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[[File:SARS-CoV-2 49534865371.jpg|thumb|Electron micrograph of SARS-CoV-2 virions with visible coronae
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{{COVID-19}}
'''For COVID-19 frequently asked inpatient questions, click [[COVID-19 frequently asked inpatient questions|here]]'''<br>
'''For COVID-19 frequently asked outpatient questions, click [[COVID-19 frequently asked outpatient questions|here]]'''<br>


<nowiki>https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2#/media/File:SARS-CoV-2_49534865371.jpg</nowiki>|624x624px]]
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==Overview==
==Overview==


[[Coronavirus]], named due to the "crown" like the appearance of its surface projections, was first isolated from chickens in 1937. The etiological agent, a [[Novel coronavirus|novel]] [[coronavirus]], [[SARS-CoV-2|severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)]], named for the similarity of its symptoms to those induced by the severe [[Acute respiratory distress syndrome|acute respiratory syndrome]], causing [[coronavirus]] disease 2019 ([[COVID-19]]), is a [[virus]] identified as the cause of an outbreak of [[respiratory illness]] first detected in Wuhan, China.
==Historical Perspective==
==Historical Perspective==
According to the WHO report, their office in china called "WHO China Country Office" on 31 December 2019, the WHO China Country Office was informed as a new type of  pneumonia cases with unknown etiology at that time (31 December 2019) in Wuhan City, Hubei Province of China.  
*[[Coronavirus]], named due to the "crown" like the appearance of its surface projections, was first isolated from chickens in 1937.
 
* In 1965, Tyrrell and Bynoe used cultures of human [[Cilia|ciliated]] [[Embryo|embryonal]] [[trachea]] to propagate the first human [[coronavirus]] (HCoV) [[in vitro]].
As of 3 January 2020, a total of 44 cases with that pneumonia due to the unknown etiology have been reported to WHO by the national authorities in China:
* There are now approximately 15 [[species]] in this family, which infect not only humans but cattle, pigs, rodents, cats, dogs and birds (some are serious veterinary [[Pathogen|pathogens]], especially those that infect chickens).
 
* 11 case were severely ill.
* 33 remaining patients were stable.
 
Accordingly, the concerned market in Wuhan was closed on 1 January 2020 for environmental sanitation and disinfection. After that illness was not identified or confirmed. On 1 January 2020, then WHO requested further information from national authorities to assess the related risks and affect of this illness. The china reported to WHO that all patients were isolated and underwent medical treatment in Wuhan medical institutions. The related clinical signs and symptoms were consisted of:
 
* fever
* difficulty in breathing
* chest radiography showing invasive lesions of both lungs
 
In a recent study published by Xiaolu Tang et al on 03 March 2020 at Peking University's School of Life Sciences and the Institut Pasteur of Shanghai, they have mentioned that they have concluded that there is a more aggressive type of the new coronavirus had responsible for around 70% of analyzed strains, while the remain 30% had been linked to a less aggressive type of the coronavirus.


