Caplans syndrome epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S

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The incidence of Caplan syndrome is 1 in 100,000 people but it is decreasing due to the reduction of exposure to coal, silica, and asbestos. Silica exposure has the most prevalence of Caplan syndrome.

Epidemiology and Demographics


  • Caplan syndrome is very rare in the United States. Incidence is currently 1 in 100,000 people but is likely to fall as the coal mining industry declines.[1]


case-fatality rate/Mortality rate

  • Mortality rate in Caplan syndrome is very low except in association with black lung caused by coal worker pneumoconiosis.[3]


  • Aveerage age of first radiographic appearance of Caplan syndrome is 54 years. The age range is 41 to 64 years of age. [4][5]


  • There is no racial predilection to Caplan syndrome.


  • There is no study available on gender.


  • The majority of Caplan syndrome cases are reported 0.75% in Japan and 1.5% in the United States.[6]


  1. 1.0 1.1 "StatPearls". 2021. PMID 29763061. PMID: 29763061. Check |pmid= value (help).
  2. Benedek, Thomas G. (1973). "Rheumatoid pneumoconiosis". The American Journal of Medicine. 55 (4): 515–524. doi:10.1016/0002-9343(73)90209-X. ISSN 0002-9343.
  3. Shaw, Megan; Collins, Bridget F.; Ho, Lawrence A.; Raghu, Ganesh (2015). "Rheumatoid arthritis-associated lung disease". European Respiratory Review. 24 (135): 1–16. doi:10.1183/09059180.00008014. ISSN 0905-9180.
  4. Lindars, D. C.; Davies, D. (1967). "Rheumatoid pneumoconiosis: A study in colliery populations in the East Midlands coalfield". Thorax. 22 (6): 525–532. doi:10.1136/thx.22.6.525. ISSN 0040-6376.
  5. Alaya, Zeineb; Braham, Mouna; Aissa, Sana; Kalboussi, Houda; Bouajina, Elyès (2018). "A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report". Radiology Case Reports. 13 (3): 663–666. doi:10.1016/j.radcr.2018.03.004. ISSN 1930-0433.
  6. "Rheumatoid Pneumoconiosis: A Comparative Study of Autopsy Cases between Japan and North America". The Annals of Occupational Hygiene. 2002. doi:10.1093/annhyg/46.suppl_1.265. ISSN 1475-3162.