CEBPG: Difference between revisions

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{{Infobox_gene}}
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'''CCAAT/enhancer-binding protein gamma''' is a [[protein]] that in humans is encoded by the ''CEBPG'' [[gene]].<ref name="pmid1884998">{{cite journal | vauthors = Williams SC, Cantwell CA, Johnson PF | title = A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro | journal = Genes Dev | volume = 5 | issue = 9 | pages = 1553–67 |date=Oct 1991 | pmid = 1884998 | pmc =  | doi =10.1101/gad.5.9.1553 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1054| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = CCAAT/enhancer binding protein (C/EBP), gamma
| HGNCid = 1837
| Symbol = CEBPG
| AltSymbols =; GPE1BP; IG/EBP-1
| OMIM = 138972
| ECnumber = 
| Homologene = 1368
| MGIid = 104982
| GeneAtlas_image1 = PBB_GE_CEBPG_204203_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001889 |text = liver development}} {{GNF_GO|id=GO:0006337 |text = nucleosome disassembly}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0042267 |text = natural killer cell mediated cytotoxicity}} {{GNF_GO|id=GO:0043353 |text = enucleate erythrocyte differentiation}} {{GNF_GO|id=GO:0043388 |text = positive regulation of DNA binding}} {{GNF_GO|id=GO:0043433 |text = negative regulation of transcription factor activity}} {{GNF_GO|id=GO:0045078 |text = positive regulation of interferon-gamma biosynthetic process}} {{GNF_GO|id=GO:0045739 |text = positive regulation of DNA repair}} {{GNF_GO|id=GO:0051091 |text = positive regulation of transcription factor activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1054
    | Hs_Ensembl = ENSG00000153879
    | Hs_RefseqProtein = NP_001797
    | Hs_RefseqmRNA = NM_001806
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 38556449
    | Hs_GenLoc_end = 38565431
    | Hs_Uniprot = P53567
    | Mm_EntrezGene = 12611
    | Mm_Ensembl = ENSMUSG00000056216
    | Mm_RefseqmRNA = NM_009884
    | Mm_RefseqProtein = NP_034014
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 34755537
    | Mm_GenLoc_end = 34765263
    | Mm_Uniprot = Q54AJ1
  }}
}}
'''CCAAT/enhancer binding protein (C/EBP), gamma''', also known as '''CEBPG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1054| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription.  C/EBP proteins  contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other.  CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements.<ref name="entrez">{{cite web | title = Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1054| accessdate = }}</ref>
| summary_text = The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription.  C/EBP proteins  contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other.  CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nishizawa M, Nagata S |title=cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. |journal=FEBS Lett. |volume=299 |issue= 1 |pages= 36-8 |year= 1992 |pmid= 1371974 |doi=  }}
*{{cite journal  | vauthors=Nishizawa M, Nagata S |title=cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. |journal=FEBS Lett. |volume=299 |issue= 1 |pages= 36–8 |year= 1992 |pmid= 1371974 |doi=10.1016/0014-5793(92)80094-W }}
*{{cite journal  | author=Thomassin H, Hamel D, Bernier D, ''et al.'' |title=Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma. |journal=Nucleic Acids Res. |volume=20 |issue= 12 |pages= 3091-8 |year= 1992 |pmid= 1377818 |doi=  }}
*{{cite journal  | vauthors=Thomassin H, Hamel D, Bernier D |title=Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma. |journal=Nucleic Acids Res. |volume=20 |issue= 12 |pages= 3091–8 |year= 1992 |pmid= 1377818 |doi=10.1093/nar/20.12.3091  | pmc=312443 |display-authors=etal}}
*{{cite journal  | author=Nishizawa M, Wakabayashi-Ito N, Nagata S |title=Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1. |journal=FEBS Lett. |volume=282 |issue= 1 |pages= 95-7 |year= 1991 |pmid= 1709121 |doi= }}
*{{cite journal  | vauthors=Nishizawa M, Wakabayashi-Ito N, Nagata S |title=Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1. |journal=FEBS Lett. |volume=282 |issue= 1 |pages= 95–7 |year= 1991 |pmid= 1709121 |doi=10.1016/0014-5793(91)80452-9  }}
*{{cite journal  | author=Williams SC, Cantwell CA, Johnson PF |title=A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. |journal=Genes Dev. |volume=5 |issue= 9 |pages= 1553-67 |year= 1991 |pmid= 1884998 |doi= }}
