Squamous cell carcinoma of the skin: Difference between revisions

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==[[Squamous cell carcinoma physical examination|Physical Examination]]==
==[[Squamous cell carcinoma physical examination|Physical Examination]]==
==== Ear Nose and Throat ====
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Image:Squamous cell carcinoma oral 001.jpg|Squamous cell carcinoma in oral cavity. <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>
Image:Squamous cell carcinoma oral 002.jpg|Squamous cell carcinoma in oral cavity. <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>
Image:Squamous cell carcinoma oral 003.jpg|Squamous cell carcinoma in oral cavity. <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>
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Image:squamous cell skin cancer.jpg|Squamous cell skin cancer.<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages</ref>
Image:Squamous_cell_carcinoma.jpg|A large squamous cell carcinoma of the tongue<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages</ref>
Image:AuricleMelanoma SqCC.jpg|This patient had two adjacent cancers.  The flat black lesion below the antitragus is a malignant melanoma.  The white elevated keratotic lesion is a squamous cell carcinoma <ref>http://www.ghorayeb.com</ref>.
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Image:Head oral scc.jpg|Squamous Cell Cancer of the Mouth: Irregular, necrotic appearing tissue  on the inside of the mouth due to extensive squamous cell cancer. Patient has limited ability to open  his mouth (aka trismus) as a result of the infiltrating cancer.
Image:head_oral_scc1.jpg|Squamous Cell Cancer, Base of Tongue: Note white area with swelling, right  base of tongue.
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Image:Head_oral_scc2.jpg|Squamous Cell Cancer of the Mouth: Cancer that began along the lower gum  line has spread to left submandibular lymph nodes.
Image:Head_oral_scc3.jpg|Squamous Cell Cancer of the Mouth: Cancer that began along the lower gum  line has spread to left submandibular lymph nodes.
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Image:Auriclesqccastellateexcision.jpg|Recurrent squamous cell carcinoma of the auricle (far left) excised with a stellate incision across the antihelix<ref>http://www.ghorayeb.com</ref>.
Image:Auricle003.jpg|The final result of the excision<ref>http://www.ghorayeb.com</ref>.
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===Esophagus===
===Esophagus===

Revision as of 20:04, 16 June 2012

For patient information click here

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Squamous cell carcinoma of the skin Microchapters

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Overview

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Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

Historical Aspects

Pathophysiology

Epidemiology and Demographics

Risk Factors

Screening

Causes of Squamous cell carcinoma

Differential Diagnosis

Natural History Complications and Prognosis

History & Symptoms

Physical Examination

Esophagus

Esophageal cancer may be due to either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC). SCCs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach. Dysphagia (difficulty swallowing, solids worse than liquids) and odynophagia are common initial symptoms. If the disease is localized, esophagectomy may offer the possibility of a cure. If the disease has spread, chemotherapy and radiotherapy are commonly used.

Penis

When squamous cell carcinoma in situ (Bowen's disease) is found on the penis, it is called erythroplasia of Queyrat[1]. This type of cancer respond very well to an experimental agent called Aldara.

Prostate

When associated with the prostate, squamous cell carcinoma is very aggressive in nature. It is difficult to detect as there is no increase in prostate specific antigen levels seen; meaning that the cancer is often diagnosed at an advanced stage.

  • Prostate: Squamous cell carcinoma

    Prostate: Squamous cell carcinoma

  • Prostate: Squamous cell carcinoma

    Prostate: Squamous cell carcinoma

Lung

When associated with the lung, it often causes ectopic production of parathyroid hormone-related protein (PTHrP), resulting in hypercalcemia.

  • Biopsy of a highly differentiated squamous cell carcinoma of the mouth. Haematoxylin & eosin stain.

    Biopsy of a highly differentiated squamous cell carcinoma of the mouth. Haematoxylin & eosin stain.

  • Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus

    Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus

Vagina and cervix

Vaginal squamous cell carcinoma spreads slowly and usually stays near the vagina, but may spread to the lungs and liver. This is the most common type of vaginal cancer.

Cervix: Squamous cell carcinoma

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Staging

Treatment

Future and Investigational treatment strategies

In 2007, Australian biopharmaceutical company Clinuvel Pharmaceuticals Limited began clinical trials with a melanocyte-stimulating hormone called melanotan (known by the International Nonproprietary Name afamelanotide, formerly CUV1647)[2] to provide photoprotection for organ transplant patients against squamous cell carcinoma of the skin and actinic keratosis.[3][4]

Cetuximab a monoclonal antibody that targets the epidermal growth factor receptor (EGFR), has antitumor activity in patients with advanced squamous cell carcinoma of the skin, as initially suggested by case reports.

References

  1. ↑ http://www.emedicine.com/derm/TOPIC144.HTM
  2. ↑ "World Health Organisation assigns CUV1647 generic name" (PDF). Clinuvel. 2008. Retrieved 2008-06-17.
  3. ↑ Clinuvel » Investors » FAQs
  4. ↑ PharmaAsia - Clinuvel’s Drug Begins Global Phase II Skin Cancer Trials

External links


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