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{{Infobox_gene}}
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'''COUP-TFII''' ('''COUP transcription factor 2'''), also known as '''NR2F2''' (nuclear receptor subfamily 2, group F, member 2) is a [[protein]] that in humans is encoded by the ''NR2F2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7026| accessdate = }}</ref><ref name="pmid8530078">{{cite journal | vauthors = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | date = September 1995 | pmid = 8530078 | doi = 10.1006/geno.1995.1237 }}</ref> The COUP acronym stands for '''c'''hicken '''o'''valbumin '''u'''pstream '''p'''romoter.
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor subfamily 2, group F, member 2
| HGNCid = 7976
| Symbol = NR2F2
| AltSymbols =; ARP1; COUP-TFII; COUPTFB; MGC117452; SVP40; TFCOUP2
| OMIM = 107773
| ECnumber = 
| Homologene = 7628
| MGIid = 1352452
| GeneAtlas_image1 = PBB_GE_NR2F2_209120_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR2F2_209121_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_NR2F2_215073_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003706 |text = ligand-regulated transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0009956 |text = radial pattern formation}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0048514 |text = blood vessel morphogenesis}} {{GNF_GO|id=GO:0048637 |text = skeletal muscle development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7026
    | Hs_Ensembl = ENSG00000185551
    | Hs_RefseqProtein = NP_066285
    | Hs_RefseqmRNA = NM_021005
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 94674950
    | Hs_GenLoc_end = 94683045
    | Hs_Uniprot = P24468
    | Mm_EntrezGene = 11819
    | Mm_Ensembl = ENSMUSG00000030551
    | Mm_RefseqmRNA = NM_009697
    | Mm_RefseqProtein = NP_033827
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 70226952
    | Mm_GenLoc_end = 70240235
    | Mm_Uniprot = Q3UST6
  }}
}}
'''COUP-TFII''' ('''COUP transcription factor 2'''), also known as '''NR2F2''' (nuclear receptor subfamily 2, group F, member 2) is a human protein encoded by the {{gene|NR2F2}} gene.<ref name="entrez">{{cite web | title = Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7026| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.<ref name="pmid10215630">{{cite journal | vauthors = Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY | title = The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development | journal = Genes Dev. | volume = 13 | issue = 8 | pages = 1037–49 | date = April 1999 | pmid = 10215630 | pmc = 316637 | doi = 10.1101/gad.13.8.1037 }}</ref><ref name="pmid15572686">{{cite journal | vauthors = Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY | title = The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development | journal = Mol. Cell. Biol. | volume = 24 | issue = 24 | pages = 10835–43 | date = December 2004 | pmid = 15572686 | pmc = 533959 | doi = 10.1128/MCB.24.24.10835-10843.2004 }}</ref>
{{PBB_Summary
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| summary_text =  
}}


==References==
The [[glucocorticoid receptor]] (GR) stimulates COUP-TFII-induced [[transactivation]] while COUP-TFII represses the GR transcriptional activity.<ref name="pmid14739255">{{cite journal | vauthors = De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T | title = The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism | journal = Mol. Endocrinol. | volume = 18 | issue = 4 | pages = 820–33 | date = April 2004 | pmid = 14739255 | doi = 10.1210/me.2003-0341 }}</ref><ref name="pmid15265774">{{cite journal | vauthors = De Martino MU, Alesci S, Chrousos GP, Kino T | title = Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism | journal = Ann. N. Y. Acad. Sci. | volume = 1024 | issue =  | pages = 72–85 | date = June 2004 | pmid = 15265774 | doi = 10.1196/annals.1321.006 }}</ref> COUP-TFII interacts with [[GATA2]] to inhibit [[adipocyte]] [[cellular differentiation|differentiation]].<ref name="pmid18250317">{{cite journal | vauthors = Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED | title = The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 7 | pages = 2421–6 | date = February 2008 | pmid = 18250317 | pmc = 2268152 | doi = 10.1073/pnas.0707082105 }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
COUP-TFII has been shown to [[Protein-protein interaction|interact]] with:
* [[HDAC1]]<ref name="pmid10704340">{{cite journal | vauthors = Smirnov DA, Hou S, Ricciardi RP | title = Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription | journal = Virology | volume = 268 | issue = 2 | pages = 319–28 | date = March 2000 | pmid = 10704340 | doi = 10.1006/viro.1999.0181 }}</ref>
* [[Lck]]<ref name="pmid8910285">{{cite journal | vauthors = Marcus SL, Winrow CJ, Capone JP, Rachubinski RA | title = A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27197–200 | date = November 1996 | pmid = 8910285 | doi = 10.1074/jbc.271.44.27197 }}</ref>
* [[V-erbA-related gene]].<ref name="pmid10318855">{{cite journal | vauthors = Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M | title = Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 | journal = J. Biol. Chem. | volume = 274 | issue = 20 | pages = 14331–6 | date = May 1999 | pmid = 10318855 | pmc = 2823254 | doi = 10.1074/jbc.274.20.14331 }}</ref>
*  [[Nucleolin]]<ref name="pmid22693611">{{cite journal | vauthors = Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM | title = Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells. | journal = PLOS ONE | volume = 7 | issue = 5 | date = May 2012 | pmc = 3365040 | doi = 10.1371/journal.pone.0038278 | pmid = 22693611 | pages=e38278}}</ref>
 
