FOXH1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Forkhead box protein H1''' is a [[protein]] that in humans is encoded by the ''FOXH1'' [[gene]].<ref name="pmid9702198">{{cite journal | vauthors = Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B | title = Characterization of human FAST-1, a TGF beta and activin signal transducer | journal = Mol Cell | volume = 2 | issue = 1 | pages = 121–7 | date = August 1998 | pmid = 9702198 | pmc =  | doi = 10.1016/S1097-2765(00)80120-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOXH1 forkhead box H1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Forkhead box H1
| HGNCid = 3814
| Symbol = FOXH1
| AltSymbols =; FAST-1; FAST1
| OMIM = 603621
| ECnumber = 
| Homologene = 2914
| MGIid = 1347465
| GeneAtlas_image1 = PBB_GE_FOXH1_207644_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0032444 |text = activin responsive factor complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0035054 |text = embryonic heart tube anterior/posterior pattern formation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048318 |text = axial mesoderm development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8928
    | Hs_Ensembl = ENSG00000160973
    | Hs_RefseqProtein = NP_003914
    | Hs_RefseqmRNA = NM_003923
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 145670429
    | Hs_GenLoc_end = 145672526
    | Hs_Uniprot = O75593
    | Mm_EntrezGene = 14106
    | Mm_Ensembl = ENSMUSG00000033837
    | Mm_RefseqmRNA = NM_007989
    | Mm_RefseqProtein = NP_032015
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 76495480
    | Mm_GenLoc_end = 76497126
    | Mm_Uniprot = Q0VEP8
  }}
}}
'''Forkhead box H1''', also known as '''FOXH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOXH1 forkhead box H1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.<ref name="entrez">{{cite web | title = Entrez Gene: FOXH1 forkhead box H1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
FOXH1 has been shown to [[Protein-protein interaction|interact]] with [[DRAP1]]<ref name=pmid12471260>{{cite journal | vauthors = Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM | title = Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1 | journal = [[Science (journal)|Science]] | volume = 298 | issue = 5600 | pages = 1996–9 | date = December 2002 | pmid = 12471260 | doi = 10.1126/science.1073405 }}</ref> and [[Mothers against decapentaplegic homolog 2]].<ref name=pmid10199400>{{cite journal | vauthors = Wotton D, Lo RS, Lee S, Massagué J | title = A Smad transcriptional corepressor | journal = Cell | volume = 97 | issue = 1 | pages = 29–39 | date = April 1999 | pmid = 10199400 | doi = 10.1016/S0092-8674(00)80712-6 }}</ref><ref name=pmid9858566>{{cite journal | vauthors = Liu B, Dou CL, Prabhu L, Lai E | title = FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals | journal = Mol. Cell. Biol. | volume = 19 | issue = 1 | pages = 424–30 | date = January 1999 | pmid = 9858566 | pmc = 83900 }}</ref><ref name=pmid9389648>{{cite journal | vauthors = Liu F, Pouponnot C, Massagué J | title = Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes | journal = Genes Dev. | volume = 11 | issue = 23 | pages = 3157–67 | date = December 1997 | pmid = 9389648 | pmc = 316747 | doi = 10.1101/gad.11.23.3157 }}</ref><ref name=pmid10938097>{{cite journal | vauthors = Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E | title = BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6201–11 | date = September 2000 | pmid = 10938097 | pmc = 86095 | doi = 10.1128/MCB.20.17.6201-6211.2000 }}</ref><ref name=pmid9288972>{{cite journal | vauthors = Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M | title = Smad4 and FAST-1 in the assembly of activin-responsive factor | journal = [[Nature (journal)|Nature]] | volume = 389 | issue = 6646 | pages = 85–9 | date = September 1997 | pmid = 9288972 | doi = 10.1038/38008 }}</ref>
 
