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| ==Differential Diagnosis== | | ==Differential Diagnosis== |
| [[Autoimmune hepatitis]] must be differentiated from other diseases that cause [[jaundice]], [[nausea and vomiting]], [[abdominal pain]], arthragia, and [[hepatomegaly]] such as [[Hepatitis]] A,B,C, E, drug induced hepatitis, [[Cytomegalovirus infection|CMV]] hepatitis, [[EBV]] hepatitis, [[alcoholic hepatitis]], [[Primary biliary cirrhosis]] and [[Primary sclerosing cholangitis]].<ref name="pmid21529926">{{cite journal |vauthors=Selmi C, Bowlus CL, Gershwin ME, Coppel RL |title=Primary biliary cirrhosis |journal=Lancet |volume=377 |issue=9777 |pages=1600–9 |year=2011 |pmid=21529926 |doi=10.1016/S0140-6736(10)61965-4 |url=}}</ref><ref name="pmid19554543">{{cite journal |vauthors=Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ |title=Primary biliary cirrhosis |journal=Hepatology |volume=50 |issue=1 |pages=291–308 |year=2009 |pmid=19554543 |doi=10.1002/hep.22906 |url=}}</ref><ref name="pmid9620732">{{cite journal |vauthors=Koff RS |title=Hepatitis A |journal=Lancet |volume=351 |issue=9116 |pages=1643–9 |year=1998 |pmid=9620732 |doi=10.1016/S0140-6736(98)01304-X |url=}}</ref><ref name="pmid10683554">{{cite journal |vauthors=Ciocca M |title=Clinical course and consequences of hepatitis A infection |journal=Vaccine |volume=18 Suppl 1 |issue= |pages=S71–4 |year=2000 |pmid=10683554 |doi= |url=}}</ref><ref name="pmid28145671">{{cite journal |vauthors=Fargo MV, Grogan SP, Saguil A |title=Evaluation of Jaundice in Adults |journal=Am Fam Physician |volume=95 |issue=3 |pages=164–168 |year=2017 |pmid=28145671 |doi= |url=}}</ref><ref name="pmid9287990">{{cite journal |vauthors=Leevy CB, Koneru B, Klein KM |title=Recurrent familial prolonged intrahepatic cholestasis of pregnancy associated with chronic liver disease |journal=Gastroenterology |volume=113 |issue=3 |pages=966–72 |year=1997 |pmid=9287990 |doi= |url=}}</ref><ref name="pmid18609700">{{cite journal |vauthors=Hov JR, Boberg KM, Karlsen TH |title=Autoantibodies in primary sclerosing cholangitis |journal=World J. Gastroenterol. |volume=14 |issue=24 |pages=3781–91 |year=2008 |pmid=18609700 |pmc=2721433 |doi= |url=}}</ref><ref name="pmid3115390">{{cite journal |vauthors=Bond LR, Hatty SR, Horn ME, Dick M, Meire HB, Bellingham AJ |title=Gall stones in sickle cell disease in the United Kingdom |journal=Br Med J (Clin Res Ed) |volume=295 |issue=6592 |pages=234–6 |year=1987 |pmid=3115390 |pmc=1247079 |doi= |url=}}</ref><ref name="pmid29226106">{{cite journal |vauthors=Malakouti M, Kataria A, Ali SK, Schenker S |title=Elevated Liver Enzymes in Asymptomatic Patients - What Should I Do? |journal=J Clin Transl Hepatol |volume=5 |issue=4 |pages=394–403 |year=2017 |pmid=29226106 |pmc=5719197 |doi=10.14218/JCTH.2017.00027 |url=}}</ref>
| | *Acute liver failure is a distinctive syndrome that is not confused with other conditions. The major differential diagnosis is in the cause of acute liver failure, whether viral ([[hepatitis A, B, C, D or]] [[E]]), [[autoimmune]], metabolic ([[Wilson disease]]), drug-induced or idiopathic. |
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| {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
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| ! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Classification of jaundice based on etiology
| |
| ! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
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| ! colspan="4" rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |History and clinical manifestations
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| ! colspan="8" align="center" style="background:#4479BA; color: #FFFFFF;" |Diagnosis
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| |-
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| ! colspan="6" align="center" style="background:#4479BA; color: #FFFFFF;" |Lab Findings
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| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other blood tests
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| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Other diagnostic
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| |-
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| ! rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Family history
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Fever
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |RUQ Pain
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Pruritis
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| ! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |AST
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| ! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALT
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| ! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |ALP
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| ! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Indirect
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| ! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |BLR Direct
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| ! colspan="1" rowspan="1" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral serology
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| |-
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| ! rowspan="34" align="center" style="background:#4479BA; color: #FFFFFF;" |Jaundice
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| ! colspan="1" rowspan="9" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hepatocellular Jaundice
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Infiltrative liver disorders: [[Hemochromatosis]], [[amyloidosis]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ferritin]] ↑ (hemochromatosis)
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
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| |-
