Jaundice laboratory findings: Difference between revisions
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** Conjugated hyperbilirubinemia: | ** Conjugated hyperbilirubinemia: | ||
*** Serum conjugated bilirubin concentration >0.4 mg/dL (6.8 micromol/L). | *** Serum conjugated bilirubin concentration >0.4 mg/dL (6.8 micromol/L). | ||
*** Direct bilirubin >1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL (85 micromol/L), or more than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL(85 micromol/L). | *** Direct bilirubin >1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL (85 micromol/L), or more than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL(85 micromol/L).<ref name="pmid21250253">{{cite journal |vauthors=Walker HK, Hall WD, Hurst JW, Stillman AE |title= |journal= |volume= |issue= |pages= |year= |pmid=21250253 |doi= |url=}}</ref> | ||
** Unconjugated hyperbilirubinemia: | ** Unconjugated hyperbilirubinemia: | ||
*** Conjugated bilirubin is <1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL, or less than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL (85 micromol/L). | *** Conjugated bilirubin is <1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL, or less than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL (85 micromol/L).<ref name="pmid21250253">{{cite journal |vauthors=Walker HK, Hall WD, Hurst JW, Stillman AE |title= |journal= |volume= |issue= |pages= |year= |pmid=21250253 |doi= |url=}}</ref> | ||
** | ** | ||
* [[Aspartate transaminase]](AST) (or) SGOT | * [[Aspartate transaminase]](AST) (or) SGOT | ||
Revision as of 19:38, 5 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
- Laboratory findings consistent with the diagnosis of jaundice include:
- An elevated concentration of serum total bilirubin. the upper limit of normal is >1 mg/dL or >1.3 mg/d in some laboratories. Jaundice usually becomes clinically apparent when the serum total bilirubin concentration is greater than 2 to 3 mg/dL , but threshold for clinically apparent jaundice may vary among patients.[1]
- Hyperbilirubinemia can be further categorized as conjugated or unconjugated:
- Conjugated hyperbilirubinemia:
- Serum conjugated bilirubin concentration >0.4 mg/dL (6.8 micromol/L).
- Direct bilirubin >1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL (85 micromol/L), or more than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL(85 micromol/L).[1]
- Unconjugated hyperbilirubinemia:
- Conjugated bilirubin is <1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL, or less than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL (85 micromol/L).[1]
- Conjugated hyperbilirubinemia:
- Aspartate transaminase(AST) (or) SGOT
- Alanine transaminase(ALT) (or) SGPT
- Albumin
- Alkaline phosphatase
- HIV serologies
- Hepatitis serologies
- Antinuclear antibody (ANA)
- Antimitochondrial antibodies
- Haptoglobin
- Reticulocyte count
- Leukocytosis
- Lactic dehydrogenase (LDH)
Inalcoholic hepatitis the aspartate aminotransferase:alanine aminotransferase ratio is > 2 (AST:ALT)