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{{Infobox_gene}}
{{PBB_Controls
'''Adenylyl cyclase type 9''' is an [[enzyme]] that in humans is encoded by the ''ADCY9'' [[gene]].<ref name="pmid9628827">{{cite journal | vauthors = Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR | title = Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9) | journal = Genomics | volume = 50 | issue = 1 | pages = 97–104 |date=Apr 1999| pmid = 9628827 | pmc = | doi = 10.1006/geno.1998.5293 }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adenylate cyclase 9
| HGNCid = 240
| Symbol = ADCY9
| AltSymbols =;
| OMIM = 603302
| ECnumber = 
| Homologene = 868
| MGIid = 108450
| GeneAtlas_image1 = PBB_GE_ADCY9_204497_at_tn.png
| GeneAtlas_image2 = PBB_GE_ADCY9_204498_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004016 |text = adenylate cyclase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 115
    | Hs_Ensembl = ENSG00000162104
    | Hs_RefseqProtein = NP_001107
    | Hs_RefseqmRNA = NM_001116
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 3952658
    | Hs_GenLoc_end = 4106187
    | Hs_Uniprot = O60503
    | Mm_EntrezGene = 11515
    | Mm_Ensembl = ENSMUSG00000005580
    | Mm_RefseqmRNA = NM_009624
    | Mm_RefseqProtein = NP_033754
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 4202773
    | Mm_GenLoc_end = 4335034
    | Mm_Uniprot = Q3UWC8
  }}
}}
'''Adenylate cyclase 9''', also known as '''ADCY9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY9 adenylate cyclase 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Adenylyl cyclase]] is a membrane bound enzyme that catalyses the formation of [[cyclic AMP]] from [[adenosine triphosphate|ATP]]. It is regulated by a family of [[G protein-coupled receptor]]s, [[protein kinase]]s, and [[calcium in biology|calcium]]. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by [[beta-adrenergic receptor]] activation but is insensitive to [[forskolin]], calcium, and [[somatostatin]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY9 adenylate cyclase 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.<ref name="entrez">{{cite web | title = Entrez Gene: ADCY9 adenylate cyclase 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ADCY9}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Paterson JM, Smith SM, Harmar AJ, Antoni FA |title=Control of a novel adenylyl cyclase by calcineurin. |journal=Biochem. Biophys. Res. Commun. |volume=214 |issue= 3 |pages= 1000–8 |year= 1995 |pmid= 7575502 |doi= 10.1006/bbrc.1995.2385 }}
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | vauthors=Premont RT, Matsuoka I, Mattei MG |title=Identification and characterization of a widely expressed form of adenylyl cyclase. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13900–7 |year= 1996 |pmid= 8662814 |doi=10.1074/jbc.271.23.13900 |display-authors=etal}}
*{{cite journal  | author=Paterson JM, Smith SM, Harmar AJ, Antoni FA |title=Control of a novel adenylyl cyclase by calcineurin. |journal=Biochem. Biophys. Res. Commun. |volume=214 |issue= 3 |pages= 1000-8 |year= 1995 |pmid= 7575502 |doi= 10.1006/bbrc.1995.2385 }}
*{{cite journal  | vauthors=Nagase T, Ishikawa K, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31  |display-authors=etal}}
*{{cite journal  | author=Premont RT, Matsuoka I, Mattei MG, ''et al.'' |title=Identification and characterization of a widely expressed form of adenylyl cyclase. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13900-7 |year= 1996 |pmid= 8662814 |doi=  }}
*{{cite journal  | vauthors=Barcova M, Speth C, Kacani L |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflügers Arch. |volume=437 |issue= 4 |pages= 538–46 |year= 1999 |pmid= 10089566 |doi=10.1007/s004240050815 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
*{{cite journal  | vauthors=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629–36 |year= 2000 |pmid= 10807185 |doi=10.1097/00002030-200004140-00001 }}
*{{cite journal  | author=Hacker BM, Tomlinson JE, Wayman GA, ''et al.'' |title=Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). |journal=Genomics |volume=50 |issue= 1 |pages= 97-104 |year= 1999 |pmid= 9628827 |doi= 10.1006/geno.1998.5293 }}
*{{cite journal  | vauthors=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975–82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
