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{{Caplans syndrome}}


==Overview==
==Overview==


In 1953, the [[chest x ray]] findings of [[multiple pulmonary nodules]], in the [[coal miners]] with [[Rheumatoid Arthritis]](RA) of Welsh, was described by Caplan. In 13 coal miners with RA, along with the small silicotic [[nodules]], well defined, larger lung nodules were found. Caplan identified that miners with [[Pulmonary|pulmonary]] [[nodules]] on chest x ray eventually developed [[arthritis]] though they were not diagnosed cases of RA. Though Caplan's initial idea was of [[infectious]] etiology, two years later several cases of ' [[rheumatoid pneumoconiosis]]' with [[tuberculosis]] were reported. But the theory of [[rheumatoid pneumoconiosis]] and [[tuberculous pneumoconiosis]] got rejected by the time. Caplan's [[syndrome]] concept was expanded to cover the exposure to all [[inorganic]] dusts from different sources.
In 1953, the [[chest x ray]] findings of [[multiple pulmonary nodules]], in the [[coal miners]] with [[Rheumatoid Arthritis]](RA) of Welsh, was described by Caplan. In 13 coal miners with RA, along with the small silicotic [[nodules]], well-defined, larger lung nodules were found. Caplan identified that miners with [[Pulmonary|pulmonary]] [[nodules]] on chest x-ray eventually developed [[arthritis]] though they have not diagnosed cases of RA. Though Caplan's initial idea was of [[infectious]] etiology, two years later several cases of ' [[rheumatoid pneumoconiosis]]' with [[tuberculosis]] were reported. But the theory of [[rheumatoid pneumoconiosis]] and [[tuberculous pneumoconiosis]] got rejected by time. Caplan's [[syndrome]] concept was expanded to cover the exposure to all [[inorganic]] dust from different sources. In 1940 and 1950, rheumatoid [[nodules]] were identified by several authors in autopsy studies of different organs as [[heart]] and [[lungs]]. But the relation to [[silica]] exposure was not discussed. Years later after Caplan's publication, multiple cases with [[pulmonary]] [[nodules]] in miners with RA were reported. But 20 cases with lung nodules were reported without any dust exposure.
In 1940 and 1950, rheumatoid [[nodules]] were identified by several authors in autopsy studies of different organs as [[heart]] and [[lungs]]. But relation to [[silica]] exposure was not discussed. Years later after Caplan's publication, multiple cases with [[pulmonary]] [[nodules]] in miners with RA were reported. But 20 cases with lung nodules were reported without any dust exposure.
 
==Historical Perspective==
==Historical Perspective==
===Discovery===
===Discovery===
*[[Caplan Syndrome]] was first discovered by Dr. Anthony Caplan, a British physician, in 1953.
*In 1955, theory of [[tuberculous]] [[rheumatism]] and [[tuberculous]] [[pneumoconiosis]] were developed which got abandoned later.
* In 1940 and 1955, rheumatoid nodules were described in [[autopsy]] study of [[heart]] and [[lungs]].
* In 1948, Ellman and Ball reported the [[pulmonary]] [[nodules]] found in coal miners were prevalent only in men with dust exposures and not related to ordinary [[silicosis]] or [[rheumatoid arthritis]].
* An [[epidemiological]] study was conducted by Miall and associates in 1955 to determine the validity of [[Caplan syndrome]].
* In 1958, J. Gough described the [[histological]] criterias to [[diagnose]] [[Caplan syndrome]].<ref name="SchreiberKoschel2010">{{cite journal|last1=Schreiber|first1=J.|last2=Koschel|first2=D.|last3=Kekow|first3=J.|last4=Waldburg|first4=N.|last5=Goette|first5=A.|last6=Merget|first6=R.|title=Rheumatoid pneumoconiosis (Caplan's syndrome)|journal=European Journal of Internal Medicine|volume=21|issue=3|year=2010|pages=168–172|issn=09536205|doi=10.1016/j.ejim.2010.02.004}}</ref> <ref name="GoughRivers1955">{{cite journal|last1=Gough|first1=J.|last2=Rivers|first2=D.|last3=Seal|first3=R. M. E.|title=Pathological Studies of Modified Pneumoconiosis in Coal-miners with Rheumatoid Arthritis (Caplan's Syndrome)|journal=Thorax|volume=10|issue=1|year=1955|pages=9–18|issn=0040-6376|doi=10.1136/thx.10.1.9}}</ref> <ref>{{cite journal|doi=10.1164/artpd.1958.78.2.274?journalCode=artpd}}</ref>