== References ==
{{Reflist|2}}
 
==External links==
* {{UCSC gene info|NR2F1}}
* {{UCSC gene info|NR2F2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = De Martino MU, Alesci S, Chrousos GP, Kino T | title = Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism | journal = Ann. N. Y. Acad. Sci. | volume = 1024 | issue =  | pages = 72–85 | year = 2004 | pmid = 15265774 | doi = 10.1196/annals.1321.006 }}
| citations =
* {{cite journal | vauthors = Mietus-Snyder M, Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE, Karathanasis SK | title = Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells | journal = Mol. Cell. Biol. | volume = 12 | issue = 4 | pages = 1708–18 | year = 1992 | pmid = 1312668 | pmc = 369614 | doi =  }}
*{{cite journal | author=De Martino MU, Alesci S, Chrousos GP, Kino T |title=Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism. |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue=  |pages= 72-85 |year= 2004 |pmid= 15265774 |doi= 10.1196/annals.1321.006 }}
* {{cite journal | vauthors = Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ | title = The COUP-TFs compose a family of functionally related transcription factors | journal = Gene Expr. | volume = 1 | issue = 3 | pages = 207–16 | year = 1992 | pmid = 1820218 | doi =  }}
*{{cite journal | author=Mietus-Snyder M, Sladek FM, Ginsburg GS, ''et al.'' |title=Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. |journal=Mol. Cell. Biol. |volume=12 |issue= 4 |pages= 1708-18 |year= 1992 |pmid= 1312668 |doi=  }}
* {{cite journal | vauthors = Ladias JA, Karathanasis SK | title = Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily | journal = Science | volume = 251 | issue = 4993 | pages = 561–5 | year = 1991 | pmid = 1899293 | doi = 10.1126/science.1899293 }}
*{{cite journal | author=Wang LH, Ing NH, Tsai SY, ''et al.'' |title=The COUP-TFs compose a family of functionally related transcription factors. |journal=Gene Expr. |volume=1 |issue= 3 |pages= 207-16 |year= 1992 |pmid= 1820218 |doi=  }}
* {{cite journal | vauthors = Marcus SL, Winrow CJ, Capone JP, Rachubinski RA | title = A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27197–200 | year = 1996 | pmid = 8910285 | doi = 10.1074/jbc.271.44.27197 }}
*{{cite journal | author=Ladias JA, Karathanasis SK |title=Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. |journal=Science |volume=251 |issue= 4993 |pages= 561-5 |year= 1991 |pmid= 1899293 |doi= }}
* {{cite journal | vauthors = Thénot S, Henriquet C, Rochefort H, Cavaillès V | title = Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 | journal = J. Biol. Chem. | volume = 272 | issue = 18 | pages = 12062–8 | year = 1997 | pmid = 9115274 | doi = 10.1074/jbc.272.18.12062 }}
*{{cite journal | author=Qiu Y, Krishnan V, Zeng Z, ''et al.'' |title=Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. |journal=Genomics |volume=29 |issue= 1 |pages= 240-6 |year= 1996 |pmid= 8530078 |doi= }}
* {{cite journal | vauthors = Chu K, Zingg HH | title = The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter | journal = J. Mol. Endocrinol. | volume = 19 | issue = 2 | pages = 163–72 | year = 1998 | pmid = 9343308 | doi = 10.1677/jme.0.0190163 }}
*{{cite journal | author=Marcus SL, Winrow CJ, Capone JP, Rachubinski RA |title=A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27197-200 |year= 1996 |pmid= 8910285 |doi= }}
* {{cite journal | vauthors = Bailey P, Sartorelli V, Hamamori Y, Muscat GE | title = The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD | journal = Nucleic Acids Res. | volume = 26 | issue = 23 | pages = 5501–10 | year = 1999 | pmid = 9826778 | pmc = 147985 | doi = 10.1093/nar/26.23.5501 }}
*{{cite journal | author=Thénot S, Henriquet C, Rochefort H, Cavaillès V |title=Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 12062-8 |year= 1997 |pmid= 9115274 |doi= }}
* {{cite journal | vauthors = Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M | title = Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2 | journal = J. Biol. Chem. | volume = 274 | issue = 20 | pages = 14331–6 | year = 1999 | pmid = 10318855 | pmc = 2823254 | doi = 10.1074/jbc.274.20.14331 }}
*{{cite journal | author=Chu K, Zingg HH |title=The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. |journal=J. Mol. Endocrinol. |volume=19 |issue= 2 |pages= 163-72 |year= 1998 |pmid= 9343308 |doi= }}
* {{cite journal | vauthors = Smirnov DA, Hou S, Ricciardi RP | title = Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription | journal = Virology | volume = 268 | issue = 2 | pages = 319–28 | year = 2000 | pmid = 10704340 | doi = 10.1006/viro.1999.0181 }}
*{{cite journal | author=Bailey P, Sartorelli V, Hamamori Y, Muscat GE |title=The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD. |journal=Nucleic Acids Res. |volume=26 |issue= 23 |pages= 5501-10 |year= 1999 |pmid= 9826778 |doi= }}
* {{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22 | year = 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}
*{{cite journal | author=Avram D, Ishmael JE, Nevrivy DJ, ''et al.'' |title=Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14331-6 |year= 1999 |pmid= 10318855 |doi= }}
* {{cite journal | vauthors = Jordan EM, Worley T, Breen GA | title = Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1 | journal = Biochemistry | volume = 42 | issue = 9 | pages = 2656–63 | year = 2003 | pmid = 12614160 | doi = 10.1021/bi0268347 }}
*{{cite journal | author=Smirnov DA, Hou S, Ricciardi RP |title=Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription. |journal=Virology |volume=268 |issue= 2 |pages= 319-28 |year= 2000 |pmid= 10704340 |doi= 10.1006/viro.1999.0181 }}
* {{cite journal | vauthors = Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H | title = Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle | journal = J. Clin. Endocrinol. Metab. | volume = 88 | issue = 7 | pages = 3415–20 | year = 2003 | pmid = 12843196 | doi = 10.1210/jc.2002-021723 }}
*{{cite journal | author=Avram D, Fields A, Pretty On Top K, ''et al.'' |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315-22 |year= 2000 |pmid= 10744719 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional Proteomics Mapping of a Human Signaling Pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kurihara I, Shibata H, Kobayashi S, Suda N, Ikeda Y, Yokota K, Murai A, Saito I, Rainey WE, Saruta T | title = Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription | journal = J. Biol. Chem. | volume = 280 | issue = 8 | pages = 6721–30 | year = 2005 | pmid = 15611122 | doi = 10.1074/jbc.M411820200 }}
*{{cite journal | author=Jordan EM, Worley T, Breen GA |title=Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1. |journal=Biochemistry |volume=42 |issue= 9 |pages= 2656-63 |year= 2003 |pmid= 12614160 |doi= 10.1021/bi0268347 }}
* {{cite journal | vauthors = Shibata H, Kobayashi S, Kurihara I, Suda N, Yokota K, Murai A, Ikeda Y, Saito I, Rainey WE, Saruta T | title = COUP-TF and transcriptional co-regulators in adrenal steroidogenesis | journal = Endocr. Res. | volume = 30 | issue = 4 | pages = 795–801 | year = 2005 | pmid = 15666827 | doi = 10.1081/ERC-200044042 }}
*{{cite journal | author=Sato Y, Suzuki T, Hidaka K, ''et al.'' |title=Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 7 |pages= 3415-20 |year= 2003 |pmid= 12843196 |doi= }}
{{Refend|2}}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
 
