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{{Infobox_gene}}
{{PBB_Controls
'''Adenylyl cyclase type 8''' is an [[enzyme]] that in humans is encoded by the ''ADCY8'' [[gene]].<ref name="pmid8076676">{{cite journal | vauthors = Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J | title = Molecular cloning of the human type VIII adenylyl cyclase | journal = FEBS Letters | volume = 351 | issue = 1 | pages = 109–13 | date = Aug 1994 | pmid = 8076676 | pmc =  | doi = 10.1016/0014-5793(94)00836-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADCY8 adenylate cyclase 8 (brain)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adenylate cyclase 8 (brain)
| HGNCid = 239
| Symbol = ADCY8
| AltSymbols =; ADCY3; HBAC1
| OMIM = 103070
| ECnumber = 
| Homologene = 37443
| MGIid = 1341110
| GeneAtlas_image1 = PBB_GE_ADCY8_206811_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004016 |text = adenylate cyclase activity}} {{GNF_GO|id=GO:0008294 |text = calcium- and calmodulin-responsive adenylate cyclase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0009190 |text = cyclic nucleotide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114
    | Hs_Ensembl = ENSG00000155897
    | Hs_RefseqProtein = NP_001106
    | Hs_RefseqmRNA = NM_001115
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 131861736
    | Hs_GenLoc_end = 132123854
    | Hs_Uniprot = P40145
    | Mm_EntrezGene = 11514
    | Mm_Ensembl = ENSMUSG00000022376
    | Mm_RefseqmRNA = NM_009623
    | Mm_RefseqProtein = NP_033753
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 64528707
    | Mm_GenLoc_end = 64751833
    | Mm_Uniprot = P97490
  }}
}}
'''Adenylate cyclase 8 (brain)''', also known as '''ADCY8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADCY8 adenylate cyclase 8 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Adenylyl cyclase]] is a membrane bound enzyme that catalyses the formation of [[cyclic AMP]] from [[adenosine triphosphate|ATP]]. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (R<sub>s</sub> and R<sub>i</sub>) interact with [[G protein]]s (G<sub>s</sub> and G<sub>i</sub>) that exhibit [[GTPase]] activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase<ref name="entrez">{{cite web | title = Entrez Gene: ADCY8 adenylate cyclase 8 (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
==External links==
* {{UCSC gene info|ADCY3}}
* {{UCSC gene info|ADCY8}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Stengel D, Parma J, Gannagé MH, Roeckel N, Mattei MG, Barouki R, Hanoune J | title = Different chromosomal localization of two adenylyl cyclase genes expressed in human brain | journal = Human Genetics | volume = 90 | issue = 1-2 | pages = 126–30 | year = 1992 | pmid = 1427768 | doi = 10.1007/BF00210755 }}
| citations =
* {{cite journal | vauthors = Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J | title = Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain | journal = Biochemical and Biophysical Research Communications | volume = 179 | issue = 1 | pages = 455–62 | date = Aug 1991 | pmid = 1715695 | doi = 10.1016/0006-291X(91)91392-P }}
*{{cite journal | author=Stengel D, Parma J, Gannagé MH, ''et al.'' |title=Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. |journal=Hum. Genet. |volume=90 |issue= 1-2 |pages= 126-30 |year= 1992 |pmid= 1427768 |doi= }}
* {{cite journal | vauthors = Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J | title = Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain | journal = The Journal of Biological Chemistry | volume = 269 | issue = 16 | pages = 12190–5 | date = Apr 1994 | pmid = 8163524 | doi =  }}
*{{cite journal | author=Parma J, Stengel D, Gannage MH, ''et al.'' |title=Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. |journal=Biochem. Biophys. Res. Commun. |volume=179 |issue= 1 |pages= 455-62 |year= 1991 |pmid= 1715695 |doi= }}
* {{cite journal | vauthors = Gu C, Cooper DM | title = Calmodulin-binding sites on adenylyl cyclase type VIII | journal = The Journal of Biological Chemistry | volume = 274 | issue = 12 | pages = 8012–21 | date = Mar 1999 | pmid = 10075700 | doi = 10.1074/jbc.274.12.8012 }}
*{{cite journal  | author=Defer N, Marinx O, Stengel D, ''et al.'' |title=Molecular cloning of the human type VIII adenylyl cyclase. |journal=FEBS Lett. |volume=351 |issue= 1 |pages= 109-13 |year= 1994 |pmid= 8076676 |doi=  }}
* {{cite journal | vauthors = Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP | title = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 | journal = Pflügers Archiv | volume = 437 | issue = 4 | pages = 538–46 | date = Mar 1999 | pmid = 10089566 | doi = 10.1007/s004240050815 }}
*{{cite journal | author=Cali JJ, Zwaagstra JC, Mons N, ''et al.'' |title=Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12190-5 |year= 1994 |pmid= 8163524 |doi=  }}
* {{cite journal | vauthors = Speth C, Joebstl B, Barcova M, Dierich MP | title = HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones | journal = AIDS | volume = 14 | issue = 6 | pages = 629–36 | date = Apr 2000 | pmid = 10807185 | doi = 10.1097/00002030-200004140-00001 }}
*{{cite journal | author=Gu C, Cooper DM |title=Calmodulin-binding sites on adenylyl cyclase type VIII. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 8012-21 |year= 1999 |pmid= 10075700 |doi= }}
* {{cite journal | vauthors = Patke CL, Shearer WT | title = gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression | journal = The Journal of Allergy and Clinical Immunology | volume = 105 | issue = 5 | pages = 975–82 | date = May 2000 | pmid = 10808179 | doi = 10.1067/mai.2000.105315 }}