*{{cite journal  | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi=  }}
*{{cite journal  | vauthors=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399–407 |year= 2001 |pmid= 11299302 |doi=10.1046/j.1471-4159.2001.00249.x }}
*{{cite journal  | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi=  }}
*{{cite journal  | vauthors=Toyota T, Hattori E, Meerabux J |title=Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 84–92 |year= 2002 |pmid= 11840511 |doi=10.1002/ajmg.10117 |display-authors=etal}}
*{{cite journal  | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
*{{cite journal  | vauthors=Speth C, Schabetsberger T, Mohsenipour I |title=Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179–88 |year= 2002 |pmid= 11884542 |doi=10.1128/JVI.76.7.3179-3188.2002  | pmc=136041 |display-authors=etal}}
*{{cite journal  | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi=  }}
*{{cite journal  | vauthors=Toyota T, Yamada K, Saito K |title=Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 450–2 |year= 2002 |pmid= 12082561 |doi= 10.1038/sj.mp.4000992 |display-authors=etal}}
*{{cite journal  | author=Toyota T, Hattori E, Meerabux J, ''et al.'' |title=Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. |journal=Am. J. Med. Genet. |volume=114 |issue= 1 |pages= 84-92 |year= 2002 |pmid= 11840511 |doi=  }}
*{{cite journal  | vauthors=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1–4 |pages= 79–110 |year= 2003 |pmid= 12503609 |doi=10.1081/RRS-120014589 }}
*{{cite journal  | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi=  }}
*{{cite journal  | vauthors=Small KM, Brown KM, Theiss CT |title=An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation |journal=Pharmacogenetics |volume=13 |issue= 9 |pages= 535–41 |year= 2004 |pmid= 12972952 |doi= 10.1097/00008571-200309000-00002 |display-authors=etal}}
*{{cite journal  | author=Toyota T, Yamada K, Saito K, ''et al.'' |title=Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder. |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 450-2 |year= 2002 |pmid= 12082561 |doi= 10.1038/sj.mp.4000992 }}
*{{cite journal  | vauthors=Cumbay MG, Watts VJ |title=Novel regulatory properties of human type 9 adenylate cyclase |journal=J. Pharmacol. Exp. Ther. |volume=310 |issue= 1 |pages= 108–15 |year= 2004 |pmid= 14996950 |doi= 10.1124/jpet.104.065748 }}
*{{cite journal  | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79-110 |year= 2003 |pmid= 12503609 |doi=  }}
*{{cite journal  | vauthors=Tantisira KG, Small KM, Litonjua AA |title=Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways |journal=Hum. Mol. Genet. |volume=14 |issue= 12 |pages= 1671–7 |year= 2005 |pmid= 15879435 |doi= 10.1093/hmg/ddi175 |display-authors=etal}}
*{{cite journal  | author=Small KM, Brown KM, Theiss CT, ''et al.'' |title=An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. |journal=Pharmacogenetics |volume=13 |issue= 9 |pages= 535-41 |year= 2004 |pmid= 12972952 |doi= 10.1097/01.fpc.0000054119.14659.01 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Cumbay MG, Watts VJ |title=Novel regulatory properties of human type 9 adenylate cyclase. |journal=J. Pharmacol. Exp. Ther. |volume=310 |issue= 1 |pages= 108-15 |year= 2004 |pmid= 14996950 |doi= 10.1124/jpet.104.065748 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Tantisira KG, Small KM, Litonjua AA, ''et al.'' |title=Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. |journal=Hum. Mol. Genet. |volume=14 |issue= 12 |pages= 1671-7 |year= 2005 |pmid= 15879435 |doi= 10.1093/hmg/ddi175 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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[[Category:Biology of bipolar disorder]]
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Latest revision as of 09:19, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adenylyl cyclase type 9 is an enzyme that in humans is encoded by the ADCY9 gene.[1][2]

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.[2]

References

  1. ↑ Hacker BM, Tomlinson JE, Wayman GA, Sultana R, Chan G, Villacres E, Disteche C, Storm DR (Apr 1999). "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9)". Genomics. 50 (1): 97–104. doi:10.1006/geno.1998.5293. PMID 9628827.
  2. ↑ 2.0 2.1 "Entrez Gene: ADCY9 adenylate cyclase 9".

External links

Further reading


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