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Wilson's disease]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑ Serum [[ceruloplasmin]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
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| |-
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis|Viral hepatitis]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Specific viral antibody for each type
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| |-
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Alcoholic hepatitis]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| |-
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Drug induced hepatitis
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| |-
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Autoimmune hepatitis]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-LKM antibody]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
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| |-
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| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cirrhosis]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low platate
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small liver on ultrasond
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| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-alcoholic fatty liver disease|Nonalcoholic steatohepatitis]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lipoprotein disorders|Dyslipidemia]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |liver biopsy
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| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Ischemic hepatopathy
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑/N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Circulatory system|Cardiovascular]] risk factors
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| |-
| |
| ! rowspan="10" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Cholestatic Jaundice
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Common bile duct stone
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated ducts on ultrasound
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT/[[Endoscopic retrograde cholangiopancreatography|ERCP]]
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| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis A]] (cholestatic type)
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |HAV- Ab
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abdominal ultrasound
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Epstein Barr virus|EBV]] / [[Cytomegalovirus infection|CMV]] hepatitis
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Positive serology
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Primary biliary cirrhosis]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |AMA positive
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Primary sclerosing cholangitis]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Autoantibodies (P-ANCA), [[hypergammaglobulinemia]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Magnetic resonance cholangiopancreatography|MRCP]],
| |
| Liver biopsy
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sickle-cell disease|Sickle cell disease]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +/-
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pancreatic cancer|Pancreatic carcinoma]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |CT scan for diagnosis
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[HIV AIDS|AIDS]] cholangiopathy
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |HIV Ab
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Ultrasound or [[Endoscopic retrograde cholangiopancreatography|ERCP]]
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Parasites induces cholestasis
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N/↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Serology
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Ultrasound or [[Endoscopic retrograde cholangiopancreatography|ERCP]]
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Intrahepatic cholestasis of pregnancy
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Diagnosed clinically
| |
| |-
| |
| ! rowspan="10" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Isolated Jaundice
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Crigler-Najjar syndrome|Crigler-Najjar]] type 2
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gilbert's syndrome|Gilbert]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rotor syndrome]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Dubin-Johnson syndrome]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Liver biopsy
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hereditary spherocytosis]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Osmotic fragility
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Glucose-6-phosphate dehydrogenase deficiency|G6PD deficiency]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Thalassemia]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Genetic testing
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Paroxysmal nocturnal hemoglobinuria]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Flocytometery
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Immune [[hemolysis]]
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | colspan="2" style="padding: 5px 5px; background: #F5F5F5;" align="center" |Autoantibodies
| |
| |-
| |
| | colspan="1" rowspan="1" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Hematoma
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -/+
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |N
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | -
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Anemia
| |
| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |Truma or surgery in history
| |
| |-
| |
| |}
| |
| |}
| |
| | |
|
| |
|
| ==Epidemiology and Demographics== | | ==Epidemiology and Demographics== |