===Landmark Events in the Development of Treatment Strategies===


*[[Caplan Syndrome]] was first discovered by Dr. Anthony Caplan, a British physician, in 1953.<ref name="SchreiberKoschel2010">{{cite journal|last1=Schreiber|first1=J.|last2=Koschel|first2=D.|last3=Kekow|first3=J.|last4=Waldburg|first4=N.|last5=Goette|first5=A.|last6=Merget|first6=R.|title=Rheumatoid pneumoconiosis (Caplan's syndrome)|journal=European Journal of Internal Medicine|volume=21|issue=3|year=2010|pages=168–172|issn=09536205|doi=10.1016/j.ejim.2010.02.004}}</ref>
*[[Caplan's syndrome]] was originally described in coal miners with progressive massive [[fibrosis]] by Caplan in 1953.<ref name="GoughRivers1955">{{cite journal|last1=Gough|first1=J.|last2=Rivers|first2=D.|last3=Seal|first3=R. M. E.|title=Pathological Studies of Modified Pneumoconiosis in Coal-miners with Rheumatoid Arthritis (Caplan's Syndrome)|journal=Thorax|volume=10|issue=1|year=1955|pages=9–18|issn=0040-6376|doi=10.1136/thx.10.1.9}}</ref>
 
*The association between [[intrapulmonary nodules]] and [[rheumatoid arthritis]] was made in the radiologic findings of [[chest x ray]] in the [[coal miners]].
 
===Landmark Events in the Development of Treatment Strategies===


Caplan's syndrome was originally described in coal miners with progressive massive [[fibrosis]].
* In 1955, the first [[epidemiological]] study was conducted to validate the [[criteria]] of [[Caplan syndrome]].
* J. Gough reported the [[histological]] [[diagnostic]] findings for Caplan Syndrome in 1958.


==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 03:35, 21 June 2021

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S

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Overview

In 1953, the chest x ray findings of multiple pulmonary nodules, in the coal miners with Rheumatoid Arthritis(RA) of Welsh, was described by Caplan. In 13 coal miners with RA, along with the small silicotic nodules, well-defined, larger lung nodules were found. Caplan identified that miners with pulmonary nodules on chest x-ray eventually developed arthritis though they have not diagnosed cases of RA. Though Caplan's initial idea was of infectious etiology, two years later several cases of ' rheumatoid pneumoconiosis' with tuberculosis were reported. But the theory of rheumatoid pneumoconiosis and tuberculous pneumoconiosis got rejected by time. Caplan's syndrome concept was expanded to cover the exposure to all inorganic dust from different sources. In 1940 and 1950, rheumatoid nodules were identified by several authors in autopsy studies of different organs as heart and lungs. But the relation to silica exposure was not discussed. Years later after Caplan's publication, multiple cases with pulmonary nodules in miners with RA were reported. But 20 cases with lung nodules were reported without any dust exposure.

Historical Perspective

Discovery

Landmark Events in the Development of Treatment Strategies

References

  1. Schreiber, J.; Koschel, D.; Kekow, J.; Waldburg, N.; Goette, A.; Merget, R. (2010). "Rheumatoid pneumoconiosis (Caplan's syndrome)". European Journal of Internal Medicine. 21 (3): 168–172. doi:10.1016/j.ejim.2010.02.004. ISSN 0953-6205.
  2. 2.0 2.1 Gough, J.; Rivers, D.; Seal, R. M. E. (1955). "Pathological Studies of Modified Pneumoconiosis in Coal-miners with Rheumatoid Arthritis (Caplan's Syndrome)". Thorax. 10 (1): 9–18. doi:10.1136/thx.10.1.9. ISSN 0040-6376.
  3. . doi:10.1164/artpd.1958.78.2.274?journalCode=artpd. Missing or empty |title= (help)