Cytidylate cyclase

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In enzymology, a cytidylate cyclase (EC is an enzyme that catalyzes the chemical reaction

CTP 3',5'-cyclic CMP + diphosphate

Hence, this enzyme has one substrate, CTP, and two products, 3',5'-cyclic CMP and diphosphate.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming). Other names in common use include 3',5'-cyclic-CMP synthase, cytidylyl cyclase, cytidyl cyclase, and CTP diphosphate-lyase (cyclizing).


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Cech SY, Ignarro LJ (1978). "Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver". Biochem. Biophys. Res. Commun. 80: 119&ndash, 25. PMID 23778.
  • JH (1985). "3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian-tissues". Biochem. Soc. Trans. 13: 1134&ndash, 1135.

External links

The CAS registry number for this enzyme class is 65357-82-6.

Gene Ontology (GO) codes