Celiac disease overview
Title |
https://https://www.youtube.com/watch?v=nXzBApAx5lY%7C350}} |
Celiac disease Microchapters |
Diagnosis |
---|
Treatment |
Medical Therapy |
Case Studies |
Celiac disease overview On the Web |
American Roentgen Ray Society Images of Celiac disease overview |
Risk calculators and risk factors for Celiac disease overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
American Gastroenterological Association (AGA) Definition: “Chronic malabsorptive disorder of the small intestine caused by exposure to dietary gluten in genetically predisposed individuals”
Celiac disease is an autoimmune disorder of the small bowel that occurs in genetically predisposed people of all ages from middle infancy. Symptoms include chronic diarrhoea, failure to thrive (in children) and fatigue, but these may be absent and symptoms in all other organ systems have been described. It is estimated to affect about 1% of Indo-European populations, although significantly underdiagnosed. A growing portion of diagnoses are being made in asymptomatic persons as a result of increasing screening.[1]
Historical Perspective
500 to 1000 per 100,000 individuals worldwide. The incidence of celiac disease is approximately 10-13 per 100,000 individuals worldwide. Celiac disease affects children and adults alike. Celiac disease usually affects individuals of the non-Hispanic whites (1000 per 100,000 individuals), Hispanics (300 per 100,000 individuals) and non-Hispanic blacks (200 per 100,000 individuals). Like other autoimmune disorders, women are more commonly affected by celiac disease than men. In Africa, Algerian refugees have the highest number of prevalence rate at 5600 per 100,000 individuals.
Classification
Pathophysiology
Causes
Differentiating Celiac Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT Scan
Echocardiography or Ultrasound
Other Imaging Findings
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Future or Investigational Therapies
References
- ↑ van Heel D, West J (2006). "Recent advances in coeliac disease". Gut. 55 (7): 1037–46. PMID 16766754.