FOXN3: Difference between revisions

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Latest revision as of 04:54, 31 August 2017

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.^[1]^[2]

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.^[2]

References

↑ Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. PMC 232156. PMID 9154802.
↑ ^2.0 ^2.1 "Entrez Gene: CHES1 checkpoint suppressor 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Field LL, Tobias R, Thomson G, Plon S (1996). "Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31". Genomics. 33 (1): 1–8. doi:10.1006/geno.1996.0153. PMID 8617492.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Scott KL, Plon SE (2005). "CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor". Gene. 359: 119–26. doi:10.1016/j.gene.2005.06.014. PMID 16102918.
Busygina V, Kottemann MC, Scott KL, et al. (2007). "Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response". Cancer Res. 66 (17): 8397–403. doi:10.1158/0008-5472.CAN-06-0061. PMID 16951149.
Katoh H, Ojima H, Kokubu A, et al. (2007). "Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets". Gastroenterology. 133 (5): 1475–86. doi:10.1053/j.gastro.2007.08.038. PMID 17983802.

External links

CHES1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[pmid9154802-1] Pati D, Keller C, Groudine M, Plon SE (Jun 1997). "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA". Mol Cell Biol. 17 (6): 3037–46. PMC 232156. PMID 9154802.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CHES1 checkpoint suppressor 1".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Forkhead box protein N3''' is a [[protein]] that in humans is encoded by the ''FOXN3'' [[gene]].<ref name="pmid9154802">{{cite journal |vauthors=Pati D, Keller C, Groudine M, Plon SE | title = Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA | journal = Mol Cell Biol | volume = 17 | issue = 6 | pages = 3037–46 |date=Jun 1997 | pmid = 9154802 | pmc = 232156 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHES1 checkpoint suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1112| accessdate = }}</ref>
-| update_page = yes
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-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Checkpoint suppressor 1
- | HGNCid = 1928
- | Symbol = CHES1
- | AltSymbols =; C14orf116; FOXN3; PRO1635
- | OMIM = 602628
- | ECnumber =
- | Homologene = 3809
- | MGIid = 1918625
- | GeneAtlas_image1 = PBB_GE_CHES1_205022_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CHES1_205021_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_CHES1_218031_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0000077 |text = DNA damage checkpoint}} {{GNF_GO|id=GO:0000085 |text = G2 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1112
-    | Hs_Ensembl = ENSG00000053254
-    | Hs_RefseqProtein = NP_005188
-    | Hs_RefseqmRNA = NM_005197
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 88692282
-    | Hs_GenLoc_end = 88953127
-    | Hs_Uniprot = O00409
-    | Mm_EntrezGene = 71375
-    | Mm_Ensembl = ENSMUSG00000033713
-    | Mm_RefseqmRNA = NM_183186
-    | Mm_RefseqProtein = NP_899009
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 12
-    | Mm_GenLoc_start = 99596053
-    | Mm_GenLoc_end = 99851124
-    | Mm_Uniprot = Q499D0
-  }}
-}}
-'''Checkpoint suppressor 1''', also known as '''CHES1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHES1 checkpoint suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1112| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: CHES1 checkpoint suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1112| accessdate = }}</ref>
+| summary_text = This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.<ref name="entrez" />
 }}
@@ Line 60: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 66: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Field LL, Tobias R, Thomson G, Plon S |title=Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. |journal=Genomics |volume=33 |issue= 1 |pages= 1-8 |year= 1996 |pmid= 8617492 |doi= 10.1006/geno.1996.0153 }}
+*{{cite journal  |vauthors=Field LL, Tobias R, Thomson G, Plon S |title=Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. |journal=Genomics |volume=33 |issue= 1 |pages= 1–8 |year= 1996 |pmid= 8617492 |doi= 10.1006/geno.1996.0153 }}
-*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
+*{{cite journal  |vauthors=Hillier LD, Lennon G, Becker M |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  |display-authors=etal}}
-*{{cite journal  | author=Pati D, Keller C, Groudine M, Plon SE |title=Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3037-46 |year= 1997 |pmid= 9154802 |doi=  }}
+*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  |vauthors=Yu Y, Zhang C, Zhou G |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501  | pmc=311073 |display-authors=etal}}
-*{{cite journal  | author=Yu Y, Zhang C, Zhou G, ''et al.'' |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392-403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Heilig R, Eckenberg R, Petit JL |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 |display-authors=etal}}
-*{{cite journal  | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
+*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
-*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
+*{{cite journal  |vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316 |display-authors=etal}}
-*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Scott KL, Plon SE |title=CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. |journal=Gene |volume=359 |issue=  |pages= 119–26 |year= 2005 |pmid= 16102918 |doi= 10.1016/j.gene.2005.06.014 }}
-*{{cite journal  | author=Scott KL, Plon SE |title=CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. |journal=Gene |volume=359 |issue=  |pages= 119-26 |year= 2005 |pmid= 16102918 |doi= 10.1016/j.gene.2005.06.014 }}
+*{{cite journal  |vauthors=Busygina V, Kottemann MC, Scott KL |title=Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8397–403 |year= 2007 |pmid= 16951149 |doi= 10.1158/0008-5472.CAN-06-0061 |display-authors=etal}}
-*{{cite journal  | author=Busygina V, Kottemann MC, Scott KL, ''et al.'' |title=Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8397-403 |year= 2007 |pmid= 16951149 |doi= 10.1158/0008-5472.CAN-06-0061 }}
+*{{cite journal  |vauthors=Katoh H, Ojima H, Kokubu A |title=Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. |journal=Gastroenterology |volume=133 |issue= 5 |pages= 1475–86 |year= 2007 |pmid= 17983802 |doi= 10.1053/j.gastro.2007.08.038 |display-authors=etal}}
-*{{cite journal  | author=Katoh H, Ojima H, Kokubu A, ''et al.'' |title=Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. |journal=Gastroenterology |volume=133 |issue= 5 |pages= 1475-86 |year= 2007 |pmid= 17983802 |doi= 10.1053/j.gastro.2007.08.038 }}
 }}
 {{refend}}
@@ Line 87: / Line 38: @@
 * {{MeshName|CHES1+protein,+human}}
-{{protein-stub}}
 {{Transcription factors}}
-[[Category:Transcription factors]]
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:Forkhead transcription factors]]
+{{gene-14-stub}}

FOXN3: Difference between revisions

Latest revision as of 04:54, 31 August 2017

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References

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