*{{cite journal  | vauthors=Cooper C, Henderson A, Artandi S |title=Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. |journal=Nucleic Acids Res. |volume=23 |issue= 21 |pages= 4371–7 |year= 1996 |pmid= 7501458 |doi=10.1093/nar/23.21.4371 | pmc=307392  |display-authors=etal}}
*{{cite journal  | author=Cooper C, Henderson A, Artandi S, ''et al.'' |title=Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. |journal=Nucleic Acids Res. |volume=23 |issue= 21 |pages= 4371-7 |year= 1996 |pmid= 7501458 |doi=  }}
*{{cite journal  | vauthors=Davydov IV, Bohmann D, Krammer PH, Li-Weber M |title=Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. |journal=Gene |volume=161 |issue= 2 |pages= 271–5 |year= 1995 |pmid= 7665092 |doi=10.1016/0378-1119(95)00271-7 }}
*{{cite journal  | author=Davydov IV, Bohmann D, Krammer PH, Li-Weber M |title=Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. |journal=Gene |volume=161 |issue= 2 |pages= 271-5 |year= 1995 |pmid= 7665092 |doi=  }}
*{{cite journal  | vauthors=Lundgren M, Larsson C, Femino A |title=Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. |journal=J. Immunol. |volume=153 |issue= 7 |pages= 2983–95 |year= 1994 |pmid= 8089482 |doi=  |display-authors=etal}}
*{{cite journal  | author=Lundgren M, Larsson C, Femino A, ''et al.'' |title=Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. |journal=J. Immunol. |volume=153 |issue= 7 |pages= 2983-95 |year= 1994 |pmid= 8089482 |doi=  }}
*{{cite journal  | vauthors=Martin ML, Lieberman PM, Curran T |title=Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2110–8 |year= 1996 |pmid= 8628277 |doi= | pmc=231198 }}
*{{cite journal  | author=Martin ML, Lieberman PM, Curran T |title=Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2110-8 |year= 1996 |pmid= 8628277 |doi=  }}
*{{cite journal  | vauthors=Gao H, Parkin S, Johnson PF, Schwartz RC |title=C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38827–37 |year= 2002 |pmid= 12177065 |doi= 10.1074/jbc.M206224200 }}
*{{cite journal  | author=Gao H, Parkin S, Johnson PF, Schwartz RC |title=C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38827-37 |year= 2002 |pmid= 12177065 |doi= 10.1074/jbc.M206224200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hattori T, Ohoka N, Inoue Y |title=C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer. |journal=Oncogene |volume=22 |issue= 9 |pages= 1273–80 |year= 2003 |pmid= 12618752 |doi= 10.1038/sj.onc.1206204 |display-authors=etal}}
*{{cite journal  | author=Hattori T, Ohoka N, Inoue Y, ''et al.'' |title=C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer. |journal=Oncogene |volume=22 |issue= 9 |pages= 1273-80 |year= 2003 |pmid= 12618752 |doi= 10.1038/sj.onc.1206204 }}
*{{cite journal  | vauthors=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097–101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648 }}
*{{cite journal  | author=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097-101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Mullins DN, Crawford EL, Khuder SA |title=CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. |journal=BMC Cancer |volume=5|pages= 141 |year= 2006 |pmid= 16255782 |doi= 10.1186/1471-2407-5-141 | pmc=1310620 |display-authors=etal}}
*{{cite journal  | author=Mullins DN, Crawford EL, Khuder SA, ''et al.'' |title=CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma. |journal=BMC Cancer |volume=5 |issue=  |pages= 141 |year= 2006 |pmid= 16255782 |doi= 10.1186/1471-2407-5-141 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CEBPG+protein,+human}}
* {{MeshName|CEBPG+protein,+human}}
* {{UCSC gene info|CEBPG}}


{{NLM content}}
{{NLM content}}
{{Transcription factors|g1}}
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[[Category:Transcription factors]]
{{gene-19-stub}}
{{gene-19-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 09:31, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene.[1][2]

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements.[2]

See also

References

  1. ↑ Williams SC, Cantwell CA, Johnson PF (Oct 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
  2. ↑ 2.0 2.1 "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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