CDX1

Caudal type homeobox transcription factor 1
Identifiers
Symbols	CDX1 ; MGC116915
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1366
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Caudal type homeobox transcription factor 1, also known as CDX1, is a human gene.

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.

Further reading

• Bonner CA, Loftus SK, Wasmuth JJ (1996). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics. 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027.CS1 maint: Multiple names: authors list (link)
• "Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group". Nat. Genet. 12 (2): 130–6. 1996. doi:10.1038/ng0296-130. PMID 8563749.
• Mallo GV, Rechreche H, Frigerio JM; et al. (1997). "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis". Int. J. Cancer. 74 (1): 35–44. PMID 9036867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizoshita T, Inada K, Tsukamoto T; et al. (2002). "Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach". Gastric Cancer. 4 (4): 185–91. PMID 11846061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suh ER, Ha CS, Rankin EB; et al. (2002). "DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". J. Biol. Chem. 277 (39): 35795–800. doi:10.1074/jbc.M205567200. PMID 12124393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Domon-Dell C, Schneider A, Moucadel V; et al. (2003). "Cdx1 homeobox gene during human colon cancer progression". Oncogene. 22 (39): 7913–21. doi:10.1038/sj.onc.1206756. PMID 12970739.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong NA, Britton MP, Choi GS; et al. (2004). "Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 574–9. doi:10.1073/pnas.0307190101. PMID 14704280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rankin EB, Xu W, Silberg DG, Suh E (2004). "Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (5): G872–80. doi:10.1152/ajpgi.00326.2003. PMID 14715525.CS1 maint: Multiple names: authors list (link)
• Béland M, Pilon N, Houle M; et al. (2004). "Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex". Mol. Cell. Biol. 24 (11): 5028–38. doi:10.1128/MCB.24.11.5028-5038.2004. PMID 15143193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo RJ, Huang E, Ezaki T; et al. (2004). "Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity". J. Biol. Chem. 279 (35): 36865–75. doi:10.1074/jbc.M405213200. PMID 15215241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alkhoury F, Malo MS, Mozumder M; et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong NA, Wilding J, Bartlett S; et al. (2005). "CDX1 is an important molecular mediator of Barrett's metaplasia". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7565–70. doi:10.1073/pnas.0502031102. PMID 15894614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CDX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.