1016/S0006-291X(02)03020-6 }}
*{{cite journal | author=Iso T, Sartorelli V, Chung G, ''et al.'' |title=HERP, a new primary target of Notch regulated by ligand binding. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6071-9 |year= 2001 |pmid= 11486044 |doi= }}
* {{cite journal | vauthors = Fischer A, Klamt B, Schumacher N, Glaeser C, Hansmann I, Fenge H, Gessler M | title = Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome | journal = Mamm. Genome | volume = 15 | issue = 9 | pages = 711–6 | year = 2004 | pmid = 15389319 | doi = 10.1007/s00335-004-2389-x }}
*{{cite journal | author=Iso T, Sartorelli V, Poizat C, ''et al.'' |title=HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 6080-9 |year= 2001 |pmid= 11486045 |doi= }}
* {{cite journal | vauthors = Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson RL | title = Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system | journal = Dev. Biol. | volume = 278 | issue = 2 | pages = 301–9 | year = 2005 | pmid = 15680351 | doi = 10.1016/j.ydbio.2004.10.025 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, Kawai-Kowase K, Tanaka T, Maeno T, Okamoto E, Arai M, Kedes L, Kurabayashi M | title = HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box | journal = Arterioscler. Thromb. Vasc. Biol. | volume = 25 | issue = 11 | pages = 2328–34 | year = 2005 | pmid = 16151017 | doi = 10.1161/01.ATV.0000185829.47163.32 }}
*{{cite journal | author=Takata T, Ishikawa F |title=Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 1 |pages= 250-7 |year= 2003 |pmid= 12535671 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Fischer A, Klamt B, Schumacher N, ''et al.'' |title=Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. |journal=Mamm. Genome |volume=15 |issue= 9 |pages= 711-6 |year= 2005 |pmid= 15389319 |doi= 10.1007/s00335-004-2389-x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kokubo H, Miyagawa-Tomita S, Nakazawa M, ''et al.'' |title=Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. |journal=Dev. Biol. |volume=278 |issue= 2 |pages= 301-9 |year= 2005 |pmid= 15680351 |doi= 10.1016/j.ydbio.2004.10.025 }}
*{{cite journal | author=Doi H, Iso T, Yamazaki M, ''et al.'' |title=HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 11 |pages= 2328-34 |year= 2006 |pmid= 16151017 |doi= 10.1161/01.ATV.0000185829.47163.32 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|HEY2+protein,+human}}
* {{MeshName|HEY2+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-6-stub}}

Latest revision as of 02:07, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene.[1][2]

Function

CHF1 is a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signaling pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.[2]

Clinical significance

Common variants of SCN5A, SCN10A, and HEY2 (this gene) are associated with Brugada syndrome.[3]

Interactions

HEY2 has been shown to interact with Sirtuin 1[4] and Nuclear receptor co-repressor 1.[5]

References

  1. ↑ Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech. Dev. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358.
  2. ↑ 2.0 2.1 "Entrez Gene: HEY2 hairy/enhancer-of-split related with YRPW motif 2".
  3. ↑ Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R (2013). "Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death". Nat. Genet. 45 (9): 1044–9. doi:10.1038/ng.2712. PMC 3869788. PMID 23872634.
  4. ↑ Takata T, Ishikawa F (January 2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. 301 (1): 250–7. doi:10.1016/S0006-291X(02)03020-6. PMID 12535671.
  5. ↑ Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y (September 2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. 21 (17): 6080–9. doi:10.1128/MCB.21.17.6080-6089.2001. PMC 87325. PMID 11486045.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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