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
{{Transcription factors|g2}}
*{{cite journal  | author=Kurihara I, Shibata H, Kobayashi S, ''et al.'' |title=Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription. |journal=J. Biol. Chem. |volume=280 |issue= 8 |pages= 6721-30 |year= 2005 |pmid= 15611122 |doi= 10.1074/jbc.M411820200 }}
*{{cite journal  | author=Shibata H, Kobayashi S, Kurihara I, ''et al.'' |title=COUP-TF and transcriptional co-regulators in adrenal steroidogenesis. |journal=Endocr. Res. |volume=30 |issue= 4 |pages= 795-801 |year= 2005 |pmid= 15666827 |doi=  }}
}}
{{refend}}


{{protein-stub}}
{{Transcription factors}}
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 00:44, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.[1][2] The COUP acronym stands for chicken ovalbumin upstream promoter.

Function

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.[3][4]

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.[5][6] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.[7]

Interactions

COUP-TFII has been shown to interact with:

References

  1. ↑ "Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2".
  2. ↑ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
  3. ↑ Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development". Genes Dev. 13 (8): 1037–49. doi:10.1101/gad.13.8.1037. PMC 316637. PMID 10215630.
  4. ↑ Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (December 2004). "The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development". Mol. Cell. Biol. 24 (24): 10835–43. doi:10.1128/MCB.24.24.10835-10843.2004. PMC 533959. PMID 15572686.
  5. ↑ De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (April 2004). "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism". Mol. Endocrinol. 18 (4): 820–33. doi:10.1210/me.2003-0341. PMID 14739255.
  6. ↑ De Martino MU, Alesci S, Chrousos GP, Kino T (June 2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024: 72–85. doi:10.1196/annals.1321.006. PMID 15265774.
  7. ↑ Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (February 2008). "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis". Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421–6. doi:10.1073/pnas.0707082105. PMC 2268152. PMID 18250317.
  8. ↑ Smirnov DA, Hou S, Ricciardi RP (March 2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology. 268 (2): 319–28. doi:10.1006/viro.1999.0181. PMID 10704340.
  9. ↑ Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (November 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. doi:10.1074/jbc.271.44.27197. PMID 8910285.
  10. ↑ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
  11. ↑ Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM (May 2012). "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells". PLOS ONE. 7 (5): e38278. doi:10.1371/journal.pone.0038278. PMC 3365040. PMID 22693611.

External links

Further reading

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