The aggressive type of the coronavirus was prevalent in the early outbreak in Wuhan the Chinese city where COVID-19 was first detected on 31 December 2019, but the frequency of this type of virus has since decreased from the beginning of this outbreak. and the Xiaolu Tang et al concluded that this aggresive type of this disease could be caused by mutations and natural selection of the spike in COVID-19. And more studies were recommended by those researchers.
* The etiological agent, a [[novel coronavirus]], [[SARS-CoV-2]], named for the similarity of its symptoms to those induced by the [[severe acute respiratory syndrome]], causing [[coronavirus]] disease 2019 ([[COVID-19]]), is a [[virus]] identified as the cause of an outbreak of [[respiratory illness]] first detected in Wuhan, China.<ref>{{Cite web|url=https://www.cdc.gov/coronavirus/2019-ncov/about/index.html|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref><ref name="LuCui2020">{{cite journal|last1=Lu|first1=Jian|last2=Cui|first2=Jie|last3=Qian|first3=Zhaohui|last4=Wang|first4=Yirong|last5=Zhang|first5=Hong|last6=Duan|first6=Yuange|last7=Wu|first7=Xinkai|last8=Yao|first8=Xinmin|last9=Song|first9=Yuhe|last10=Li|first10=Xiang|last11=Wu|first11=Changcheng|last12=Tang|first12=Xiaolu|title=On the origin and continuing evolution of SARS-CoV-2|journal=National Science Review|year=2020|issn=2095-5138|doi=10.1093/nsr/nwaa036}}</ref>
*Initially, the [[Patient|patients]] were believed to have contracted the [[virus]] from [[seafood]]/animal markets which suggested animal-to-human spread.
*The growing number of [[patients]] however, suggest that human-to-human transmission is actively occurring.<ref name="HuangWang2020">{{cite journal|last1=Huang|first1=Chaolin|last2=Wang|first2=Yeming|last3=Li|first3=Xingwang|last4=Ren|first4=Lili|last5=Zhao|first5=Jianping|last6=Hu|first6=Yi|last7=Zhang|first7=Li|last8=Fan|first8=Guohui|last9=Xu|first9=Jiuyang|last10=Gu|first10=Xiaoying|last11=Cheng|first11=Zhenshun|last12=Yu|first12=Ting|last13=Xia|first13=Jiaan|last14=Wei|first14=Yuan|last15=Wu|first15=Wenjuan|last16=Xie|first16=Xuelei|last17=Yin|first17=Wen|last18=Li|first18=Hui|last19=Liu|first19=Min|last20=Xiao|first20=Yan|last21=Gao|first21=Hong|last22=Guo|first22=Li|last23=Xie|first23=Jungang|last24=Wang|first24=Guangfa|last25=Jiang|first25=Rongmeng|last26=Gao|first26=Zhancheng|last27=Jin|first27=Qi|last28=Wang|first28=Jianwei|last29=Cao|first29=Bin|title=Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China|journal=The Lancet|volume=395|issue=10223|year=2020|pages=497–506|issn=01406736|doi=10.1016/S0140-6736(20)30183-5}}</ref><ref>{{Cite web|url=https://www.cdc.gov/coronavirus/2019-ncov/about/transmission.html|title=|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}</ref>
*The outbreak was declared a Public Health Emergency of International Concern on 30 January 2020.
*On March 12, 2020, the World Health Organization declared the [[COVID-19]] outbreak a [[pandemic]].


==References==
==References==
 
{{reflist|2}}
 
{{WH}}
[[Category: Infectious disease]]
 
{{WS}}
{{WS}}
{{WH}}
[[Category:Nidovirales]]
[[Category:Animal virology]]

Latest revision as of 13:38, 21 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

Coronavirus, named due to the "crown" like the appearance of its surface projections, was first isolated from chickens in 1937. The etiological agent, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), named for the similarity of its symptoms to those induced by the severe acute respiratory syndrome, causing coronavirus disease 2019 (COVID-19), is a virus identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China.

Historical Perspective

  • Coronavirus, named due to the "crown" like the appearance of its surface projections, was first isolated from chickens in 1937.
  • In 1965, Tyrrell and Bynoe used cultures of human ciliated embryonal trachea to propagate the first human coronavirus (HCoV) in vitro.
  • There are now approximately 15 species in this family, which infect not only humans but cattle, pigs, rodents, cats, dogs and birds (some are serious veterinary pathogens, especially those that infect chickens).

References

  1. https://www.cdc.gov/coronavirus/2019-ncov/about/index.html. Missing or empty |title= (help)
  2. Lu, Jian; Cui, Jie; Qian, Zhaohui; Wang, Yirong; Zhang, Hong; Duan, Yuange; Wu, Xinkai; Yao, Xinmin; Song, Yuhe; Li, Xiang; Wu, Changcheng; Tang, Xiaolu (2020). "On the origin and continuing evolution of SARS-CoV-2". National Science Review. doi:10.1093/nsr/nwaa036. ISSN 2095-5138.
  3. Huang, Chaolin; Wang, Yeming; Li, Xingwang; Ren, Lili; Zhao, Jianping; Hu, Yi; Zhang, Li; Fan, Guohui; Xu, Jiuyang; Gu, Xiaoying; Cheng, Zhenshun; Yu, Ting; Xia, Jiaan; Wei, Yuan; Wu, Wenjuan; Xie, Xuelei; Yin, Wen; Li, Hui; Liu, Min; Xiao, Yan; Gao, Hong; Guo, Li; Xie, Jungang; Wang, Guangfa; Jiang, Rongmeng; Gao, Zhancheng; Jin, Qi; Wang, Jianwei; Cao, Bin (2020). "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China". The Lancet. 395 (10223): 497–506. doi:10.1016/S0140-6736(20)30183-5. ISSN 0140-6736.
  4. https://www.cdc.gov/coronavirus/2019-ncov/about/transmission.html. Missing or empty |title= (help)

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