2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP
Hence, this enzyme has one substrate, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and two products, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.
This enzyme belongs to the family of lyases, specifically phosphorus-oxygen lyases. The systematic name of this enzyme class is 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming). Other names in common use include MECDP-synthase, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and CMP-lyase (cyclizing). This enzyme participates in biosynthesis of steroids.
As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes 1GX1, 1H47, 1H48, 1IV1, 1IV2, 1IV3, 1IV4, 1T0A, 1U3L, 1U3P, 1U40, 1U43, 1VH8, 1VHA, 1W55, 1W57, 1YQN, 2AMT, 2GZL, and 2PMP.
- IUBMB entry for 18.104.22.168
- BRENDA references for 22.214.171.124 (Recommended.)
- PubMed references for 126.96.36.199
- PubMed Central references for 188.8.131.52
- Google Scholar references for 184.108.40.206
- Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F (2000). "Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate". Proc. Natl. Acad. Sci. U. S. A. 97: 2486&ndash, 90. PMID 10694574.
- Seto H (2000). "Studies on the nonmevalonate pathway: Formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol". Tetrahedron Lett. 41: 3395&ndash, 3398.
Gene Ontology (GO) codes
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