Caplans syndrome pathophysiology

Jump to navigation Jump to search

Caplans syndrome Microchapters


Patient Information


Historical Perspective




Differentiating Caplans syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray



Other Imaging Findings

Other Diagnostic Studies


Medical Therapy


Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Caplans syndrome pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Caplans syndrome pathophysiology

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Caplans syndrome pathophysiology

CDC on Caplans syndrome pathophysiology

Caplans syndrome pathophysiology in the news

Blogs on Caplans syndrome pathophysiology

Directions to Hospitals Treating Type page name here

Risk calculators and risk factors for Caplans syndrome pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S


Caplan Syndrome is known as Rheumatoid pneumoconiosis. In patients with rheumatoid arthritis, lungs show increased immune response to the foreign materials. In coal miners with RA, exposure to silica causes the release of different cytokines as interleukin-1,granulocyte colony stimulating factor and tumor necrosis factor-alpha by monocytes and macrophages. Lymphocytes get activated by the cytokines and leading to hyperactive autoimmune response.




Associated Conditions

Conditions associated with [disease name] include:

Gross Pathology

Some people who have been exposed to the dust have severe lung scarring that makes it difficult for their lungs to carry oxygen to the bloodstream (called progressive massive fibrosis). People with rheumatoid arthritis do not seem more likely to have this complication of scarring.

Persons with rheumatoid arthritis are more likely to develop larger areas of inflammation and scarring in response to coal dust.

Microscopic Pathology

Microscopic features of Caplan syndrome are


  1. 1.0 1.1 Schreiber, J.; Koschel, D.; Kekow, J.; Waldburg, N.; Goette, A.; Merget, R. (2010). "Rheumatoid pneumoconiosis (Caplan's syndrome)". European Journal of Internal Medicine. 21 (3): 168–172. doi:10.1016/j.ejim.2010.02.004. ISSN 0953-6205.
  2. Gough, J.; Rivers, D.; Seal, R. M. E. (1955). "Pathological Studies of Modified Pneumoconiosis in Coal-miners with Rheumatoid Arthritis (Caplan's Syndrome)". Thorax. 10 (1): 9–18. doi:10.1136/thx.10.1.9. ISSN 0040-6376.
  3. . doi:10.1164/artpd.1958.78.2.274?journalCode=artpd. Missing or empty |title= (help)