ELK3

ELK3, ETS-domain protein (SRF accessory protein 2)
Identifiers
Symbols	ELK3 ; ERP; NET; SAP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3833
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ELK3, ETS-domain protein (SRF accessory protein 2), also known as ELK3, is a human gene.

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.

Further reading

• Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. PMID 9570133.CS1 maint: Multiple names: authors list (link)
• Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. PMID 9644975.CS1 maint: Multiple names: authors list (link)
• Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. PMID 7540136.CS1 maint: Multiple names: authors list (link)
• Shipley J, Sheer D, Dalton S; et al. (1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giovane A, Pintzas A, Maira SM; et al. (1994). "Net, a new ets transcription factor that is activated by Ras". Genes Dev. 8 (13): 1502–13. PMID 7958835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maira SM, Wurtz JM, Wasylyk B (1997). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. 15 (21): 5849–65. PMID 8918463.CS1 maint: Multiple names: authors list (link)
• Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation". EMBO J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMID 10369679.CS1 maint: Multiple names: authors list (link)
• Ducret C, Maira SM, Dierich A, Wasylyk B (2000). "The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock". Mol. Cell. Biol. 19 (10): 7076–87. PMID 10490644.CS1 maint: Multiple names: authors list (link)
• Ducret C, Maira SM, Lutz Y, Wasylyk B (2000). "The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades". Oncogene. 19 (44): 5063–72. doi:10.1038/sj.onc.1203892. PMID 11042694.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta M, Sueblinvong V, Raman J; et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wasylyk C, Criqui-Filipe P, Wasylyk B (2005). "Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net". Oncogene. 24 (5): 820–8. doi:10.1038/sj.onc.1208226. PMID 15580297.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ELK3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.