BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)
Identifiers
Symbols	BCL11B ; RIT1; CTIP-2; CTIP2; hRIT1-alpha
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10974
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

B-cell CLL/lymphoma 11B (zinc finger protein), also known as BCL11B, is a human gene.

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.

Further reading

• Avram D, Fields A, Pretty On Top K; et al. (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. PMID 10744719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satterwhite E, Sonoki T, Willis TG; et al. (2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood. 98 (12): 3413–20. PMID 11719382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Avram D, Fields A, Senawong T; et al. (2003). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein". Biochem. J. 368 (Pt 2): 555–63. doi:10.1042/BJ20020496. PMID 12196208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wakabayashi Y, Inoue J, Takahashi Y; et al. (2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas". Biochem. Biophys. Res. Commun. 301 (2): 598–603. PMID 12565905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rohr O, Lecestre D, Chasserot-Golaz S; et al. (2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells". J. Virol. 77 (9): 5415–27. PMID 12692243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Senawong T, Peterson VJ, Avram D; et al. (2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression". J. Biol. Chem. 278 (44): 43041–50. doi:10.1074/jbc.M307477200. PMID 12930829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bezrookove V, van Zelderen-Bhola SL, Brink A; et al. (2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene". Cancer Genet. Cytogenet. 149 (1): 72–6. PMID 15104287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• MacLeod RA, Nagel S, Drexler HG (2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia". Cancer Genet. Cytogenet. 153 (1): 88–9. doi:10.1016/j.cancergencyto.2004.02.020. PMID 15325104.CS1 maint: Multiple names: authors list (link)
• Przybylski GK, Dik WA, Wanzeck J; et al. (2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL". Leukemia. 19 (2): 201–8. doi:10.1038/sj.leu.2403619. PMID 15668700.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cismasiu VB, Adamo K, Gecewicz J; et al. (2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter". Oncogene. 24 (45): 6753–64. doi:10.1038/sj.onc.1208904. PMID 16091750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Topark-Ngarm A, Golonzhka O, Peterson VJ; et al. (2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". J. Biol. Chem. 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMID 16950772.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marban C, Suzanne S, Dequiedt F; et al. (2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing". EMBO J. 26 (2): 412–23. doi:10.1038/sj.emboj.7601516. PMID 17245431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagel S, Scherr M, Kel A; et al. (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. 67 (4): 1461–71. doi:10.1158/0008-5472.CAN-06-2615. PMID 17308084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamimura K, Mishima Y, Obata M; et al. (2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages". Oncogene. 26 (40): 5840–50. doi:10.1038/sj.onc.1210388. PMID 17369851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• BCL11B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.