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{{Infobox_gene}}
{{PBB_Controls
'''Glucocorticoid receptor DNA-binding factor 1''' is a [[protein]] that in humans is encoded by the ''GRLF1'' [[gene]].<ref name="pmid1894621">{{cite journal | vauthors = LeClerc S, Palaniswami R, Xie BX, Govindan MV | title = Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression | journal = The Journal of Biological Chemistry | volume = 266 | issue = 26 | pages = 17333–40 | date = Sep 1991 | pmid = 1894621 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2909| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glucocorticoid receptor DNA binding factor 1
| HGNCid = 4591
| Symbol = GRLF1
| AltSymbols =; GRF-1; KIAA1722; MGC10745; P190-A; P190A; p190RhoGAP
| OMIM = 605277
| ECnumber = 
| Homologene = 35136
| MGIid = 1929494
| GeneAtlas_image1 = PBB_GE_GRLF1_202046_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRLF1_202044_at_tn.png
| GeneAtlas_image3 = PBB_GE_GRLF1_gnf1h03426_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0001843 |text = neural tube closure}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0042478 |text = regulation of eye photoreceptor cell development}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2909
    | Hs_Ensembl = ENSG00000160007
    | Hs_RefseqProtein = NP_004482
    | Hs_RefseqmRNA = NM_004491
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 52113773
    | Hs_GenLoc_end = 52196472
    | Hs_Uniprot = Q9NRY4
    | Mm_EntrezGene = 232906
    | Mm_Ensembl = ENSMUSG00000058230
    | Mm_RefseqmRNA = NM_172739
    | Mm_RefseqProtein = NP_766327
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 15653561
    | Mm_GenLoc_end = 15773515
    | Mm_Uniprot = Q3TSU7
  }}
}}
'''Glucocorticoid receptor DNA binding factor 1''', also known as '''GRLF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2909| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.<ref name="entrez">{{cite web | title = Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2909| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|33em}}
| citations =
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Warriar N, Pagé N, Govindan MV | title = Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element | journal = The Journal of Biological Chemistry | volume = 271 | issue = 31 | pages = 18662–71 | date = Aug 1996 | pmid = 8702520 | doi = 10.1074/jbc.271.31.18662 }}
*{{cite journal  | author=LeClerc S, Palaniswami R, Xie BX, Govindan MV |title=Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression. |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17333-40 |year= 1991 |pmid= 1894621 |doi=  }}
* {{cite journal | vauthors = Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H | title = p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas | journal = Gene | volume = 257 | issue = 1 | pages = 23–31 | date = Oct 2000 | pmid = 11054565 | doi = 10.1016/S0378-1119(00)00387-5 }}
*{{cite journal | author=Warriar N, Pagé N, Govindan MV |title=Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18662-71 |year= 1996 |pmid= 8702520 |doi= }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 6 | pages = 347–55 | date = Dec 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 }}
*{{cite journal | author=Tikoo A, Czekay S, Viars C, ''et al.'' |title=p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. |journal=Gene |volume=257 |issue= 1 |pages= 23-31 |year= 2001 |pmid= 11054565 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi=  }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = Jan 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L | title = p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling | journal = Journal of Cell Science | volume = 118 | issue = Pt 20 | pages = 4689–700 | date = Oct 2005 | pmid = 16188938 | doi = 10.1242/jcs.02590 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D | title = Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability | journal = The Journal of Biological Chemistry | volume = 281 | issue = 4 | pages = 2296–305 | date = Jan 2006 | pmid = 16308318 | doi = 10.1074/jbc.M511248200 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Barberis D, Casazza A, Sordella R, ''et al.'' |title=p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling. |journal=J. Cell. Sci. |volume=118 |issue= Pt 20 |pages= 4689-700 |year= 2006 |pmid= 16188938 |doi= 10.1242/jcs.02590 }}
* {{cite journal | vauthors = Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP | title = Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo | journal = The Journal of Biological Chemistry | volume = 282 | issue = 33 | pages = 23910–8 | date = Aug 2007 | pmid = 17562701 | doi = 10.1074/jbc.M702169200 }}
*{{cite journal | author=Holinstat M, Knezevic N, Broman M, ''et al.'' |title=Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. |journal=J. Biol. Chem. |volume=281 |issue= 4 |pages= 2296-305 |year= 2006 |pmid= 16308318 |doi= 10.1074/jbc.M511248200 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Mammoto T, Parikh SM, Mammoto A, ''et al.'' |title=Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. |journal=J. Biol. Chem. |volume=282 |issue= 33 |pages= 23910-8 |year= 2007 |pmid= 17562701 |doi= 10.1074/jbc.M702169200 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|GRLF1+protein,+human}}
* {{MeshName|GRLF1+protein,+human}}
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00002004 GRLF1] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]


 
{{gene-19-stub}}
{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors|g2}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 02:34, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.[1][2]

Function

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.[2]

References

  1. ↑ LeClerc S, Palaniswami R, Xie BX, Govindan MV (Sep 1991). "Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression". The Journal of Biological Chemistry. 266 (26): 17333–40. PMID 1894621.
  2. ↑ 2.0 2.1 "Entrez Gene: GRLF1 glucocorticoid receptor DNA binding factor 1".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Warriar N, Pagé N, Govindan MV (Aug 1996). "Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element". The Journal of Biological Chemistry. 271 (31): 18662–71. doi:10.1074/jbc.271.31.18662. PMID 8702520.
  • Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H (Oct 2000). "p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas". Gene. 257 (1): 23–31. doi:10.1016/S0378-1119(00)00387-5. PMID 11054565.
  • Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (Jan 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L (Oct 2005). "p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling". Journal of Cell Science. 118 (Pt 20): 4689–700. doi:10.1242/jcs.02590. PMID 16188938.
  • Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D (Jan 2006). "Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability". The Journal of Biological Chemistry. 281 (4): 2296–305. doi:10.1074/jbc.M511248200. PMID 16308318.
  • Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo". The Journal of Biological Chemistry. 282 (33): 23910–8. doi:10.1074/jbc.M702169200. PMID 17562701.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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