E4F1
| E4F transcription factor 1 | |||||||||||
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| Symbols | E4F1 ; E4F; MGC99614 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3259 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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E4F transcription factor 1, also known as E4F1, is a human gene.[1]
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Burn TC, Connors TD, Van Raay TJ; et al. (1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–37. PMID 8828041.
- Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3". Mol. Cell. Biol. 17 (4): 1890–903. PMID 9121437.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Rooney RJ, Daniels RR, Jenkins NA; et al. (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice". Mamm. Genome. 9 (4): 320–3. PMID 9530632.
- Saccone S, Sandy P, Meroni G; et al. (1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet. Cell Genet. 82 (1–2): 99–100. PMID 9763670.
- Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. PMID 10608806.
- Sandy P, Gostissa M, Fogal V; et al. (2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996.
- Fajas L, Paul C, Zugasti O; et al. (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMID 10869426.
- Rizos H, Diefenbach E, Badhwar P; et al. (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Fenton SL, Dallol A, Agathanggelou A; et al. (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene". Cancer Res. 64 (1): 102–7. PMID 14729613.
- Nakamura Y, Igarashi K, Suzuki T; et al. (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis". Am. J. Pathol. 165 (6): 2019–31. PMID 15579445.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Paul C, Lacroix M, Iankova I; et al. (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1". Oncogene. 25 (40): 5475–84. doi:10.1038/sj.onc.1209567. PMID 16652157.
- Le Cam L, Linares LK, Paul C; et al. (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation". Cell. 127 (4): 775–88. doi:10.1016/j.cell.2006.09.031. PMID 17110336.
- Cvetanovic M, Rooney RJ, Garcia JJ; et al. (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression". EMBO Rep. 8 (7): 671–7. doi:10.1038/sj.embor.7400983. PMID 17557114.
External links
- E4F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.