*{{cite journal | author=Barcova M, Speth C, Kacani L, ''et al.'' |title=Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. |journal=Pflugers Arch. |volume=437 |issue= 4 |pages= 538-46 |year= 1999 |pmid= 10089566 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Speth C, Joebstl B, Barcova M, Dierich MP |title=HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. |journal=AIDS |volume=14 |issue= 6 |pages= 629-36 |year= 2000 |pmid= 10807185 |doi= }}
* {{cite journal | vauthors = Patrizio M, Colucci M, Levi G | title = Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures | journal = Journal of Neurochemistry | volume = 77 | issue = 2 | pages = 399–407 | date = Apr 2001 | pmid = 11299302 | doi = 10.1046/j.1471-4159.2001.00249.x }}
*{{cite journal | author=Patke CL, Shearer WT |title=gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 5 |pages= 975-82 |year= 2000 |pmid= 10808179 |doi= 10.1067/mai.2000.105315 }}
* {{cite journal | vauthors = Parkinson NA, Bolsover SR | title = A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones | journal = Brain Research. Molecular Brain Research | volume = 91 | issue = 1-2 | pages = 43–9 | date = Jul 2001 | pmid = 11457491 | doi = 10.1016/S0169-328X(01)00119-X }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP | title = Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons | journal = Journal of Virology | volume = 76 | issue = 7 | pages = 3179–88 | date = Apr 2002 | pmid = 11884542 | pmc = 136041 | doi = 10.1128/JVI.76.7.3179-3188.2002 }}
*{{cite journal | author=Patrizio M, Colucci M, Levi G |title=Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. |journal=J. Neurochem. |volume=77 |issue= 2 |pages= 399-407 |year= 2001 |pmid= 11299302 |doi= }}
* {{cite journal | vauthors = Ludwig MG, Seuwen K | title = Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms | journal = Journal of Receptor and Signal Transduction Research | volume = 22 | issue = 1-4 | pages = 79–110 | year = 2003 | pmid = 12503609 | doi = 10.1081/RRS-120014589 }}
*{{cite journal | author=Parkinson NA, Bolsover SR |title=A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones. |journal=Brain Res. Mol. Brain Res. |volume=91 |issue= 1-2 |pages= 43-9 |year= 2001 |pmid= 11457491 |doi= }}
* {{cite journal | vauthors = Georget M, Mateo P, Vandecasteele G, Lipskaia L, Defer N, Hanoune J, Hoerter J, Lugnier C, Fischmeister R | title = Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8) | journal = FASEB Journal | volume = 17 | issue = 11 | pages = 1380–91 | date = Aug 2003 | pmid = 12890691 | doi = 10.1096/fj.02-0784com }}
*{{cite journal | author=Speth C, Schabetsberger T, Mohsenipour I, ''et al.'' |title=Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. |journal=J. Virol. |volume=76 |issue= 7 |pages= 3179-88 |year= 2002 |pmid= 11884542 |doi= }}
* {{cite journal | vauthors = Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM | title = A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A | journal = Molecular Pharmacology | volume = 69 | issue = 2 | pages = 608–17 | date = Feb 2006 | pmid = 16258073 | doi = 10.1124/mol.105.018275 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Simpson RE, Ciruela A, Cooper DM | title = The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 25 | pages = 17379–89 | date = Jun 2006 | pmid = 16613843 | doi = 10.1074/jbc.M510992200 }}
*{{cite journal | author=Ludwig MG, Seuwen K |title=Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. |journal=J. Recept. Signal Transduct. Res. |volume=22 |issue= 1-4 |pages= 79-110 |year= 2003 |pmid= 12503609 |doi= }}
* {{cite journal | vauthors = Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M | title = Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia | journal = FEBS Letters | volume = 581 | issue = 17 | pages = 3241–6 | date = Jul 2007 | pmid = 17586501 | pmc = 1986749 | doi = 10.1016/j.febslet.2007.06.015 }}
*{{cite journal | author=Georget M, Mateo P, Vandecasteele G, ''et al.'' |title=Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8). |journal=FASEB J. |volume=17 |issue= 11 |pages= 1380-91 |year= 2003 |pmid= 12890691 |doi= 10.1096/fj.02-0784com }}
*{{cite journal | author=Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM |title=A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. |journal=Mol. Pharmacol. |volume=69 |issue= 2 |pages= 608-17 |year= 2006 |pmid= 16258073 |doi= 10.1124/mol.105.018275 }}
*{{cite journal | author=Simpson RE, Ciruela A, Cooper DM |title=The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8. |journal=J. Biol. Chem. |volume=281 |issue= 25 |pages= 17379-89 |year= 2006 |pmid= 16613843 |doi= 10.1074/jbc.M510992200 }}
*{{cite journal | author=Nlend MC, Schmid A, Sutto Z, ''et al.'' |title=Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. |journal=FEBS Lett. |volume=581 |issue= 17 |pages= 3241-6 |year= 2007 |pmid= 17586501 |doi= 10.1016/j.febslet.2007.06.015 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 17:50, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[1][2]

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[2]

References

  1. ↑ Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676.
  2. ↑ 2.0 2.1 "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".

External links

Further reading


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