ETV4: Difference between revisions

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{{Infobox_gene}}
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'''ETS translocation variant 4''' ('''ETV4'''), also known as '''polyoma enhancer activator 3''' ('''PEA3'''), is a member of the [[PEA3|PEA3 subfamily]] of [[ETS transcription factor family|Ets transcription factors]].<ref name="pmid8530053">{{cite journal | vauthors = Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K | title = Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21 | journal = Genomics | volume = 28 | issue = 2 | pages = 357–9 | date = Jul 1995 | pmid = 8530053 | pmc =  | doi = 10.1006/geno.1995.1158 }}</ref><ref>{{cite web | title = Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2118| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Ets variant gene 4 (E1A enhancer binding protein, E1AF)
| HGNCid = 3493
| Symbol = ETV4
| AltSymbols =; E1A-F; E1AF; PEA3; PEAS3
| OMIM = 600711
| ECnumber = 
| Homologene = 1504
| MGIid = 99423
| GeneAtlas_image1 = PBB_GE_ETV4_211603_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008045 |text = motor axon guidance}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2118
    | Hs_Ensembl = ENSG00000175832
    | Hs_RefseqProtein = NP_001073143
    | Hs_RefseqmRNA = NM_001079675
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 38960738
    | Hs_GenLoc_end = 38979230
    | Hs_Uniprot = P43268
    | Mm_EntrezGene = 18612
    | Mm_Ensembl = ENSMUSG00000017724
    | Mm_RefseqmRNA = NM_008815
    | Mm_RefseqProtein = NP_032841
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 101585841
    | Mm_GenLoc_end = 101601353
    | Mm_Uniprot = Q3UMZ6
  }}
}}
'''Ets variant gene 4 (E1A enhancer binding protein, E1AF)''', also known as '''ETV4''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2118| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
 
