Sjögren's syndrome history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]


The most common symptoms of Sjögren's syndrome include ocular and oral symptoms. Patients with Sjögren's syndrome may have a positive history of rheumatoid arthritis (RA), systemic lupus erythematous (SLE) and non-Hodgkin B-cell lymphoma.

History and Symptoms

  • The most common symptoms of Sjögren's syndrome include ocular and oral symptoms.


Patients with Sjögren's syndrome may have positive past and family history of:

Common Symptoms

Common symptoms of Sjögren's syndrome include:[1][2][3][4][5][6][7][8][9][10]


  1. Kittridge A, Routhouska SB, Korman NJ (2011). "Dermatologic manifestations of Sjögren syndrome". J Cutan Med Surg. 15 (1): 8–14. doi:10.2310/7750.2010.09033. PMID 21291650.
  2. Roguedas AM, Misery L, Sassolas B, Le Masson G, Pennec YL, Youinou P (2004). "Cutaneous manifestations of primary Sjögren's syndrome are underestimated". Clin. Exp. Rheumatol. 22 (5): 632–6. PMID 15485020.
  3. Baimpa E, Dahabreh IJ, Voulgarelis M, Moutsopoulos HM (September 2009). "Hematologic manifestations and predictors of lymphoma development in primary Sjögren syndrome: clinical and pathophysiologic aspects". Medicine (Baltimore). 88 (5): 284–93. doi:10.1097/MD.0b013e3181b76ab5. PMID 19745687.
  4. Amezcua-Guerra LM, Hofmann F, Vargas A, Rodriguez-Henriquez P, Solano C, Hernández-Díaz C, Castillo-Martinez D, Ventura-Ríos L, Gutiérrez M, Pineda C (2013). "Joint involvement in primary Sjögren's syndrome: an ultrasound "target area approach to arthritis"". Biomed Res Int. 2013: 640265. doi:10.1155/2013/640265. PMC 3722787. PMID 23936829.
  5. Kanellopoulos P, Baltoyiannis C, Tzioufas AG (April 2002). "Primary Sjögren's syndrome associated with inclusion body myositis". Rheumatology (Oxford). 41 (4): 440–4. PMID 11961175.
  6. Pérez B, Kraus A, López G, Cifuentes M, Alarcón-Segovia D (November 1995). "Autoimmune thyroid disease in primary Sjögren's syndrome". Am. J. Med. 99 (5): 480–4. PMID 7485204.
  7. Ramirez-Mata M, Pena Ancira FF, Alarcon-Segovia D (March 1976). "Abnormal esophageal motility in primary Sjögren's syndrome". J. Rheumatol. 3 (1): 63–9. PMID 1271390.
  8. Lehrer S, Bogursky E, Yemini M, Kase NG, Birkenfeld A (March 1994). "Gynecologic manifestations of Sjögren's syndrome". Am. J. Obstet. Gynecol. 170 (3): 835–7. PMID 8141212.
  9. Binder A, Snaith ML, Isenberg D (August 1988). "Sjögren's syndrome: a study of its neurological complications". Br. J. Rheumatol. 27 (4): 275–80. PMID 3261608.
  10. Ramos-Casals M, Font J, Garcia-Carrasco M, Brito MP, Rosas J, Calvo-Alen J, Pallares L, Cervera R, Ingelmo M (July 2002). "Primary Sjögren syndrome: hematologic patterns of disease expression". Medicine (Baltimore). 81 (4): 281–92. PMID 12169883.