Sjögren's syndrome pathophysiology: Difference between revisions
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The [[pathogenesis]] of [[Sjögren's syndrome]] can be linked to both genetic and nongenetic components <ref name="pmid23846338">{{cite journal| author=Mavragani CP, Nezos A, Moutsopoulos HM| title=New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. | journal=Curr Opin Rheumatol | year= 2013 | volume= 25 | issue= 5 | pages= 623-9 | pmid=23846338 | doi=10.1097/BOR.0b013e328363eaa5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23846338 }} </ref>. | The [[pathogenesis]] of [[Sjögren's syndrome]] can be linked to both genetic and nongenetic components <ref name="pmid23846338">{{cite journal| author=Mavragani CP, Nezos A, Moutsopoulos HM| title=New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. | journal=Curr Opin Rheumatol | year= 2013 | volume= 25 | issue= 5 | pages= 623-9 | pmid=23846338 | doi=10.1097/BOR.0b013e328363eaa5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23846338 }} </ref>. | ||
* '''Genetic components:''' | * '''Genetic components:''' | ||
Multiple genes are found to be associated with ُ[[Sjögren's syndrome]]. Evidence suggests genes that encode [[Major histocompatibility complex|Major Histocompatibility Complex]] (MHC), particularly [[Human leukocyte antigen|HLA]] genes, play an important role in the disease, although ethnicity seems to affect these roles <ref name="pmid24097067">{{cite journal| author=Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM et al.| title=Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. | journal=Nat Genet | year= 2013 | volume= 45 | issue= 11 | pages= 1284-92 | pmid=24097067 | doi=10.1038/ng.2792 | pmc=3867192 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24097067 }}</ref>. Among non-HLA genes, | |||
* '''Environmental components:''' | * '''Environmental components:''' | ||
** Several studies have indicated an association between Sjögren's syndrome and some viral infections. | ** Several studies have indicated an association between Sjögren's syndrome and some viral infections. EBV, HIV, | ||
* '''Immune-mediated components:''' | * '''Immune-mediated components:''' | ||
Revision as of 17:25, 29 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farbod Zahedi Tajrishi, M.D.
Overview
ُSjögren's syndrome is a chronic auto-immune disorder that can affect several organ systems. Both genetic and immune factors contribute to the pathogenesis of the disease. In the most common presentation of the disease, lymphocytes infiltrate the lacrimal and salivary glands and impair their function, hence causing the main characteristic symptoms- dry mouth (keratoconjunctivitis sicca) and eyes (xerostomia). CD4+ T-cells are predominant in mild and moderate salivary gland infiltrations, while B cells play the major role in severe lesions [1].
Pathophysiology
The pathogenesis of Sjögren's syndrome can be linked to both genetic and nongenetic components [2].
- Genetic components:
Multiple genes are found to be associated with ُSjögren's syndrome. Evidence suggests genes that encode Major Histocompatibility Complex (MHC), particularly HLA genes, play an important role in the disease, although ethnicity seems to affect these roles [3]. Among non-HLA genes,
- Environmental components:
- Several studies have indicated an association between Sjögren's syndrome and some viral infections. EBV, HIV,
- Immune-mediated components:
References
- ↑ Christodoulou MI, Kapsogeorgou EK, Moutsopoulos HM (2010). "Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome". J Autoimmun. 34 (4): 400–7. doi:10.1016/j.jaut.2009.10.004. PMID 19889514.
- ↑ Mavragani CP, Nezos A, Moutsopoulos HM (2013). "New advances in the classification, pathogenesis and treatment of Sjogren's syndrome". Curr Opin Rheumatol. 25 (5): 623–9. doi:10.1097/BOR.0b013e328363eaa5. PMID 23846338.
- ↑ Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM; et al. (2013). "Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome". Nat Genet. 45 (11): 1284–92. doi:10.1038/ng.2792. PMC 3867192. PMID 24097067.