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE | title = 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors | journal = Genomics | volume = 25 | issue = 1 | pages = 256–63 | date = Jan 1995 | pmid = 7774926 | doi = 10.1016/0888-7543(95)80133-7 }}
| citations =
* {{cite journal | vauthors = Liu SH, Peng BH, Ma JT, Liu YC, Ng SY | title = Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor | journal = Developmental Genetics | volume = 16 | issue = 3 | pages = 229–40 | year = 1995 | pmid = 7796532 | doi = 10.1002/dvg.1020160303 }}
*{{cite journal | author=Friedman LS, Ostermeyer EA, Lynch ED, ''et al.'' |title=22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. |journal=Genomics |volume=25 |issue= 1 |pages= 256-63 |year= 1995 |pmid= 7774926 |doi= }}
* {{cite journal | vauthors = Friedman LS, Ostermeyer EA, Lynch ED, Szabo CI, Anderson LA, Dowd P, Lee MK, Rowell SE, Boyd J, King MC | title = The search for BRCA1 | journal = Cancer Research | volume = 54 | issue = 24 | pages = 6374–82 | date = Dec 1994 | pmid = 7987831 | doi =  }}
*{{cite journal | author=Liu SH, Peng BH, Ma JT, ''et al.'' |title=Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor. |journal=Dev. Genet. |volume=16 |issue= 3 |pages= 229-40 |year= 1995 |pmid= 7796532 |doi= 10.1002/dvg.1020160303 }}
* {{cite journal | vauthors = Higashino F, Yoshida K, Fujinaga Y, Kamio K, Fujinaga K | title = Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family | journal = Nucleic Acids Research | volume = 21 | issue = 3 | pages = 547–53 | date = Feb 1993 | pmid = 8441666 | pmc = 309151 | doi = 10.1093/nar/21.3.547 }}
*{{cite journal | author=Friedman LS, Ostermeyer EA, Lynch ED, ''et al.'' |title=The search for BRCA1. |journal=Cancer Res. |volume=54 |issue= 24 |pages= 6374-82 |year= 1995 |pmid= 7987831 |doi=  }}
* {{cite journal | vauthors = Urano F, Umezawa A, Hong W, Kikuchi H, Hata J | title = A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma | journal = Biochemical and Biophysical Research Communications | volume = 219 | issue = 2 | pages = 608–12 | date = Feb 1996 | pmid = 8605035 | doi = 10.1006/bbrc.1996.0281 }}
*{{cite journal | author=Higashino F, Yoshida K, Fujinaga Y, ''et al.'' |title=Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family. |journal=Nucleic Acids Res. |volume=21 |issue= 3 |pages= 547-53 |year= 1993 |pmid= 8441666 |doi= }}
* {{cite journal | vauthors = Coutte L, Monté D, Baert J, de Launoit Y | title = Genomic organization of the human e1af gene,a member of Ets transcription factors | journal = Gene | volume = 240 | issue = 1 | pages = 201–7 | date = Nov 1999 | pmid = 10564827 | doi = 10.1016/S0378-1119(99)00400-X }}
*{{cite journal | author=Isobe M, Yamagishi F, Yoshida K, ''et al.'' |title=Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21. |journal=Genomics |volume=28 |issue= 2 |pages= 357-9 |year= 1996 |pmid= 8530053 |doi= 10.1006/geno.1995.1158 }}
* {{cite journal | vauthors = Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA, Sozzi G | title = A novel zinc finger gene is fused to EWS in small round cell tumor | journal = Oncogene | volume = 19 | issue = 33 | pages = 3799–804 | date = Aug 2000 | pmid = 10949935 | doi = 10.1038/sj.onc.1203762 }}
*{{cite journal | author=Urano F, Umezawa A, Hong W, ''et al.'' |title=A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. |journal=Biochem. Biophys. Res. Commun. |volume=219 |issue= 2 |pages= 608-12 |year= 1996 |pmid= 8605035 |doi= }}
* {{cite journal | vauthors = Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Reich R | title = PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma | journal = Clinical Cancer Research | volume = 9 | issue = 4 | pages = 1412–9 | date = Apr 2003 | pmid = 12684413 | doi = }}
*{{cite journal | author=Coutte L, Monté D, Baert J, de Launoit Y |title=Genomic organization of the human e1af gene,a member of Ets transcription factors. |journal=Gene |volume=240 |issue= 1 |pages= 201-7 |year= 2000 |pmid= 10564827 |doi= }}
* {{cite journal | vauthors = Span PN, Manders P, Heuvel JJ, Beex LV, Sweep CG | title = E1AF expression levels are not associated with prognosis in human breast cancer | journal = Breast Cancer Research and Treatment | volume = 79 | issue = 1 | pages = 129–31 | date = May 2003 | pmid = 12779089 | doi = 10.1023/A:1023338424677 }}
*{{cite journal | author=Mastrangelo T, Modena P, Tornielli S, ''et al.'' |title=A novel zinc finger gene is fused to EWS in small round cell tumor. |journal=Oncogene |volume=19 |issue= 33 |pages= 3799-804 |year= 2000 |pmid= 10949935 |doi= 10.1038/sj.onc.1203762 }}
* {{cite journal | vauthors = Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A | title = The human plasma proteome: a nonredundant list developed by combination of four separate sources | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 4 | pages = 311–26 | date = Apr 2004 | pmid = 14718574 | doi = 10.1074/mcp.M300127-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Liu Y, Borchert GL, Phang JM | title = Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 18694–700 | date = Apr 2004 | pmid = 14976201 | doi = 10.1074/jbc.M308136200 }}
*{{cite journal | author=Davidson B, Goldberg I, Gotlieb WH, ''et al.'' |title=PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. |journal=Clin. Cancer Res. |volume=9 |issue= 4 |pages= 1412-9 |year= 2004 |pmid= 12684413 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Span PN, Manders P, Heuvel JJ, ''et al.'' |title=E1AF expression levels are not associated with prognosis in human breast cancer. |journal=Breast Cancer Res. Treat. |volume=79 |issue= 1 |pages= 129-31 |year= 2004 |pmid= 12779089 |doi= }}
* {{cite journal | vauthors = Davidson B, Goldberg I, Tell L, Vigdorchik S, Baekelandt M, Berner A, Kristensen GB, Reich R, Kopolovic J | title = The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions | journal = Clinical & Experimental Metastasis | volume = 21 | issue = 3 | pages = 191–9 | year = 2004 | pmid = 15387369 | doi = 10.1023/B:CLIN.0000037703.37275.35 }}
*{{cite journal | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
* {{cite journal | vauthors = Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I | title = The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells | journal = The Biochemical Journal | volume = 386 | issue = Pt 1 | pages = 35–45 | date = Feb 2005 | pmid = 15461591 | pmc = 1134764 | doi = 10.1042/BJ20040706 }}
*{{cite journal | author=Liu Y, Borchert GL, Phang JM |title=Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18694-700 |year= 2004 |pmid= 14976201 |doi= 10.1074/jbc.M308136200 }}
* {{cite journal | vauthors = Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, Yang Y, Niu Z, Liu W, Chen X, Hu Y, Gu J | title = Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator | journal = The Journal of Biological Chemistry | volume = 280 | issue = 13 | pages = 12503–16 | date = Apr 2005 | pmid = 15611127 | doi = 10.1074/jbc.M413631200 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M | title = E1AF degradation by a ubiquitin-proteasome pathway | journal = Biochemical and Biophysical Research Communications | volume = 327 | issue = 2 | pages = 575–80 | date = Feb 2005 | pmid = 15629152 | doi = 10.1016/j.bbrc.2004.12.045 }}
*{{cite journal | author=Davidson B, Goldberg I, Tell L, ''et al.'' |title=The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions. |journal=Clin. Exp. Metastasis |volume=21 |issue= 3 |pages= 191-9 |year= 2004 |pmid= 15387369 |doi= }}
* {{cite journal | vauthors = Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K | title = Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis | journal = Carcinogenesis | volume = 26 | issue = 5 | pages = 892–9 | date = May 2005 | pmid = 15695237 | doi = 10.1093/carcin/bgi029 }}
*{{cite journal | author=Fauquette V, Perrais M, Cerulis S, ''et al.'' |title=The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. |journal=Biochem. J. |volume=386 |issue= Pt 1 |pages= 35-45 |year= 2005 |pmid= 15461591 |doi= 10.1042/BJ20040706 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhu X, Jiang J, Shen H, ''et al.'' |title=Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12503-16 |year= 2005 |pmid= 15611127 |doi= 10.1074/jbc.M413631200 }}
*{{cite journal  | author=Takahashi A, Higashino F, Aoyagi M, ''et al.'' |title=E1AF degradation by a ubiquitin-proteasome pathway. |journal=Biochem. Biophys. Res. Commun. |volume=327 |issue= 2 |pages= 575-80 |year= 2005 |pmid= 15629152 |doi= 10.1016/j.bbrc.2004.12.045 }}
*{{cite journal  | author=Nosho K, Yoshida M, Yamamoto H, ''et al.'' |title=Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. |journal=Carcinogenesis |volume=26 |issue= 5 |pages= 892-9 |year= 2005 |pmid= 15695237 |doi= 10.1093/carcin/bgi029 }}
}}
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* {{MeshName|ETV4+protein,+human}}
* {{MeshName|ETV4+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-17-stub}}

Latest revision as of 00:38, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.[1][2]

References

  1. ↑ Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.
  2. ↑ "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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