CEBPB

CCAAT/enhancer binding protein (C/EBP), beta
File:PBB Protein CEBPB image.jpg PDB rendering based on 1ci6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ci6​, 1gtw​, 1gu4​, 1gu5​, 1h88​, 1h89​, 1h8a​, 1hjb​, 1io4​
Identifiers
Symbols	CEBPB ; C/EBP-beta; CRP2; IL6DBP; LAP; MGC32080; NF-IL6; TCF5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3807
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CCAAT/enhancer binding protein (C/EBP), beta, also known as CEBPB, is a human gene.

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.

See also

• Ccaat-enhancer-binding proteins

Further reading

• Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression". Curr. Opin. Genet. Dev. 2 (2): 256–9. PMID 1638120.
• Maytin EV, Habener JF (1998). "Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo". J. Invest. Dermatol. 110 (3): 238–46. doi:10.1046/j.1523-1747.1998.00123.x. PMID 9506442.
• Cornwall GA, Hsia N (2003). "[Cres (cystatin-related epididymal spermatogenic) gene regulation and function]". Zhonghua Nan Ke Xue. 8 (5): 313–8. PMID 12479114.

External links

• CEBPB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.