GATA2

GATA binding protein 2
PDB rendering based on 1gnf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gnf​, 1y0j​
Identifiers
Symbols	GATA2 ; MGC2306; NFE1B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32030
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GATA binding protein 2, also known as GATA2, is a human gene.

The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells (Tsai et al., 1994). GATA1 (MIM 305371) is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation (Briegel et al., 1993). GATA3 (MIM 131320) expression is restricted to T-lymphoid cells and some nonhematopoietic cell types, including embryonic stem cells.[supplied by OMIM]

See also

• GATA transcription factor

Further reading

• Minegishi N (2002). "[Transcription factors regulating hematopoiesis: researches spanning from molecule to whole body]". Seikagaku. 74 (5): 398–402. PMID 12073612.
• Ohneda K, Yamamoto M (2003). "Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage". Acta Haematol. 108 (4): 237–45. PMID 12432220.
• Dorfman DM, Wilson DB, Bruns GA, Orkin SH (1992). "Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells". J. Biol. Chem. 267 (2): 1279–85. PMID 1370462.CS1 maint: Multiple names: authors list (link)
• Page RL, Wharton JM, Wilkinson WE; et al. (1992). "Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics". Clin. Pharmacol. Ther. 51 (4): 371–8. PMID 1563207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee ME, Temizer DH, Clifford JA, Quertermous T (1991). "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells". J. Biol. Chem. 266 (24): 16188–92. PMID 1714909.CS1 maint: Multiple names: authors list (link)
• Zhang R, Min W, Sessa WC (1995). "Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells". J. Biol. Chem. 270 (25): 15320–6. PMID 7541039.CS1 maint: Multiple names: authors list (link)
• Osada H, Grutz G, Axelson H; et al. (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. PMID 7568177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Towatari M, May GE, Marais R; et al. (1995). "Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3". J. Biol. Chem. 270 (8): 4101–7. PMID 7876160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai FY, Keller G, Kuo FC; et al. (1994). "An early haematopoietic defect in mice lacking the transcription factor GATA-2". Nature. 371 (6494): 221–6. doi:10.1038/371221a0. PMID 8078582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Briegel K, Lim KC, Plank C; et al. (1993). "Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner". Genes Dev. 7 (6): 1097–109. PMID 8504932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Towatari M, Kanei Y, Saito H, Hamaguchi M (1998). "Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 long terminal repeat". AIDS. 12 (3): 253–9. PMID 9517987.CS1 maint: Multiple names: authors list (link)
• Dasen JS, O'Connell SM, Flynn SE; et al. (1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. PMID 10367888.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang P, Behre G, Pan J; et al. (1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–10. PMID 10411939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wieser R, Volz A, Vinatzer U; et al. (2000). "Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia". Biochem. Biophys. Res. Commun. 273 (1): 239–45. doi:10.1006/bbrc.2000.2947. PMID 10873593.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuzuki S, Towatari M, Saito H, Enver T (2000). "Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein". Mol. Cell. Biol. 20 (17): 6276–86. PMID 10938104.CS1 maint: Multiple names: authors list (link)
• Yamashita K, Discher DJ, Hu J; et al. (2001). "Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP". J. Biol. Chem. 276 (16): 12645–53. doi:10.1074/jbc.M011344200. PMID 11278891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ozawa Y, Towatari M, Tsuzuki S; et al. (2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116–23. PMID 11567998.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang SB, He QY, Zhao H; et al. (2002). "Function of GATA transcription factors in hydroxyurea-induced HEL cells". Cell Res. 11 (4): 301–10. doi:10.1038/sj.cr.7290100. PMID 11787775.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuzuki S, Enver T (2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood. 99 (9): 3404–10. PMID 11964310.
• Hirasawa R, Shimizu R, Takahashi S; et al. (2002). "Essential and instructive roles of GATA factors in eosinophil development". J. Exp. Med. 195 (11): 1379–86. PMID 12045236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GATA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.