== See also ==
* [[FOX proteins]]
* [[FOX proteins]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M | title = Smad4 and FAST-1 in the assembly of activin-responsive factor | journal = Nature | volume = 389 | issue = 6646 | pages = 85–9 | year = 1997 | pmid = 9288972 | doi = 10.1038/38008 }}
| citations =
* {{cite journal | vauthors = Liu F, Pouponnot C, Massagué J | title = Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes | journal = Genes Dev. | volume = 11 | issue = 23 | pages = 3157–67 | year = 1998 | pmid = 9389648 | pmc = 316747 | doi = 10.1101/gad.11.23.3157 }}
*{{cite journal | author=Chen X, Weisberg E, Fridmacher V, ''et al.'' |title=Smad4 and FAST-1 in the assembly of activin-responsive factor. |journal=Nature |volume=389 |issue= 6646 |pages= 85-9 |year= 1997 |pmid= 9288972 |doi= 10.1038/38008 }}
* {{cite journal | vauthors = Liu B, Dou CL, Prabhu L, Lai E | title = FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals | journal = Mol. Cell. Biol. | volume = 19 | issue = 1 | pages = 424–30 | year = 1999 | pmid = 9858566 | pmc = 83900 | doi =  }}
*{{cite journal | author=Liu F, Pouponnot C, Massagué J |title=Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. |journal=Genes Dev. |volume=11 |issue= 23 |pages= 3157-67 |year= 1998 |pmid= 9389648 |doi= }}
* {{cite journal | vauthors = Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E | title = BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6201–11 | year = 2000 | pmid = 10938097 | pmc = 86095 | doi = 10.1128/MCB.20.17.6201-6211.2000 }}
*{{cite journal  | author=Zhou S, Zawel L, Lengauer C, ''et al.'' |title=Characterization of human FAST-1, a TGF beta and activin signal transducer. |journal=Mol. Cell |volume=2 |issue= 1 |pages= 121-7 |year= 1998 |pmid= 9702198 |doi=  }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Liu B, Dou CL, Prabhu L, Lai E |title=FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 424-30 |year= 1999 |pmid= 9858566 |doi=  }}
* {{cite journal | vauthors = Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A | title = c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 11 | pages = 6198–203 | year = 2001 | pmid = 11371641 | pmc = 33445 | doi = 10.1073/pnas.101579798 }}
*{{cite journal | author=Dou C, Lee J, Liu B, ''et al.'' |title=BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6201-11 |year= 2000 |pmid= 10938097 |doi= }}
* {{cite journal | vauthors = Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM | title = Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1 | journal = Science | volume = 298 | issue = 5600 | pages = 1996–9 | year = 2003 | pmid = 12471260 | doi = 10.1126/science.1073405 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Seoane J, Le HV, Shen L, Anderson SA, Massagué J | title = Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation | journal = Cell | volume = 117 | issue = 2 | pages = 211–23 | year = 2004 | pmid = 15084259 | doi = 10.1016/S0092-8674(04)00298-3 }}
*{{cite journal | author=Pessah M, Prunier C, Marais J, ''et al.'' |title=c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 11 |pages= 6198-203 |year= 2001 |pmid= 11371641 |doi= 10.1073/pnas.101579798 }}
* {{cite journal | vauthors = von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL | title = Foxh1 is essential for development of the anterior heart field | journal = Dev. Cell | volume = 7 | issue = 3 | pages = 331–45 | year = 2004 | pmid = 15363409 | doi = 10.1016/j.devcel.2004.07.023 }}
*{{cite journal | author=Iratni R, Yan YT, Chen C, ''et al.'' |title=Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. |journal=Science |volume=298 |issue= 5600 |pages= 1996-9 |year= 2003 |pmid= 12471260 |doi= 10.1126/science.1073405 }}
* {{cite journal | vauthors = Kelemen SF, Eisen HJ, Autieri MV | title = Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells | journal = J. Heart Lung Transplant. | volume = 24 | issue = 3 | pages = 246–50 | year = 2005 | pmid = 15737749 | doi = 10.1016/j.healun.2004.01.015 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Cui Q, Lim SK, Zhao B, Hoffmann FM | title = Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP | journal = Oncogene | volume = 24 | issue = 24 | pages = 3864–74 | year = 2005 | pmid = 15750622 | doi = 10.1038/sj.onc.1208556 }}
*{{cite journal  | author=Seoane J, Le HV, Shen L, ''et al.'' |title=Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. |journal=Cell |volume=117 |issue= 2 |pages= 211-23 |year= 2004 |pmid= 15084259 |doi= }}
* {{cite journal | vauthors = Hart AH, Willson TA, Wong M, Parker K, Robb L | title = Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1 | journal = Biochem. Biophys. Res. Commun. | volume = 333 | issue = 4 | pages = 1361–9 | year = 2005 | pmid = 15982639 | doi = 10.1016/j.bbrc.2005.06.044 }}
*{{cite journal | author=von Both I, Silvestri C, Erdemir T, ''et al.'' |title=Foxh1 is essential for development of the anterior heart field. |journal=Dev. Cell |volume=7 |issue= 3 |pages= 331-45 |year= 2004 |pmid= 15363409 |doi= 10.1016/j.devcel.2004.07.023 }}
* {{cite journal | vauthors = Chen G, Nomura M, Morinaga H, Matsubara E, Okabe T, Goto K, Yanase T, Zheng H, Lu J, Nawata H | title = Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor | journal = J. Biol. Chem. | volume = 280 | issue = 43 | pages = 36355–63 | year = 2006 | pmid = 16120611 | doi = 10.1074/jbc.M506147200 }}
*{{cite journal | author=Kelemen SF, Eisen HJ, Autieri MV |title=Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells. |journal=J. Heart Lung Transplant. |volume=24 |issue= 3 |pages= 246-50 |year= 2005 |pmid= 15737749 |doi= 10.1016/j.healun.2004.01.015 }}
*{{cite journal | author=Cui Q, Lim SK, Zhao B, Hoffmann FM |title=Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP. |journal=Oncogene |volume=24 |issue= 24 |pages= 3864-74 |year= 2005 |pmid= 15750622 |doi= 10.1038/sj.onc.1208556 }}
*{{cite journal | author=Hart AH, Willson TA, Wong M, ''et al.'' |title=Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1. |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 4 |pages= 1361-9 |year= 2005 |pmid= 15982639 |doi= 10.1016/j.bbrc.2005.06.044 }}
*{{cite journal | author=Chen G, Nomura M, Morinaga H, ''et al.'' |title=Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36355-63 |year= 2006 |pmid= 16120611 |doi= 10.1074/jbc.M506147200 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
[[Category:Transcription factors]]
 
{{WikiDoc Sources}}
[[Category:Forkhead transcription factors]]
 
 
{{gene-8-stub}}

Latest revision as of 02:27, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]

Interactions

FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]

See also

References

  1. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell. 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.
  2. 2.0 2.1 "Entrez Gene: FOXH1 forkhead box H1".
  3. Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.
  4. Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400.
  5. Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566.
  6. Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
  7. Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
  8. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.